Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O73707

- CAC1C_CHICK

UniProt

O73707 - CAC1C_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

CACNA1C

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1181Calcium ion selectivity and permeabilityBy similarity

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Alternative name(s):
CHCACHA1C
Voltage-gated calcium channel subunit alpha Cav1.2
Gene namesi
Name:CACNA1C
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›177›177Voltage-dependent L-type calcium channel subunit alpha-1CPRO_0000053932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylation by PKA activates the channel.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO73707.

Interactioni

Subunit structurei

Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021218.

Structurei

3D structure databases

ProteinModelPortaliO73707.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini14 – 2613ExtracellularSequence AnalysisAdd
BLAST
Topological domaini46 – 6419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini85 – 15369ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei‹1 – 13›13Helical; Name=S3 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei27 – 4519Helical; Name=S4 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei65 – 8420Helical; Name=S5 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei154 – ›177›24Helical; Name=S6 of repeat IVSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati‹1 – ›177›177IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – ›177›46Dihydropyridine bindingBy similarityAdd
BLAST
Regioni146 – ›177›32Phenylalkylamine bindingBy similarityAdd
BLAST

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231529.
InParanoidiO73707.
PhylomeDBiO73707.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.

Sequencei

Sequence statusi: Fragment.

O73707-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ALIVVGSIVD IAITEVNNAE ENSRISITFF RLFRVMRLVK LLSRGEGIRT
60 70 80 90 100
LLWTFIKSFQ ALPYVALLIV MLFFIYAVIG MQVFGKIALN DTTEINRNNN
110 120 130 140 150
FQTFPQAVLL LFRCATGEAW QEIMLACLPD KKCDPDSEPA NSTEADHSCG
160 170
SSFAVFYFIS FYMLCAFLII DLFVAVI
Length:177
Mass (Da):19,957
Last modified:August 1, 1998 - v1
Checksum:i84CB4656D78AAF23
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei177 – 1771

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027610 mRNA. Translation: AAC08311.1.
UniGeneiGga.525.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF027610 mRNA. Translation: AAC08311.1 .
UniGenei Gga.525.

3D structure databases

ProteinModelPortali O73707.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000021218.

Proteomic databases

PaxDbi O73707.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231529.
InParanoidi O73707.
PhylomeDBi O73707.

Family and domain databases

InterProi IPR005821. Ion_trans_dom.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
ProtoNeti Search...

Publicationsi

  1. "Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea."
    Kollmar R., Montgomery L.G., Fak J., Henry L.J., Hudspeth A.J.
    Proc. Natl. Acad. Sci. U.S.A. 94:14883-14888(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Basilar papilla.

Entry informationi

Entry nameiCAC1C_CHICK
AccessioniPrimary (citable) accession number: O73707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3