Reviewed, UniProtKB/Swiss-Prot O73688 (HMOX_FUGRU)

Names and origin

Protein names

Recommended name:
    Heme oxygenase
      Short name=HO
    EC=1.14.99.3

Gene names

Name:

hmox

Organism

Fugu rubripes (Japanese pufferfish) (Takifugu rubripes)

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed By similarity.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Heme oxygenase		PRO_0000209697
Sites
	Metal binding	29	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	O73688-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 77B3584699963F77	FASTA	277	31,211
	10 20 30 40 50 60 MEADKKTTAQ TESNRDLSEQ IKKVTKDVHV RAESTELMLS FQRGQVTLQQ YKLLLCSLYE 70 80 90 100 110 120 IYLALEEEMD RNCDHPSVAP IYFPAELARL ATIEKDLEFF FGPDWREKIV VPAATERYCH 130 140 150 160 170 180 RIRQIGQENP EYLIAHAYTR YLGDLSGGQV LGRIAQKSMK LGGSEGLSFF AFPGVSSPNL 190 200 210 220 230 240 FKRLYRSRMN SVELTEEQRS AVLQEALGAF EFNIQVFEDL QKMLNVTENE PGVGTPRSRP 250 260 270 ATTLQVGGSM IQTNPLFRMV LGLCLALATV SIGLYAL

References

[1]

"The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors." Gottgens B., Gilbert J.G.R., Barton L.M., Aparicio S., Hawker K., Mistry S., Vaudin M., King A., Bentley D., Elgar G., Green A.R. Genomics 48:52-62(1998) [PubMed: 9503016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF022814 Genomic DNA. Translation: AAC41263.1.
3D structure databases
HSSP	HSSP built from PDB template 1N45 based on UniProtKB P09601.
ModBase	Search...
Phylogenomic databases
HOVERGEN	O73688.
Enzyme and pathway databases
BRENDA	1.14.99.3. 281122.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMOX_FUGRU

Accession

Primary (citable) accession number: O73688

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)