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Protein

D(2) dopamine receptor

Gene

DRD2

Organism
Meleagris gallopavo (Common turkey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei111 – 1111AgonistBy similarity

GO - Molecular functioni

  • dopamine binding Source: AgBase
  • dopamine neurotransmitter receptor activity Source: InterPro
  • receptor activity Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
D(2) dopamine receptor
Alternative name(s):
Dopamine D2 receptor
Gene namesi
Name:DRD2
OrganismiMeleagris gallopavo (Common turkey)
Taxonomic identifieri9103 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaeMeleagridinaeMeleagris
Proteomesi
  • UP000001645 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularBy similarityAdd
BLAST
Transmembranei35 – 5723Helical; Name=1By similarityAdd
BLAST
Topological domaini58 – 6710CytoplasmicBy similarity
Transmembranei68 – 9023Helical; Name=2By similarityAdd
BLAST
Topological domaini91 – 10515ExtracellularBy similarityAdd
BLAST
Transmembranei106 – 12722Helical; Name=3By similarityAdd
BLAST
Topological domaini128 – 14821CytoplasmicBy similarityAdd
BLAST
Transmembranei149 – 16921Helical; Name=4By similarityAdd
BLAST
Topological domaini170 – 18516ExtracellularBy similarityAdd
BLAST
Transmembranei186 – 21025Helical; Name=5By similarityAdd
BLAST
Topological domaini211 – 366156CytoplasmicBy similarityAdd
BLAST
Transmembranei367 – 38822Helical; Name=6By similarityAdd
BLAST
Topological domaini389 – 40214ExtracellularBy similarityAdd
BLAST
Transmembranei403 – 42422Helical; Name=7By similarityAdd
BLAST
Topological domaini425 – 43612CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436D(2) dopamine receptorPRO_0000069391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Disulfide bondi104 ↔ 179PROSITE-ProRule annotation
Disulfide bondi392 ↔ 394PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000004037.

Structurei

3D structure databases

ProteinModelPortaliO73810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni187 – 1948Agonist bindingBy similarity
Regioni379 – 3879Agonist bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiO73810.
KOiK04145.

Family and domain databases

InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73810-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLNLSWYN TGDRNWSEPV NESSADQKPQ YNYYAVLLTL LIFVIVFGNV
60 70 80 90 100
LVCMAVSREK ALQTTTNYLI VSLAVADLLV ATLVMPWVVY LEVVGEWRFS
110 120 130 140 150
RIHCDIFVTL DVMMCTASIL NLCAISIDRY TAAAMPMLYN TRYSSKRRVT
160 170 180 190 200
VMIACVWVLS FAISSPILFG LNKADERECI IANPAFVVYS SVVSFYVPFI
210 220 230 240 250
VTLLVYVQIY MVLRRRRKRH TKRSSHGLDS DTHAPLKDKC THPENVKLGT
260 270 280 290 300
VIVKSNGSFQ VNKRKCEAES HIKMEMEMMS STSPPERTIV KAAAPSNHQL
310 320 330 340 350
VVPVASSRST LDSPGKVEKN GHAKENLHTA KVFEIQSMPN GKTRSTLLKA
360 370 380 390 400
MNRRKLSQQK EKKATQMLAI VLGVFIICWL PFFITHILNM HCDCNIPPAM
410 420 430
YSAFTWLGYV NSAVNPIIYT TFNIEFRKAF MKILHC
Length:436
Mass (Da):49,389
Last modified:August 1, 1998 - v1
Checksum:i5FB13F684532C53B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056201 mRNA. Translation: AAD03818.1.
RefSeqiNP_001290091.1. NM_001303162.1.
UniGeneiMga.4445.

Genome annotation databases

GeneIDi100303660.
KEGGimgp:100303660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056201 mRNA. Translation: AAD03818.1.
RefSeqiNP_001290091.1. NM_001303162.1.
UniGeneiMga.4445.

3D structure databases

ProteinModelPortaliO73810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9103.ENSMGAP00000004037.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100303660.
KEGGimgp:100303660.

Organism-specific databases

CTDi1813.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOVERGENiHBG106962.
InParanoidiO73810.
KOiK04145.

Family and domain databases

InterProiIPR001922. Dopamine_D2_rcpt.
IPR000929. Dopamine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00567. DOPAMINED2R.
PR00242. DOPAMINER.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRD2_MELGA
AccessioniPrimary (citable) accession number: O73810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.