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O73792 (TIE1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor Tie-1

EC=2.7.10.1
Gene names
Name:tie1
Synonyms:tie-1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length184 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Expressed in most populations of endothelial cells in 24 hours embryos, including the endocardium. Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processAngiogenesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane receptor protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 184›184Tyrosine-protein kinase receptor Tie-1
PRO_0000088172

Regions

Domain‹1 – 164›164Protein kinase

Sites

Active site251Proton acceptor By similarity

Amino acid modifications

Modified residue531Phosphotyrosine; by autocatalysis By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O73792 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 38F6A35FFC1DB7F8

FASTA18421,190
        10         20         30         40         50         60 
QLLQFAADVA TGMHYLSDKQ FIHRDLAARN VLVGDNLVAK IADFGLSRGE EVYVKKTMGR 

        70         80         90        100        110        120 
LPVRWMAIES LNYSVYTTKS DVWSFGVLLW EIVSLGGTPY CGMTCAELYE KLPQGYRMEQ 

       130        140        150        160        170        180 
PRNCDDEVYE LMRQCWRDRP YERPPFSQIS VQLNRMQEAR KAYVNMALFE NFTYAGIDAT 


AEEA 

« Hide

References

[1]"Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases."
Lyons M.S., Bell B., Stainier D., Peters K.G.
Dev. Dyn. 212:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053633 mRNA. Translation: AAC09332.1.
UniGeneDr.75821.

3D structure databases

ProteinModelPortalO73792.
SMRO73792. Positions 1-182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000016803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ZFINZDB-GENE-990415-55. tie1.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000049232.
HOVERGENHBG008761.
PhylomeDBO73792.

Gene expression databases

BgeeO73792.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO73792.

Entry information

Entry nameTIE1_DANRE
AccessionPrimary (citable) accession number: O73792
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: August 1, 1998
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families