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Protein

Snake venom serine protease salmobin

Gene
N/A
Organism
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Snake venom serine protease that may act in the hemostasis system of the prey.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671Charge relay systemBy similarity
Active sitei112 – 1121Charge relay systemBy similarity
Active sitei206 – 2061Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hemostasis impairing toxin, Hydrolase, Protease, Serine protease, Toxin

Protein family/group databases

MEROPSiS01.338.

Names & Taxonomyi

Protein namesi
Recommended name:
Snake venom serine protease salmobin (EC:3.4.21.-)
Short name:
SVSP
OrganismiGloydius halys (Chinese water mocassin) (Agkistrodon halys)
Taxonomic identifieri8714 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeGloydius

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 246By similarityPRO_0000296197
Chaini25 – 260236Snake venom serine protease salmobinPRO_0000296198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 165PROSITE-ProRule annotation
Disulfide bondi52 ↔ 68PROSITE-ProRule annotation
Disulfide bondi102 ↔ 258PROSITE-ProRule annotation
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 212PROSITE-ProRule annotation
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi176 ↔ 191PROSITE-ProRule annotation
Disulfide bondi202 ↔ 227PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO73800.
SMRiO73800. Positions 25-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 251227Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Snake venom subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLIKVLANH LILQLSYAQK SSELVIGGDE CNINEHRFLV ALYHSRSRTF
60 70 80 90 100
LCGGTLINQE WVLTAAHCDR FLMYIRLGMH NKNVKFDDEQ RRFPKEKYFF
110 120 130 140 150
ACSNNFTKWD KDIMLIRLNR PVNNSEHIAP LSLPSNPPSV GSVCRVMGWG
160 170 180 190 200
TITSPNETLP DVPHCANINL LHYSVCQAAY PKLPVTRRLL CAGILEGGID
210 220 230 240 250
SCHRDSGGPL ICNGQFQGIV SWGRYPCAQP RVPGIYIKVF DYTDWIQSII
260
AGNTAVNCPP
Length:260
Mass (Da):29,219
Last modified:August 1, 1998 - v1
Checksum:iE185EAA1BC5FAC10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 106KVLANH → RVIANL in AAC61838 (Ref. 2) Curated
Sequence conflicti161 – 1611D → V in AAC61838 (Ref. 2) Curated
Sequence conflicti257 – 2571N → T in AAC61838 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056033 mRNA. Translation: AAC13280.1.
AF015727 mRNA. Translation: AAC61838.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056033 mRNA. Translation: AAC13280.1.
AF015727 mRNA. Translation: AAC61838.1.

3D structure databases

ProteinModelPortaliO73800.
SMRiO73800. Positions 25-260.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS01.338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cell surface display of salmobin, a thrombin-like enzyme from Agkistrodon halys venom on Escherichia coli using ice nucleation protein."
    Jeong H., Yoo S., Kim E.
    Enzyme Microb. Technol. 28:155-160(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. Chung K.H., Koh Y.S., Yun Y.D., Kim D.-S.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.

Entry informationi

Entry nameiVSPSN_GLOHA
AccessioniPrimary (citable) accession number: O73800
Secondary accession number(s): O93502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.