Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

G protein-coupled receptor kinase

Gene

GRK1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei347Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.14 1306

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinaseUniRule annotation (EC:2.7.11.-UniRule annotation)
Gene namesi
Name:GRK1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Structurei

3D structure databases

ProteinModelPortaliO73685
SMRiO73685
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 205RGSInterPro annotationAdd BLAST110
Domaini220 – 485Protein kinaseInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG004532
KOiK00909
PhylomeDBiO73685

Family and domain databases

CDDicd05608 STKc_GRK1, 1 hit
InterProiView protein in InterPro
IPR000239 GPCR_kinase
IPR037716 GRK1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O73685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGGLETVV ANSAYVSARG GGPGGSARDR KHRARLRLPH ISQCEALRAR
60 70 80 90 100
LAGGGLQNGV AQQDGGPKQD GGPKQDGGPK QDGGGEEEAS FRWQCVEQPI
110 120 130 140 150
GKRLFRQFLQ ATPGLAAAGA LWEELEAFEC CEEGERSAAA ANIRKRFFTE
160 170 180 190 200
GGAEHCAFLS AAATAPPADS GAPDDFEPTR RELLAHLEGT AWAPYLSSPY
210 220 230 240 250
FGRFTQFKWL EGQPVGADAF ADFRVLGKGG FGKVCACQRR ATGKMYANKK
260 270 280 290 300
LNKKRLKKRQ GYEAAMVEKR ILARVHSRFI VSLACAFQTK TDLCLVMTLM
310 320 330 340 350
NGGDLRYHVY NVDEENPGFP EPRAVFYTAQ ILLGLEHLHQ HRIVYRDLKP
360 370 380 390 400
ENVLLDDAGH VRLSDMGLAV ELKDGQNKTR GYAGTPGFMA PEVLRDEEYD
410 420 430 440 450
MAVDYFTLGV TLYEMLDAKG PFRRRGEKVE KKEVTRRTLH DSVSYSERFS
460 470 480 490 500
AASRSLCEGL LAKDPQKRLG FRDGNCAMLR SQPVFSALHW GSWSGPPPPP
510 520 530 540 550
FVPDPRRVYA KDLGDVGAFS TVRGVELDGA DAALCDAFAS GTVSIPWQEE
560 570 580 590
LIETGLFDEL NVWGGDGRLP PDLDPNAEPG SGGGTRSATC GVL
Length:593
Mass (Da):64,660
Last modified:August 1, 1998 - v1
Checksum:i035B9E169E22C411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019766 mRNA Translation: AAC08428.1
RefSeqiNP_990026.1, NM_204695.1
UniGeneiGga.233

Genome annotation databases

GeneIDi395431
KEGGigga:395431

Similar proteinsi

Entry informationi

Entry nameiO73685_CHICK
AccessioniPrimary (citable) accession number: O73685
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health