Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O73707

- CAC1C_CHICK

UniProt

O73707 - CAC1C_CHICK

Protein

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

CACNA1C

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei118 – 1181Calcium ion selectivity and permeabilityBy similarity

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: InterPro

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent L-type calcium channel subunit alpha-1C
    Alternative name(s):
    CHCACHA1C
    Voltage-gated calcium channel subunit alpha Cav1.2
    Gene namesi
    Name:CACNA1C
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›177›177Voltage-dependent L-type calcium channel subunit alpha-1CPRO_0000053932Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylation by PKA activates the channel.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO73707.

    Interactioni

    Subunit structurei

    Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000021218.

    Structurei

    3D structure databases

    ProteinModelPortaliO73707.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini14 – 2613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 6419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini85 – 15369ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei‹1 – 13›13Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei27 – 4519Helical; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8420Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei154 – ›177›24Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati‹1 – ›177›177IVAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – ›177›46Dihydropyridine bindingBy similarityAdd
    BLAST
    Regioni146 – ›177›32Phenylalkylamine bindingBy similarityAdd
    BLAST

    Domaini

    Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
    Binding of intracellular calcium through the EF-hand motif inhibits the opening of the channel.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231529.
    PhylomeDBiO73707.

    Family and domain databases

    InterProiIPR005821. Ion_trans_dom.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.

    Sequencei

    Sequence statusi: Fragment.

    O73707-1 [UniParc]FASTAAdd to Basket

    « Hide

    ALIVVGSIVD IAITEVNNAE ENSRISITFF RLFRVMRLVK LLSRGEGIRT    50
    LLWTFIKSFQ ALPYVALLIV MLFFIYAVIG MQVFGKIALN DTTEINRNNN 100
    FQTFPQAVLL LFRCATGEAW QEIMLACLPD KKCDPDSEPA NSTEADHSCG 150
    SSFAVFYFIS FYMLCAFLII DLFVAVI 177
    Length:177
    Mass (Da):19,957
    Last modified:August 1, 1998 - v1
    Checksum:i84CB4656D78AAF23
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei177 – 1771

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027610 mRNA. Translation: AAC08311.1.
    UniGeneiGga.525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF027610 mRNA. Translation: AAC08311.1 .
    UniGenei Gga.525.

    3D structure databases

    ProteinModelPortali O73707.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000021218.

    Proteomic databases

    PaxDbi O73707.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231529.
    PhylomeDBi O73707.

    Family and domain databases

    InterProi IPR005821. Ion_trans_dom.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Predominance of the alpha1D subunit in L-type voltage-gated Ca2+ channels of hair cells in the chicken's cochlea."
      Kollmar R., Montgomery L.G., Fak J., Henry L.J., Hudspeth A.J.
      Proc. Natl. Acad. Sci. U.S.A. 94:14883-14888(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.
      Tissue: Basilar papilla.

    Entry informationi

    Entry nameiCAC1C_CHICK
    AccessioniPrimary (citable) accession number: O73707
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3