ID   CAC1C_CHICK             Reviewed;         177 AA.
AC   O73707;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   24-JAN-2024, entry version 130.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha-1C;
DE   AltName: Full=CHCACHA1C;
DE   AltName: Full=Voltage-gated calcium channel subunit alpha Cav1.2;
DE   Flags: Fragment;
GN   Name=CACNA1C;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Basilar papilla;
RX   PubMed=9405708; DOI=10.1073/pnas.94.26.14883;
RA   Kollmar R., Montgomery L.G., Fak J., Henry L.J., Hudspeth A.J.;
RT   "Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels
RT   of hair cells in the chicken's cochlea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:14883-14888(1997).
CC   -!- FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium
CC       channel that gives rise to L-type calcium currents. Mediates influx of
CC       calcium ions into the cytoplasm, and thereby triggers calcium release
CC       from the sarcoplasm. Plays an important role in excitation-contraction
CC       coupling in the heart. Required for normal heart development and normal
CC       regulation of heart rhythm (By similarity). Required for normal
CC       contraction of smooth muscle cells in blood vessels and in the
CC       intestine. Essential for normal blood pressure regulation via its role
CC       in the contraction of arterial smooth muscle cells (By similarity).
CC       Long-lasting (L-type) calcium channels belong to the 'high-voltage
CC       activated' (HVA) group (By similarity). {ECO:0000250|UniProtKB:P15381,
CC       ECO:0000250|UniProtKB:Q01815, ECO:0000250|UniProtKB:Q13936}.
CC   -!- ACTIVITY REGULATION: Inhibited by dihydropyridines (DHP), such as
CC       isradipine. Channel activity is regulated by Ca(2+) and calmodulin.
CC       {ECO:0000250|UniProtKB:Q13936}.
CC   -!- SUBUNIT: Component of a calcium channel complex consisting of a pore-
CC       forming alpha subunit (CACNA1C) and ancillary beta, gamma and delta
CC       subunits. The channel complex contains alpha, beta, gamma and delta
CC       subunits in a 1:1:1:1 ratio, i.e. it contains only one of each type of
CC       subunit. CACNA1C channel activity is modulated by ancillary subunits,
CC       such as CACNB2, CACNB3, CACNA2D1 and CACNA2D4.
CC       {ECO:0000250|UniProtKB:Q13936}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P22002};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P22002}. Perikaryon
CC       {ECO:0000250|UniProtKB:P22002}. Postsynaptic density membrane
CC       {ECO:0000250|UniProtKB:P22002}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:P22002}. Cell membrane, sarcolemma, T-tubule
CC       {ECO:0000250|UniProtKB:Q01815}. Note=The interaction between RRAD and
CC       CACNB2 promotes the expression of CACNA1C at the cell membrane.
CC       {ECO:0000250|UniProtKB:P15381}.
CC   -!- DOMAIN: Each of the four internal repeats contains five hydrophobic
CC       transmembrane segments (S1, S2, S3, S5, S6) and one positively charged
CC       transmembrane segment (S4). S4 segments probably represent the voltage-
CC       sensor and are characterized by a series of positively charged amino
CC       acids at every third position.
CC   -!- DOMAIN: Binding of intracellular calcium through the EF-hand motif
CC       inhibits the opening of the channel. {ECO:0000250|UniProtKB:P15381}.
CC   -!- PTM: Phosphorylation by PKA activates the channel.
CC       {ECO:0000250|UniProtKB:P15381}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. CACNA1C subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF027610; AAC08311.1; -; mRNA.
DR   AlphaFoldDB; O73707; -.
DR   SMR; O73707; -.
DR   STRING; 9031.ENSGALP00000066917; -.
DR   GlyCosmos; O73707; 2 sites, No reported glycans.
DR   PaxDb; 9031-ENSGALP00000021230; -.
DR   VEuPathDB; HostDB:geneid_395891; -.
DR   eggNOG; KOG2301; Eukaryota.
DR   InParanoid; O73707; -.
DR   PhylomeDB; O73707; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:1990454; C:L-type voltage-gated calcium channel complex; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042383; C:sarcolemma; ISS:UniProtKB.
DR   GO; GO:0030315; C:T-tubule; ISS:UniProtKB.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:UniProtKB.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0061577; P:calcium ion transmembrane transport via high voltage-gated calcium channel; ISS:UniProtKB.
DR   GO; GO:0060402; P:calcium ion transport into cytosol; ISS:UniProtKB.
DR   GO; GO:0061337; P:cardiac conduction; ISS:UniProtKB.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; ISS:UniProtKB.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR   PANTHER; PTHR45628:SF10; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00167; CACHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Calcium channel; Calcium transport; Calmodulin-binding;
KW   Cell membrane; Cell projection; Disulfide bond; Glycoprotein; Ion channel;
KW   Ion transport; Membrane; Phosphoprotein; Postsynaptic cell membrane;
KW   Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           <1..>177
FT                   /note="Voltage-dependent L-type calcium channel subunit
FT                   alpha-1C"
FT                   /id="PRO_0000053932"
FT   TRANSMEM        27..45
FT                   /note="Helical; Name=S4 of repeat IV"
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   TRANSMEM        64..84
FT                   /note="Helical; Name=S5 of repeat IV"
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   INTRAMEM        107..125
FT                   /note="Pore-forming"
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   TRANSMEM        154..>177
FT                   /note="Helical; Name=S6 of repeat IV"
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   MOTIF           116..119
FT                   /note="Selectivity filter of repeat IV"
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   SITE            118
FT                   /note="Calcium ion selectivity and permeability"
FT                   /evidence="ECO:0000250|UniProtKB:P15381"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        141
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        133..149
FT                   /evidence="ECO:0000250|UniProtKB:P07293"
FT   NON_TER         1
FT   NON_TER         177
SQ   SEQUENCE   177 AA;  19957 MW;  84CB4656D78AAF23 CRC64;
     ALIVVGSIVD IAITEVNNAE ENSRISITFF RLFRVMRLVK LLSRGEGIRT LLWTFIKSFQ
     ALPYVALLIV MLFFIYAVIG MQVFGKIALN DTTEINRNNN FQTFPQAVLL LFRCATGEAW
     QEIMLACLPD KKCDPDSEPA NSTEADHSCG SSFAVFYFIS FYMLCAFLII DLFVAVI
//