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Protein

Zinc finger protein ZIC 1

Gene

zic1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border. Cooperates with pax3 in concert with wnt signaling to determine neural crest fate. Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri221 – 256C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri265 – 292C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri298 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri328 – 352C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri358 – 380C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral neural tube patterning Source: UniProtKB
  • neural crest cell differentiation Source: UniProtKB
  • neural crest cell fate commitment Source: UniProtKB
  • neural crest formation Source: UniProtKB
  • neural plate development Source: UniProtKB
  • neurogenesis Source: UniProtKB
  • positive regulation of protein import into nucleus Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation, Wnt signaling pathway
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 1
Short name:
XZic1
Short name:
XlZic1
Alternative name(s):
ODD-paired-like
Short name:
Xopl
ZIC-related protein 1
Short name:
ZIC-r1
Zinc finger protein of the cerebellum 1
Gene namesi
Name:zic1
Synonyms:opl
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864815 zic1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472461 – 443Zinc finger protein ZIC 1Add BLAST443

Proteomic databases

PRIDEiO73689

Expressioni

Tissue specificityi

During early gastrula stages, widely expressed in the dorsal ectoderm. At mid-gastrula, expressed throughout the presumptive neural plate and at late gastrula, expression gradually diminishes in the dorsal midline and increases in the anterior folds. By early neurula stage, expression becomes restricted to the lateral edges of the neural plate, corresponding to the presumptive dorsal neural plate and neural crest, and in flanking ectoderm. In early tailbud stages (stages 22-23), expressed in the dorsal forebrain, midbrain and hindbrain. Subsequently expressed in the telencephalon and at the diencephalon/mesencephalon boundary. In the spinal cord, expression is restricted to the dorsal most region including the roof plate. Also expressed in the somites but not in eye vesicles. At larval stages, expressed mainly in the dorsal neural tube throughout its anteroposterior axis.7 Publications

Developmental stagei

Expressed zygotically from the blastula stage (stage 8) and peaks in the gastrula with lower expression persisting into tailbud stages.4 Publications

Inductioni

By chrd/chordin, zic1, zic2, zic3 and zic5. Suppressed by bmp signaling.3 Publications

Structurei

3D structure databases

ProteinModelPortaliO73689
SMRiO73689
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni408 – 443Negatively regulates transcriptional activityAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi71 – 74Poly-Ala4
Compositional biasi77 – 80Poly-His4

Domaini

The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation (By similarity). Removal of the C-terminal regulatory domain increases activity.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri221 – 256C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST36
Zinc fingeri265 – 292C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri298 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri328 – 352C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri358 – 380C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG007135
KOiK09224

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

O73689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLDAGAQYP AIGVTTFGSS RHHSAGDVTD REVALGINPF ADGMGAFKLN
60 70 80 90 100
PSSHDLASGQ TAFTSQAPGY AAAALGHHHH PGHVSSYSSA AFNSTRDFLF
110 120 130 140 150
RNRGFGEAAS AQHSLFASAA GGFPGPHGPH ADTTGHLIFP GLHEQAASHA
160 170 180 190 200
SPNVVNGQMR LGFSGDMYGR PDQYGQVTSP RSEHYASSQL HGYGPMNMNM
210 220 230 240 250
AAHHGAGAFF RYMRQPIKQE LICKWIEPEQ LANPKKSCNK TFSTMHELVT
260 270 280 290 300
HVTVEHVGGP EQSNHICVWE ECPREGKPFK AKYKLINHIR VHTGEKPFPC
310 320 330 340 350
PFPGCGKVFA RSENLKIHKR THTGEKPFKC EFEGCDRRFA NSSDRKKHMH
360 370 380 390 400
VHTSDKPYLC KMCDKSYTHP SSLRKHMKVH EASSQGSQPS PAASSGYESS
410 420 430 440
TPPTIVSPSA ENQSTSSLSP SSSAVHHTSN HSTLSSNFNE WYV
Length:443
Mass (Da):48,253
Last modified:August 1, 1998 - v1
Checksum:iE6E1CA481CF4C106
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → T in AAB99946 (PubMed:9655809).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022927 mRNA Translation: AAC14214.1
AF028805 mRNA Translation: AAB99946.1
AB009564 mRNA Translation: BAA33406.1
RefSeqiNP_001083799.1, NM_001090330.1
UniGeneiXl.1796

Genome annotation databases

GeneIDi399124
KEGGixla:399124

Similar proteinsi

Entry informationi

Entry nameiZIC1_XENLA
AccessioniPrimary (citable) accession number: O73689
Secondary accession number(s): O57461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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