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Protein

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

CACNA1C

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei118Calcium ion selectivity and permeabilityBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Alternative name(s):
CHCACHA1C
Voltage-gated calcium channel subunit alpha Cav1.2
Gene namesi
Name:CACNA1C
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Membrane By similarity; Multi-pass membrane protein By similarity
  • Cell membrane By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei‹1 – 13Helical; Name=S3 of repeat IVSequence analysisAdd BLAST›13
Topological domaini14 – 26ExtracellularSequence analysisAdd BLAST13
Transmembranei27 – 45Helical; Name=S4 of repeat IVSequence analysisAdd BLAST19
Topological domaini46 – 64CytoplasmicSequence analysisAdd BLAST19
Transmembranei65 – 84Helical; Name=S5 of repeat IVSequence analysisAdd BLAST20
Topological domaini85 – 153ExtracellularSequence analysisAdd BLAST69
Transmembranei154 – ›177Helical; Name=S6 of repeat IVSequence analysisAdd BLAST›24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000053932‹1 – ›177Voltage-dependent L-type calcium channel subunit alpha-1CAdd BLAST›177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation by PKA activates the channel.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO73707.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021218.

Structurei

3D structure databases

ProteinModelPortaliO73707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati‹1 – ›177IVAdd BLAST›177

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – ›177Dihydropyridine bindingBy similarityAdd BLAST›46
Regioni146 – ›177Phenylalkylamine bindingBy similarityAdd BLAST›32

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
InParanoidiO73707.
PhylomeDBiO73707.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.

Sequencei

Sequence statusi: Fragment.

O73707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALIVVGSIVD IAITEVNNAE ENSRISITFF RLFRVMRLVK LLSRGEGIRT
60 70 80 90 100
LLWTFIKSFQ ALPYVALLIV MLFFIYAVIG MQVFGKIALN DTTEINRNNN
110 120 130 140 150
FQTFPQAVLL LFRCATGEAW QEIMLACLPD KKCDPDSEPA NSTEADHSCG
160 170
SSFAVFYFIS FYMLCAFLII DLFVAVI
Length:177
Mass (Da):19,957
Last modified:August 1, 1998 - v1
Checksum:i84CB4656D78AAF23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1771

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027610 mRNA. Translation: AAC08311.1.
UniGeneiGga.525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027610 mRNA. Translation: AAC08311.1.
UniGeneiGga.525.

3D structure databases

ProteinModelPortaliO73707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021218.

Proteomic databases

PaxDbiO73707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
InParanoidiO73707.
PhylomeDBiO73707.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1C_CHICK
AccessioniPrimary (citable) accession number: O73707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.