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Protein

Snake venom serine protease salmobin

Gene
N/A
Organism
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Snake venom serine protease that may act in the hemostasis system of the prey.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Charge relay systemBy similarity1
Active sitei112Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hemostasis impairing toxin, Hydrolase, Protease, Serine protease, Toxin

Protein family/group databases

MEROPSiS01.338.

Names & Taxonomyi

Protein namesi
Recommended name:
Snake venom serine protease salmobin (EC:3.4.21.-)
Short name:
SVSP
OrganismiGloydius halys (Chinese water mocassin) (Agkistrodon halys)
Taxonomic identifieri8714 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeGloydius

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000029619719 – 24By similarity6
ChainiPRO_000029619825 – 260Snake venom serine protease salmobinAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 165PROSITE-ProRule annotation
Disulfide bondi52 ↔ 68PROSITE-ProRule annotation
Disulfide bondi102 ↔ 258PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 212PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi176 ↔ 191PROSITE-ProRule annotation
Disulfide bondi202 ↔ 227PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO73800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 251Peptidase S1PROSITE-ProRule annotationAdd BLAST227

Sequence similaritiesi

Belongs to the peptidase S1 family. Snake venom subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIKVLANH LILQLSYAQK SSELVIGGDE CNINEHRFLV ALYHSRSRTF
60 70 80 90 100
LCGGTLINQE WVLTAAHCDR FLMYIRLGMH NKNVKFDDEQ RRFPKEKYFF
110 120 130 140 150
ACSNNFTKWD KDIMLIRLNR PVNNSEHIAP LSLPSNPPSV GSVCRVMGWG
160 170 180 190 200
TITSPNETLP DVPHCANINL LHYSVCQAAY PKLPVTRRLL CAGILEGGID
210 220 230 240 250
SCHRDSGGPL ICNGQFQGIV SWGRYPCAQP RVPGIYIKVF DYTDWIQSII
260
AGNTAVNCPP
Length:260
Mass (Da):29,219
Last modified:August 1, 1998 - v1
Checksum:iE185EAA1BC5FAC10
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 10KVLANH → RVIANL in AAC61838 (Ref. 2) Curated6
Sequence conflicti161D → V in AAC61838 (Ref. 2) Curated1
Sequence conflicti257N → T in AAC61838 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056033 mRNA. Translation: AAC13280.1.
AF015727 mRNA. Translation: AAC61838.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056033 mRNA. Translation: AAC13280.1.
AF015727 mRNA. Translation: AAC61838.1.

3D structure databases

ProteinModelPortaliO73800.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSPSN_GLOHA
AccessioniPrimary (citable) accession number: O73800
Secondary accession number(s): O93502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.