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O73686

- CP192_CARAU

UniProt

O73686 - CP192_CARAU

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Protein
Ovarian aromatase
Gene
cyp19a2
Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ovarian aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIXA2
    Cytochrome P-450AROM
    Cytochrome P450 19 type 2
    Estrogen synthase
    Gene namesi
    Name:cyp19a2
    OrganismiCarassius auratus (Goldfish)
    Taxonomic identifieri7957 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Ovarian aromatase
    PRO_0000051969Add
    BLAST

    Expressioni

    Tissue specificityi

    Ovarian specific.

    Structurei

    3D structure databases

    ProteinModelPortaliO73686.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O73686-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGELLQPCG MKQVHLGEAV LELLMQGAHN SSYGAQDNVC GAMATLLLLL    50
    LCLLLAIRHH WTEKDHVPGP CFLLGLGPLL SYCRFIWSGI GTASNYYNSK 100
    YGDIVRVWIN GEETLILSRS SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ 150
    GIIFNSNVAL WKKVRSFYAK ALTGPGLQRT LEICITSTNT HLDNLSHLMD 200
    ARGQVDILNL LRCIVVDISN RLFLGVPLNE HDLLQKIHKY FDTWQTVLIK 250
    PDVYFRLAWW LHRKHKRDAQ ELQDAIAALI EQKRVQLTRA EKFDQLDFTA 300
    ELIFAQSHGE LSTENVRQCV LEMIIAAPDT LSISLFFMLL LLKQNPDVEL 350
    KILQEMNAVL AGRSLQHSHL SGFHILESFI NESLRFHPVV DFTMRRALDD 400
    DVIEGYKVKR GTNIILNVGR MHRSEFFPKP NEFSLDNFQK NVPSRFFQPF 450
    GSGPRSCVGK HMAMVMMKSI LVTLLSRFSV CPVKGCTVDS IPQTNDLSQQ 500
    PVEEPSSLSV QLILRNAL 518
    Length:518
    Mass (Da):58,612
    Last modified:August 1, 1998 - v1
    Checksum:i004A9333D8952DEB
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851F → L in BAA23758. 1 Publication
    Sequence conflicti166 – 1661S → T in BAA23758. 1 Publication
    Sequence conflicti263 – 2631R → G in BAA23758. 1 Publication
    Sequence conflicti300 – 3001A → G in BAA23758. 1 Publication
    Sequence conflicti373 – 3731F → L in BAA23758. 1 Publication
    Sequence conflicti407 – 4071K → E in BAA23758. 1 Publication
    Sequence conflicti410 – 4101R → K in BAA23758. 1 Publication
    Sequence conflicti462 – 4621M → I in BAA23758. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020704 mRNA. Translation: AAC14013.1.
    AB009336 mRNA. Translation: BAA23758.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF020704 mRNA. Translation: AAC14013.1 .
    AB009336 mRNA. Translation: BAA23758.1 .

    3D structure databases

    ProteinModelPortali O73686.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary."
      Tchoudakova A., Callard G.V.
      Endocrinology 139:2179-2189(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
      Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP192_CARAU
    AccessioniPrimary (citable) accession number: O73686
    Secondary accession number(s): O57316
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: September 3, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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