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O73686

- CP192_CARAU

UniProt

O73686 - CP192_CARAU

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Protein

Ovarian aromatase

Gene
cyp19a2
Organism
Carassius auratus (Goldfish)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIXA2
Cytochrome P-450AROM
Cytochrome P450 19 type 2
Estrogen synthase
Gene namesi
Name:cyp19a2
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Ovarian aromatasePRO_0000051969Add
BLAST

Expressioni

Tissue specificityi

Ovarian specific.

Structurei

3D structure databases

ProteinModelPortaliO73686.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73686-1 [UniParc]FASTAAdd to Basket

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MAGELLQPCG MKQVHLGEAV LELLMQGAHN SSYGAQDNVC GAMATLLLLL    50
LCLLLAIRHH WTEKDHVPGP CFLLGLGPLL SYCRFIWSGI GTASNYYNSK 100
YGDIVRVWIN GEETLILSRS SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ 150
GIIFNSNVAL WKKVRSFYAK ALTGPGLQRT LEICITSTNT HLDNLSHLMD 200
ARGQVDILNL LRCIVVDISN RLFLGVPLNE HDLLQKIHKY FDTWQTVLIK 250
PDVYFRLAWW LHRKHKRDAQ ELQDAIAALI EQKRVQLTRA EKFDQLDFTA 300
ELIFAQSHGE LSTENVRQCV LEMIIAAPDT LSISLFFMLL LLKQNPDVEL 350
KILQEMNAVL AGRSLQHSHL SGFHILESFI NESLRFHPVV DFTMRRALDD 400
DVIEGYKVKR GTNIILNVGR MHRSEFFPKP NEFSLDNFQK NVPSRFFQPF 450
GSGPRSCVGK HMAMVMMKSI LVTLLSRFSV CPVKGCTVDS IPQTNDLSQQ 500
PVEEPSSLSV QLILRNAL 518
Length:518
Mass (Da):58,612
Last modified:August 1, 1998 - v1
Checksum:i004A9333D8952DEB
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851F → L in BAA23758. 1 Publication
Sequence conflicti166 – 1661S → T in BAA23758. 1 Publication
Sequence conflicti263 – 2631R → G in BAA23758. 1 Publication
Sequence conflicti300 – 3001A → G in BAA23758. 1 Publication
Sequence conflicti373 – 3731F → L in BAA23758. 1 Publication
Sequence conflicti407 – 4071K → E in BAA23758. 1 Publication
Sequence conflicti410 – 4101R → K in BAA23758. 1 Publication
Sequence conflicti462 – 4621M → I in BAA23758. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020704 mRNA. Translation: AAC14013.1.
AB009336 mRNA. Translation: BAA23758.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020704 mRNA. Translation: AAC14013.1 .
AB009336 mRNA. Translation: BAA23758.1 .

3D structure databases

ProteinModelPortali O73686.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG050750.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary."
    Tchoudakova A., Callard G.V.
    Endocrinology 139:2179-2189(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
    Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP192_CARAU
AccessioniPrimary (citable) accession number: O73686
Secondary accession number(s): O57316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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