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O73817 (PSB3_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-3

EC=3.4.25.1
Alternative name(s):
Proteasome chain 13
Proteasome component C10-II
Proteasome theta chain
Gene names
Name:psmb3
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm. Nucleus.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Proteasome subunit beta type-3
PRO_0000148060

Sequences

Sequence LengthMass (Da)Tools
O73817 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: E0177236217DD0D3

FASTA20523,021
        10         20         30         40         50         60 
MSIMSYNGGA VMAMKGKQCV AIAADRRFGV QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV 

        70         80         90        100        110        120 
QTVSQRLKFR LNLYELKEGR QIKPKTFMSM VSNLLYERRF GPYYIEPVIA GLDPKTFEPF 

       130        140        150        160        170        180 
ICSLDLIGCP MVTEDFVVSG TCSEQMYGMC ESLWEPDMEP EDLFETISQA MLNAVDRDAV 

       190        200 
SGMGVVVQVI EKDKITTRTL KARMD 

« Hide

References

[1]"Isolation of a rainbow trout (Oncorhynchus mykiss) proteasome cDNA."
Martin S.A.M.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF058707 mRNA. Translation: AAC14141.1.
RefSeqNP_001117722.1. NM_001124250.1.
UniGeneOmy.11891.

3D structure databases

ProteinModelPortalO73817.
SMRO73817. Positions 2-205.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.983.

Proteomic databases

PRIDEO73817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100135869.

Phylogenomic databases

HOVERGENHBG004446.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB3_ONCMY
AccessionPrimary (citable) accession number: O73817
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries