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Protein
Submitted name:

Homeobox protein PDX-1

Gene

pdx1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • determination of digestive tract left/right asymmetry Source: ZFIN
  • determination of liver left/right asymmetry Source: ZFIN
  • determination of pancreatic left/right asymmetry Source: ZFIN
  • endocrine pancreas development Source: ZFIN
  • pancreas development Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein PDX-1Imported
Gene namesi
Name:pdx1Imported
Synonyms:ipf1Imported, pdx-1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-122. pdx1.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO73726.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017531.

Structurei

3D structure databases

ProteinModelPortaliO73726.
SMRiO73726. Positions 137-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 19561Homeobox DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.UniRule annotationSAAS annotation
Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000115484.
HOVERGENiHBG004525.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNREEHYYPP NHLYKDSCAF QRHPNEDYSQ NPPPCLYMRQ AHSVYASPLG
60 70 80 90 100
AQDQPNLTDI TSYNMSSRDD PAGPHLHLPQ TSQTSLQSLG GYGDSLDLCG
110 120 130 140 150
DRNRYHLPFP WMKSTKSHTH AWKGQWTGPY MVEAEENKRT RTAYTRAQLL
160 170 180 190 200
ELEKEFLFNK YISRPRRVEL ALTLSLTERH IKIWFQNRRM KWKKEEDKRR
210 220 230 240
ARGVDPEQDS SITSGDLKDE SCVGTATLAG PPSPLHPHAP SVQQDS
Length:246
Mass (Da):28,366
Last modified:August 1, 1998 - v1
Checksum:iA15DDB2F8C3882C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036325 mRNA. Translation: AAC41260.1.
UniGeneiDr.75810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036325 mRNA. Translation: AAC41260.1.
UniGeneiDr.75810.

3D structure databases

ProteinModelPortaliO73726.
SMRiO73726. Positions 137-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017531.

Proteomic databases

PaxDbiO73726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990415-122. pdx1.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000115484.
HOVERGENiHBG004525.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conservation of PDX-1 structure, function, and expression in zebrafish."
    Milewski W.M., Duguay S.J., Chan S.J., Steiner D.F.
    Endocrinology 139:1440-1449(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PancreasImported.

Entry informationi

Entry nameiO73726_DANRE
AccessioniPrimary (citable) accession number: O73726
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.