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Protein
Submitted name:

25-hydroxyvitamin D3 24-hydroxylase

Gene

cP450cc24

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • bone regeneration Source: AgBase
  • vitamin D3 catabolic process Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKO73684.

Names & Taxonomyi

Protein namesi
Submitted name:
25-hydroxyvitamin D3 24-hydroxylaseImported
Gene namesi
Name:cP450cc24Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

PTM / Processingi

Proteomic databases

PaxDbiO73684.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012629.

Structurei

3D structure databases

ProteinModelPortaliO73684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000276540.
HOVERGENiHBG099053.
KOiK07436.
PhylomeDBiO73684.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCSILLRS SALTCGRPRS SPPGAEVRCR GRRPLCALRG RGHPLAALPG
60 70 80 90 100
PPSWPLMGSL PDVLWKGGLK RQHETLAEYH RRFGKIFRMK LGAFDSVHIG
110 120 130 140 150
APCLLESLYR RESSCPQRLE IKPWKAYRDY RDEGYGLLIL EGKDWQRVRS
160 170 180 190 200
AFQKKLMKPK EVVKLDNTIN EVLEDFMHRI DEICNHNGQM EDVYSEFNKW
210 220 230 240 250
SFESICLVLY GKRFGLLQQD VEEESLNFIK AVKTMMATFG MMMVTPVELH
260 270 280 290 300
KGLNTKVWQA HTKAWDDIFK TAKHSIDSRL QRHSANPQED FLCDIYSGGQ
310 320 330 340 350
LSKKELYATI AELQIAGVET TANSLLWALY NISRNPHVQQ KLLQEIQSVL
360 370 380 390 400
AANESPTAES IKNMPYLKAC LKESMRLTPS VPFTTRTIDT EMVLGDYVLP
410 420 430 440 450
EGTVLMINSY ALGCNEEYFN GWTQFKPERR WLQKHSINPF SHVPFGIGKR
460 470 480 490 500
MCIGRRLAEL QLHLALCWII RKYQLVATDD NPVETLHSGI LIPSRELPIA

FHRRLQLD
Length:508
Mass (Da):58,128
Last modified:August 1, 1998 - v1
Checksum:i8C0DB4EBBE2CBAD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019142 mRNA. Translation: AAC41266.1.
RefSeqiNP_990310.1. NM_204979.1.
UniGeneiGga.893.

Genome annotation databases

GeneIDi395827.
KEGGigga:395827.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019142 mRNA. Translation: AAC41266.1.
RefSeqiNP_990310.1. NM_204979.1.
UniGeneiGga.893.

3D structure databases

ProteinModelPortaliO73684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012629.

Proteomic databases

PaxDbiO73684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395827.
KEGGigga:395827.

Organism-specific databases

CTDi1591.

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000276540.
HOVERGENiHBG099053.
KOiK07436.
PhylomeDBiO73684.

Enzyme and pathway databases

SABIO-RKO73684.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO73684_CHICK
AccessioniPrimary (citable) accession number: O73684
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.