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O73688

- HMOX_TAKRU

UniProt

O73688 - HMOX_TAKRU

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Protein

Heme oxygenase

Gene

hmox

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed (By similarity).By similarity

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme oxidation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heme oxygenase (EC:1.14.99.3)
Short name:
HO
Gene namesi
Name:hmox
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226: Unplaced

Subcellular locationi

Microsome By similarity. Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Heme oxygenasePRO_0000209697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000011176.

Structurei

3D structure databases

ProteinModelPortaliO73688.
SMRiO73688. Positions 15-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG5398.
InParanoidiO73688.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view]
PANTHERiPTHR10720. PTHR10720. 1 hit.
PfamiPF01126. Heme_oxygenase. 1 hit.
[Graphical view]
PIRSFiPIRSF000343. Haem_Oase. 1 hit.
PRINTSiPR00088. HAEMOXYGNASE.
SUPFAMiSSF48613. SSF48613. 1 hit.
PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73688-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEADKKTTAQ TESNRDLSEQ IKKVTKDVHV RAESTELMLS FQRGQVTLQQ
60 70 80 90 100
YKLLLCSLYE IYLALEEEMD RNCDHPSVAP IYFPAELARL ATIEKDLEFF
110 120 130 140 150
FGPDWREKIV VPAATERYCH RIRQIGQENP EYLIAHAYTR YLGDLSGGQV
160 170 180 190 200
LGRIAQKSMK LGGSEGLSFF AFPGVSSPNL FKRLYRSRMN SVELTEEQRS
210 220 230 240 250
AVLQEALGAF EFNIQVFEDL QKMLNVTENE PGVGTPRSRP ATTLQVGGSM
260 270
IQTNPLFRMV LGLCLALATV SIGLYAL
Length:277
Mass (Da):31,211
Last modified:August 1, 1998 - v1
Checksum:i77B3584699963F77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022814 Genomic DNA. Translation: AAC41263.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022814 Genomic DNA. Translation: AAC41263.1 .

3D structure databases

ProteinModelPortali O73688.
SMRi O73688. Positions 15-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 31033.ENSTRUP00000011176.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5398.
InParanoidi O73688.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR002051. Haem_Oase.
IPR016053. Haem_Oase-like.
IPR016084. Haem_Oase-like_multi-hlx.
IPR018207. Haem_oxygenase_CS.
[Graphical view ]
PANTHERi PTHR10720. PTHR10720. 1 hit.
Pfami PF01126. Heme_oxygenase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000343. Haem_Oase. 1 hit.
PRINTSi PR00088. HAEMOXYGNASE.
SUPFAMi SSF48613. SSF48613. 1 hit.
PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors."
    Gottgens B., Gilbert J.G.R., Barton L.M., Aparicio S., Hawker K., Mistry S., Vaudin M., King A., Bentley D., Elgar G., Green A.R.
    Genomics 48:52-62(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHMOX_TAKRU
AccessioniPrimary (citable) accession number: O73688
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3