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Protein

Somatotropin

Gene

GH

Organism
Rhinella marina (Cane toad) (Bufo marinus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth hormone plays an important role in growth control.

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Somatotropin
Alternative name(s):
Growth hormone
Gene namesi
Name:GH
OrganismiRhinella marina (Cane toad) (Bufo marinus)
Taxonomic identifieri8386 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeRhinella

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000003300726 – 213SomatotropinAdd BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 186By similarity
Disulfide bondi203 ↔ 211By similarity

Keywords - PTMi

Disulfide bond

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO73849
SMRiO73849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG011318

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR034975 Somatotropin
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PTHR11417:SF2 PTHR11417:SF2, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGLCSSLG LLLIMCLQSP PGFSAFPQIP LASLLNNAVI RAQYIRQVVA
60 70 80 90 100
DTYRDYEQTF IREDKRYSNK NSYAMFCYSE TIPAPTDKDN THQKSDIDLL
110 120 130 140 150
RFSLTLIQSW MTPVQSLNKL FTNQVFGNAV YEKLRDLEEG LYALMRELDD
160 170 180 190 200
GNARNYGLLT FTYDKFDPHP DSDDDGRIKN YGLLSCFKKD MHKVETYLKV
210
MKCRRFVESN CMV
Length:213
Mass (Da):24,556
Last modified:August 1, 1998 - v1
Checksum:iCB24A0F31BB0DEFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF062746 mRNA Translation: AAC16497.1

Similar proteinsi

Entry informationi

Entry nameiSOMA_RHIMB
AccessioniPrimary (citable) accession number: O73849
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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