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Protein

Amyloid beta A4 protein

Gene

app

Organism
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi148 – 1481CopperBy similarity
Metal bindingi152 – 1521CopperBy similarity
Metal bindingi169 – 1691CopperBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Beta-amyloid precursor proteinCurated
Cleaved into the following chain:
Alternative name(s):
A-beta
Beta-APP
Gene namesi
Name:app
OrganismiTetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
Taxonomic identifieri47145 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 711693ExtracellularSequence analysisAdd
BLAST
Transmembranei712 – 73221HelicalSequence analysisAdd
BLAST
Topological domaini733 – 78048CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 780762Amyloid beta A4 proteinPRO_0000000199Add
BLAST
Chaini682 – 72443Beta-amyloid proteinSequence analysisPRO_0000000200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 63PROSITE-ProRule annotation
Disulfide bondi74 ↔ 118PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi134 ↔ 188PROSITE-ProRule annotation
Disulfide bondi145 ↔ 175PROSITE-ProRule annotation
Disulfide bondi159 ↔ 187PROSITE-ProRule annotation
Disulfide bondi327 ↔ 378PROSITE-ProRule annotation
Disulfide bondi336 ↔ 361PROSITE-ProRule annotation
Glycosylationi560 – 5601N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO73683.
SMRiO73683. Positions 29-124, 392-583, 691-716, 749-780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini323 – 38260BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni769 – 7724Clathrin-bindingBy similarity

Sequence similaritiesi

Belongs to the APP family.Curated
Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O73683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHSVAWLLL VAAASTLAAE VPTDVSMGLL AEPQVAMFCG KINMHINVQS
60 70 80 90 100
GKWEPDPSGT KSCIGTKEGI LQYCQEVYPE LQITNVVEAN QPVSIQNWCK
110 120 130 140 150
KGRKQCRSHM HIVVPYRCLV GEFVSDALLV PDKCKFLHQE RMNQCESHLH
160 170 180 190 200
WHTVAKESCG DRAMNLHDYG MLLPCGIDRF RGVEFVCCPA EAERDMDSTE
210 220 230 240 250
KDADDSDVWW GGADNDYSDN SMVREPEPAE QQEETRPSVV EEEEEGEVAQ
260 270 280 290 300
EDDEEEEEVL DTDQDGDGEE DHEAADDEEE EEDVDEIDAF GESDDVDADE
310 320 330 340 350
PTTNVAMTTT TTTTTTESVE EVVRMFCWAH ADTGPCTASM PSWYFDAVDG
360 370 380 390 400
RTMYELMYGG CGGNMNNFES EEYCLSVCSS VVPTDMPSSP DAVDHYLETP
410 420 430 440 450
ADENEHAHFQ KAKESLEAKH RERMSQVMRE WEEAERQAKN LPRADKKIVI
460 470 480 490 500
QRFQEKVEAL EQEAASERQQ LVETHMARVE ALLNDRRRLA LENYLTALQQ
510 520 530 540 550
DPPRPRHVFS LLKKYVRAEQ KDRQHTLKHF EHVRMVDPKK AAQIRPQVLT
560 570 580 590 600
HLRVIEERMN QSLGLLYKVP GVADDIQDQV ELLQREQAEM AQQLANLQTD
610 620 630 640 650
VRVSYGNDAL MPDQELGDGQ ADLLPQEDTL GGVGFVHPES FNQLNTENQV
660 670 680 690 700
EPVDSRPTFE RGVPTRPVTG KSMEAVPELR METEDRQSTE YEVHHQKLVF
710 720 730 740 750
FAEDVGSNKG AIIGLMVGGV VIATVIVITL VMLRKKQYTS IHHGIIEVDA
760 770 780
AVTPEERHLS KMQQNGYENP TYKFFEQMQN
Length:780
Mass (Da):88,238
Last modified:August 1, 1998 - v1
Checksum:i60071BE94520191D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018165 mRNA. Translation: AAC41275.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018165 mRNA. Translation: AAC41275.1.

3D structure databases

ProteinModelPortaliO73683.
SMRiO73683. Positions 29-124, 392-583, 691-716, 749-780.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG000051.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of pufferfish homologues of the AT-rich human APP gene."
    Villard L., Tassone F., Crnogorac-Jurcevic T., Clancy K., Gardiner K.
    Gene 210:17-24(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiA4_TETFL
AccessioniPrimary (citable) accession number: O73683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: August 1, 1998
Last modified: February 17, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.