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Protein
Submitted name:

Endothelin receptor type A

Gene

EDNRA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Endothelin receptor type AImported
Submitted name:
Endothelin type A receptorImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EDNRAImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei75 – 100HelicalSequence analysisAdd BLAST26
Transmembranei112 – 137HelicalSequence analysisAdd BLAST26
Transmembranei187 – 212HelicalSequence analysisAdd BLAST26
Transmembranei251 – 277HelicalSequence analysisAdd BLAST27
Transmembranei298 – 316HelicalSequence analysisAdd BLAST19
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500877864021 – 421Sequence analysisAdd BLAST401

Expressioni

Gene expression databases

BgeeiENSGALG00000010013.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016244.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 363G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST273

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALYLRVSS LLLLLGFVLC DSSDKYATNW SDVGIYLPTS SGIESSLLPT
60 70 80 90 100
TRRPPVSNQT VKCSQQTKIA ETFKYINTVV SCAIFIVGMV GNATLLRIIY
110 120 130 140 150
QNKCMRNGPN ALIASLALGD LIYIVIDIPI IVYKLLAQKW PFGDSEFGQF
160 170 180 190 200
LCKFLPFIQK ASVGITVLNL CALSVDRYRA VASWSRVQGI GIPMITAIEI
210 220 230 240 250
FSIWLLSFIL AIPEAIGFAV VPFRYKDESY VTCMLNPTNK FMLFYKDAKD
260 270 280 290 300
WWLFGFYFCM PLACTAIFYT LMTCEMLNRR NSNLRIALSE HLKQRREVAK
310 320 330 340 350
TVFCLVVIFA LCWFPLHLSR ILKKMVYNER DPGRCELLSF LLPLDYISIN
360 370 380 390 400
LATMNSCINP IALYFVSKKF KNCFQSCLCC CCSQSKSLAT SVPMNGTSIQ
410 420
WKNQELNNHN TDRSSHKDSI N
Length:421
Mass (Da):47,713
Last modified:August 1, 1998 - v1
Checksum:i33A2C97A6DCD02DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000021 Genomic DNA. No translation available.
AF040634 mRNA. Translation: AAC77793.1.
AF472618 mRNA. Translation: AAM74025.1.
RefSeqiNP_989450.1. NM_204119.1.
UniGeneiGga.137.

Genome annotation databases

EnsembliENSGALT00000016263; ENSGALP00000016244; ENSGALG00000010013.
GeneIDi373908.
KEGGigga:373908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000021 Genomic DNA. No translation available.
AF040634 mRNA. Translation: AAC77793.1.
AF472618 mRNA. Translation: AAM74025.1.
RefSeqiNP_989450.1. NM_204119.1.
UniGeneiGga.137.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016244.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016263; ENSGALP00000016244; ENSGALG00000010013.
GeneIDi373908.
KEGGigga:373908.

Organism-specific databases

CTDi1909.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSGALG00000010013.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO73739_CHICK
AccessioniPrimary (citable) accession number: O73739
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.