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Protein

Guanine nucleotide-binding protein subunit alpha-14

Gene

gna14

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Mediates responses to trypsin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481MagnesiumBy similarity
Metal bindingi181 – 1811MagnesiumBy similarity
Binding sitei326 – 3261GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488GTPBy similarity
Nucleotide bindingi175 – 1817GTPBy similarity
Nucleotide bindingi200 – 2045GTPBy similarity
Nucleotide bindingi269 – 2724GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-14
Short name:
G alpha-14
Short name:
G-protein subunit alpha-14
Gene namesi
Name:gna14
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254627. gna14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Guanine nucleotide-binding protein subunit alpha-14PRO_0000203754Add
BLAST

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Structurei

3D structure databases

ProteinModelPortaliO73819.
SMRiO73819. Positions 31-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

HOVERGENiHBG063184.
KOiK04636.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

O73819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGCCLSAEE KESQRINAEI EKQLRRDKRD ARRELKLLLL GTGESGKSTF
60 70 80 90 100
IKQMRIIHGS GYTDEDRKGF TKLVYQNIFT SMQSMIRAMD TLRIQYTSEQ
110 120 130 140 150
NMENALVIRE VEVDKVSSLE RKHVEAIKKL WEDEGIQECY DRRREYQLSD
160 170 180 190 200
STKYYLSDID RISNPGFIPT QQDVLRVRVP TTGIIEYPFD LENIIFRMVD
210 220 230 240 250
VGGQRSERRK WIHCFENVTS IIFLVALSEY DQVLAECDNE NRMEESKALF
260 270 280 290 300
KTIITYPWFQ NSSVILFLNK KDLLQEKIMY SHLIDYFPEF TGPKQDSQAA
310 320 330 340 350
RDFILKLYQD QNPDKEKVIY SHFTCATDTE NIRFVFAAVK DTILQLNLRE

FNLV
Length:354
Mass (Da):41,595
Last modified:August 1, 1998 - v1
Checksum:iC7105026B037600E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059182 mRNA. Translation: AAC41382.1.
RefSeqiNP_001083750.2. NM_001090281.2.
UniGeneiXl.14093.

Genome annotation databases

GeneIDi399096.
KEGGixla:399096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059182 mRNA. Translation: AAC41382.1.
RefSeqiNP_001083750.2. NM_001090281.2.
UniGeneiXl.14093.

3D structure databases

ProteinModelPortaliO73819.
SMRiO73819. Positions 31-353.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399096.
KEGGixla:399096.

Organism-specific databases

CTDi399096.
XenbaseiXB-GENE-6254627. gna14.

Phylogenomic databases

HOVERGENiHBG063184.
KOiK04636.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Galpha14 and Galphaq mediate the response to trypsin in Xenopus oocytes."
    Shapira H., Amit I., Revach M., Oron Y., Battey J.F.
    J. Biol. Chem. 273:19431-19436(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGNA14_XENLA
AccessioniPrimary (citable) accession number: O73819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: October 14, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.