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Protein
Submitted name:

Homeobox protein PDX-1

Gene

pdx1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi137 – 196HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • determination of digestive tract left/right asymmetry Source: ZFIN
  • determination of liver left/right asymmetry Source: ZFIN
  • determination of pancreatic left/right asymmetry Source: ZFIN
  • endocrine pancreas development Source: ZFIN
  • glucose homeostasis Source: ZFIN
  • pancreas development Source: ZFIN

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein PDX-1Imported
Gene namesi
Name:pdx1Imported
Synonyms:ipf1Imported, pdx-1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-122. pdx1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO73726.

Structurei

3D structure databases

ProteinModelPortaliO73726.
SMRiO73726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 195HomeoboxInterPro annotationAdd BLAST61

Sequence similaritiesi

Belongs to the Antp homeobox family.UniRule annotationSAAS annotation

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000115484.
HOVERGENiHBG004525.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017995. Homeobox_antennapedia.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O73726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNREEHYYPP NHLYKDSCAF QRHPNEDYSQ NPPPCLYMRQ AHSVYASPLG
60 70 80 90 100
AQDQPNLTDI TSYNMSSRDD PAGPHLHLPQ TSQTSLQSLG GYGDSLDLCG
110 120 130 140 150
DRNRYHLPFP WMKSTKSHTH AWKGQWTGPY MVEAEENKRT RTAYTRAQLL
160 170 180 190 200
ELEKEFLFNK YISRPRRVEL ALTLSLTERH IKIWFQNRRM KWKKEEDKRR
210 220 230 240
ARGVDPEQDS SITSGDLKDE SCVGTATLAG PPSPLHPHAP SVQQDS
Length:246
Mass (Da):28,366
Last modified:August 1, 1998 - v1
Checksum:iA15DDB2F8C3882C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036325 mRNA. Translation: AAC41260.1.
UniGeneiDr.75810.

Similar proteinsi

Entry informationi

Entry nameiO73726_DANRE
AccessioniPrimary (citable) accession number: O73726
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)