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Protein

Rhodopsin kinase

Gene

GRK1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.UniRule annotation

Catalytic activityi

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei347Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Biological processi

Sensory transductionUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.14. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Rhodopsin kinaseUniRule annotation (EC:2.7.11.14UniRule annotation)
Alternative name(s):
G protein-coupled receptor kinase 1UniRule annotation
Gene namesi
Name:GRK1Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Interactioni

Subunit structurei

Interacts (when prenylated) with PDE6D; this promotes release from membranes.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO73685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 205RGSInterPro annotationAdd BLAST110
Domaini220 – 485Protein kinaseInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation
Contains 1 RGS domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG004532.
KOiK00909.
PhylomeDBiO73685.

Family and domain databases

InterProiIPR000239. GPCR_kinase.
IPR032965. GRK1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24355:SF11. PTHR24355:SF11. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGGLETVV ANSAYVSARG GGPGGSARDR KHRARLRLPH ISQCEALRAR
60 70 80 90 100
LAGGGLQNGV AQQDGGPKQD GGPKQDGGPK QDGGGEEEAS FRWQCVEQPI
110 120 130 140 150
GKRLFRQFLQ ATPGLAAAGA LWEELEAFEC CEEGERSAAA ANIRKRFFTE
160 170 180 190 200
GGAEHCAFLS AAATAPPADS GAPDDFEPTR RELLAHLEGT AWAPYLSSPY
210 220 230 240 250
FGRFTQFKWL EGQPVGADAF ADFRVLGKGG FGKVCACQRR ATGKMYANKK
260 270 280 290 300
LNKKRLKKRQ GYEAAMVEKR ILARVHSRFI VSLACAFQTK TDLCLVMTLM
310 320 330 340 350
NGGDLRYHVY NVDEENPGFP EPRAVFYTAQ ILLGLEHLHQ HRIVYRDLKP
360 370 380 390 400
ENVLLDDAGH VRLSDMGLAV ELKDGQNKTR GYAGTPGFMA PEVLRDEEYD
410 420 430 440 450
MAVDYFTLGV TLYEMLDAKG PFRRRGEKVE KKEVTRRTLH DSVSYSERFS
460 470 480 490 500
AASRSLCEGL LAKDPQKRLG FRDGNCAMLR SQPVFSALHW GSWSGPPPPP
510 520 530 540 550
FVPDPRRVYA KDLGDVGAFS TVRGVELDGA DAALCDAFAS GTVSIPWQEE
560 570 580 590
LIETGLFDEL NVWGGDGRLP PDLDPNAEPG SGGGTRSATC GVL
Length:593
Mass (Da):64,660
Last modified:August 1, 1998 - v1
Checksum:i035B9E169E22C411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019766 mRNA. Translation: AAC08428.1.
RefSeqiNP_990026.1. NM_204695.1.
UniGeneiGga.233.

Genome annotation databases

GeneIDi395431.
KEGGigga:395431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019766 mRNA. Translation: AAC08428.1.
RefSeqiNP_990026.1. NM_204695.1.
UniGeneiGga.233.

3D structure databases

ProteinModelPortaliO73685.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395431.
KEGGigga:395431.

Organism-specific databases

CTDi6011.

Phylogenomic databases

HOVERGENiHBG004532.
KOiK00909.
PhylomeDBiO73685.

Enzyme and pathway databases

BRENDAi2.7.11.14. 1306.

Family and domain databases

InterProiIPR000239. GPCR_kinase.
IPR032965. GRK1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24355:SF11. PTHR24355:SF11. 2 hits.
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO73685_CHICK
AccessioniPrimary (citable) accession number: O73685
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.