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Protein
Submitted name:

Homeobox protein Six6

Gene

six3b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi168 – 227HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • brain development Source: ZFIN
  • embryonic camera-type eye morphogenesis Source: ZFIN
  • eye development Source: ZFIN
  • optic nerve development Source: ZFIN
  • optic nerve morphogenesis Source: ZFIN
  • sensory epithelium regeneration Source: ZFIN

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImported

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein Six6Imported
Submitted name:
SIX homeobox 3bImported
Submitted name:
Sine oculis homeobox homolog 3bImported
Submitted name:
Six3Imported
Gene namesi
Name:six3bImported
Synonyms:six3Imported, six6Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-990415-128. six3b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000054879.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071625.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini166 – 226HomeoboxInterPro annotationAdd BLAST61

Keywords - Domaini

HomeoboxPROSITE-ProRule annotationImported

Phylogenomic databases

eggNOGiKOG0775. Eukaryota.
ENOG410XRPB. LUCA.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000261680.
HOVERGENiHBG003609.
OrthoDBiEOG091G083I.
TreeFamiTF315545.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR031701. SIX1_SD.
IPR032949. SIX3.
PANTHERiPTHR10390:SF31. PTHR10390:SF31. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF16878. SIX1_SD. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O73709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFRSPLELY PSHLFLPNFA DRPLLLAGSI PRARSPEDLP MFQLPTLNFS
60 70 80 90 100
AEQVASVCET LEETGDIERL GRFLWSLPVA PGACDAINKH ESIQRARAVV
110 120 130 140 150
AYHTGSFREL YHILETHKFT KDSHGKLQAM WLEAHYQEAE KLRGRPLGPV
160 170 180 190 200
DKYRVRKKFP LPRTIWDGEQ KTHCFKERTR GLLREWYLQD PYPNPSKKRE
210 220 230 240 250
LAQATGLTPT QVGNWFKNRR QRDRAAAAKN RLQHHGLGQS SLRSMSESGC
260 270 280 290
TPHSSAESPC AAASPTTSVS SMNERGDGGT ILSVTDSDSD FDV
Length:293
Mass (Da):33,012
Last modified:August 1, 1998 - v1
Checksum:i56EC18007B2C676D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932018 Genomic DNA. No translation available.
AF030281 mRNA. Translation: AAC27449.1.
BC059425 mRNA. Translation: AAH59425.1.
AB004881 mRNA. Translation: BAA31752.1.
RefSeqiNP_571438.1. NM_131363.1.
UniGeneiDr.75402.

Genome annotation databases

EnsembliENSDART00000077157; ENSDARP00000071625; ENSDARG00000054879.
GeneIDi30636.
KEGGidre:30636.

Similar proteinsi

Entry informationi

Entry nameiO73709_DANRE
AccessioniPrimary (citable) accession number: O73709
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported