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Protein

Insulin

Gene

ins

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

GO - Biological processi

  • glucose metabolic process Source: UniProtKB-KW
  • negative regulation of feeding behavior Source: ZFIN
  • positive regulation of pancreatic A cell differentiation Source: ZFIN
  • response to glucose Source: ZFIN
  • response to nutrient levels Source: ZFIN
  • type B pancreatic cell differentiation Source: ZFIN

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

ReactomeiR-DRE-264876 Insulin processing
R-DRE-6807878 COPI-mediated anterograde transport
R-DRE-74713 IRS activation
R-DRE-74749 Signal attenuation
R-DRE-74751 Insulin receptor signalling cascade
R-DRE-74752 Signaling by Insulin receptor
R-DRE-77387 Insulin receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:ins
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-980526-110 ins

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000001576722 – 51Insulin B chainAdd BLAST30
PropeptideiPRO_000001576854 – 84C peptideAdd BLAST31
PeptideiPRO_000001576988 – 108Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 94Interchain (between B and A chains)By similarity
Disulfide bondi42 ↔ 107Interchain (between B and A chains)By similarity
Disulfide bondi93 ↔ 98By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO73727

Expressioni

Gene expression databases

BgeeiENSDARG00000035350
ExpressionAtlasiO73727 baseline

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051221

Structurei

3D structure databases

ProteinModelPortaliO73727
SMRiO73727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiO73727
KOiK04526
OMAiPQHLCGS
OrthoDBiEOG091G0H56
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWLQAGAL LVLLVVSSVS TNPGTPQHLC GSHLVDALYL VCGPTGFFYN
60 70 80 90 100
PKRDVEPLLG FLPPKSAQET EVADFAFKDH AELIRKRGIV EQCCHKPCSI

FELQNYCN
Length:108
Mass (Da):11,904
Last modified:August 1, 1998 - v1
Checksum:i31D03CCF37BD2C22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036326 mRNA Translation: AAC41261.1
BC095013 mRNA Translation: AAH95013.1
RefSeqiNP_571131.1, NM_131056.1
UniGeneiDr.75811

Genome annotation databases

EnsembliENSDART00000051222; ENSDARP00000051221; ENSDARG00000035350
GeneIDi30262
KEGGidre:30262

Similar proteinsi

Entry informationi

Entry nameiINS_DANRE
AccessioniPrimary (citable) accession number: O73727
Secondary accession number(s): Q504H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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