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Protein

Ovarian aromatase

Gene

cyp19a2

Organism
Carassius auratus (Goldfish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi457 – 4571Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ovarian aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIXA2
Cytochrome P-450AROM
Cytochrome P450 19 type 2
Estrogen synthase
Gene namesi
Name:cyp19a2
OrganismiCarassius auratus (Goldfish)
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Ovarian aromatasePRO_0000051969Add
BLAST

Expressioni

Tissue specificityi

Ovarian specific.

Structurei

3D structure databases

ProteinModelPortaliO73686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73686-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGELLQPCG MKQVHLGEAV LELLMQGAHN SSYGAQDNVC GAMATLLLLL
60 70 80 90 100
LCLLLAIRHH WTEKDHVPGP CFLLGLGPLL SYCRFIWSGI GTASNYYNSK
110 120 130 140 150
YGDIVRVWIN GEETLILSRS SAVYHVLRKS LYTSRFGSKL GLQCIGMHEQ
160 170 180 190 200
GIIFNSNVAL WKKVRSFYAK ALTGPGLQRT LEICITSTNT HLDNLSHLMD
210 220 230 240 250
ARGQVDILNL LRCIVVDISN RLFLGVPLNE HDLLQKIHKY FDTWQTVLIK
260 270 280 290 300
PDVYFRLAWW LHRKHKRDAQ ELQDAIAALI EQKRVQLTRA EKFDQLDFTA
310 320 330 340 350
ELIFAQSHGE LSTENVRQCV LEMIIAAPDT LSISLFFMLL LLKQNPDVEL
360 370 380 390 400
KILQEMNAVL AGRSLQHSHL SGFHILESFI NESLRFHPVV DFTMRRALDD
410 420 430 440 450
DVIEGYKVKR GTNIILNVGR MHRSEFFPKP NEFSLDNFQK NVPSRFFQPF
460 470 480 490 500
GSGPRSCVGK HMAMVMMKSI LVTLLSRFSV CPVKGCTVDS IPQTNDLSQQ
510
PVEEPSSLSV QLILRNAL
Length:518
Mass (Da):58,612
Last modified:August 1, 1998 - v1
Checksum:i004A9333D8952DEB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851F → L in BAA23758. 1 PublicationCurated
Sequence conflicti166 – 1661S → T in BAA23758. 1 PublicationCurated
Sequence conflicti263 – 2631R → G in BAA23758. 1 PublicationCurated
Sequence conflicti300 – 3001A → G in BAA23758. 1 PublicationCurated
Sequence conflicti373 – 3731F → L in BAA23758. 1 PublicationCurated
Sequence conflicti407 – 4071K → E in BAA23758. 1 PublicationCurated
Sequence conflicti410 – 4101R → K in BAA23758. 1 PublicationCurated
Sequence conflicti462 – 4621M → I in BAA23758. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020704 mRNA. Translation: AAC14013.1.
AB009336 mRNA. Translation: BAA23758.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020704 mRNA. Translation: AAC14013.1.
AB009336 mRNA. Translation: BAA23758.1.

3D structure databases

ProteinModelPortaliO73686.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of multiple CYP19 genes encoding different cytochrome P450 aromatase isozymes in brain and ovary."
    Tchoudakova A., Callard G.V.
    Endocrinology 139:2179-2189(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "Two differing cDNAs encoding cytochrome P450arom (aromatase) exist in goldfish."
    Sudrajat A., Yoshiura Y., Gen K., Suetake H., Aida K.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP192_CARAU
AccessioniPrimary (citable) accession number: O73686
Secondary accession number(s): O57316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.