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O73686 (CP192_CARAU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ovarian aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIXA2
Cytochrome P-450AROM
Cytochrome P450 19 type 2
Estrogen synthase
Gene names
Name:cyp19a2
OrganismCarassius auratus (Goldfish)
Taxonomic identifier7957 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Ovarian specific.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Ovarian aromatase
PRO_0000051969

Sites

Metal binding4571Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict851F → L in BAA23758. Ref.2
Sequence conflict1661S → T in BAA23758. Ref.2
Sequence conflict2631R → G in BAA23758. Ref.2
Sequence conflict3001A → G in BAA23758. Ref.2
Sequence conflict3731F → L in BAA23758. Ref.2
Sequence conflict4071K → E in BAA23758. Ref.2
Sequence conflict4101R → K in BAA23758. Ref.2
Sequence conflict4621M → I in BAA23758. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O73686 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 004A9333D8952DEB

FASTA51858,612
        10         20         30         40         50         60 
MAGELLQPCG MKQVHLGEAV LELLMQGAHN SSYGAQDNVC GAMATLLLLL LCLLLAIRHH 

        70         80         90        100        110        120 
WTEKDHVPGP CFLLGLGPLL SYCRFIWSGI GTASNYYNSK YGDIVRVWIN GEETLILSRS 

       130        140        150        160        170        180 
SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ GIIFNSNVAL WKKVRSFYAK ALTGPGLQRT 

       190        200        210        220        230        240 
LEICITSTNT HLDNLSHLMD ARGQVDILNL LRCIVVDISN RLFLGVPLNE HDLLQKIHKY 

       250        260        270        280        290        300 
FDTWQTVLIK PDVYFRLAWW LHRKHKRDAQ ELQDAIAALI EQKRVQLTRA EKFDQLDFTA 

       310        320        330        340        350        360 
ELIFAQSHGE LSTENVRQCV LEMIIAAPDT LSISLFFMLL LLKQNPDVEL KILQEMNAVL 

       370        380        390        400        410        420 
AGRSLQHSHL SGFHILESFI NESLRFHPVV DFTMRRALDD DVIEGYKVKR GTNIILNVGR 

       430        440        450        460        470        480 
MHRSEFFPKP NEFSLDNFQK NVPSRFFQPF GSGPRSCVGK HMAMVMMKSI LVTLLSRFSV 

       490        500        510 
CPVKGCTVDS IPQTNDLSQQ PVEEPSSLSV QLILRNAL 

« Hide

References

[1]"Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary."
Tchoudakova A., Callard G.V.
Endocrinology 139:2179-2189(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF020704 mRNA. Translation: AAC14013.1.
AB009336 mRNA. Translation: BAA23758.1.

3D structure databases

ProteinModelPortalO73686.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP192_CARAU
AccessionPrimary (citable) accession number: O73686
Secondary accession number(s): O57316
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 22, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families