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Protein

Transcription factor COE3

Gene

coe3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts transcriptional activator.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE3
Short name:
xCOE3
Alternative name(s):
Olf-1/EBF-like 2
Short name:
OE-2
Short name:
xEBF-3
Short name:
xOE-2
Gene namesi
Name:coe3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-962547. ebf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 598598Transcription factor COE3PRO_0000107834Add
BLAST

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei163 – 1631Interaction with DNABy similarity
Sitei172 – 1721Interaction with DNABy similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini264 – 34784IPT/TIGAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 664Interaction with DNABy similarity
Regioni197 – 2048Interaction with DNABy similarity
Regioni236 – 2394Interaction with DNABy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi465 – 55692Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the COE family.Curated
Contains 1 IPT/TIG domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOVERGENiHBG005108.
KOiK09103.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGIQENIPR GGTTMKEEPL GGGMNPVRSW MHTAGVVDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLAMYDRQGQ PVEIERTTFV DFVEKDKEPN
110 120 130 140 150
SEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAII YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTAPSYLEN VATPCIKAIS PSEGWTTGGA TVIIIGDNFF DGLQVVFGTM
310 320 330 340 350
LVWSELITPH AIRVQTPPRH IPGVVEVTLS YKSKQFCKGA PGRFVYTALN
360 370 380 390 400
EPTIDYGFQR LQKVIPRHPG DPERLPKEVL LKRAADLVEA LYGMPHNNQE
410 420 430 440 450
IILKRAADIA EALYSVPRNH NQIPSLANTP SHSGMMGVNS FSSQLAVNVS
460 470 480 490 500
ETSQANDQVG YSRNTSSVSP RGYVPSSTPQ QSNYNTVSNS MNGYGNAGMP
510 520 530 540 550
NLGVPGSPGF LNGSSANSPY GIVPSSPTMA ASSVTLPSNC SSTHGIFSFS
560 570 580 590
PANVISAVKQ KSAFAPVVRP QASPPPSCTS ANGNGLQDMY FSPTFSKS
Length:598
Mass (Da):65,344
Last modified:May 4, 2001 - v2
Checksum:iAC61383E4CD58B0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040994 mRNA. Translation: AAC15659.3.
RefSeqiNP_001083801.1. NM_001090332.1.
UniGeneiXl.632.

Genome annotation databases

GeneIDi399125.
KEGGixla:399125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040994 mRNA. Translation: AAC15659.3.
RefSeqiNP_001083801.1. NM_001090332.1.
UniGeneiXl.632.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399125.
KEGGixla:399125.

Organism-specific databases

CTDi253738.
XenbaseiXB-GENE-962547. ebf3.

Phylogenomic databases

HOVERGENiHBG005108.
KOiK09103.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOE3_XENLA
AccessioniPrimary (citable) accession number: O73742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 4, 2001
Last modified: May 11, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.