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Protein
Submitted name:

Melanocortin 5 receptor

Gene

MC5R

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 5 receptorImported
Submitted name:
Melanocortin 5-receptorImported
Gene namesi
Name:MC5RImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5924HelicalSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13822HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei185 – 21026HelicalSequence analysisAdd
BLAST
Transmembranei237 – 25923HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29719HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 295243G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
KOiK04203.
PhylomeDBiO73671.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSSQLYVS ELNLSAFGSN FTVPTVKSKS SPCEQVVIAA EVFLILGIVS
60 70 80 90 100
LLENILVICA IVKNKNLHSP MYFFVCSLAV ADMLVSVSNA WETITIYLIN
110 120 130 140 150
NRHIIMEDAF VRHIDNVFDS LICISVVASM CSLLAIAVDR YITIFYALRY
160 170 180 190 200
HNIMTVKRSG LIIACIWTFC TGCGIIFILY YESTYVIICL ITMFFTMLFL
210 220 230 240 250
MVSLYIHMFL LARTHVKKIA ALPGYNSVHQ RTSMKGAITL TMLLGIFIVC
260 270 280 290 300
WAPFFLHLIL MISCPQNLYC VCFMSHFNMY LILIMCNSVI DPLIYAFRSQ
310 320
EMRKTFKEII CCYSVRMVCG LSNKY
Length:325
Mass (Da):36,995
Last modified:August 1, 1998 - v1
Checksum:i35441907C71E4FA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF670718 mRNA. Translation: AHC02482.1.
AB012868 Genomic DNA. Translation: BAA25640.1.
RefSeqiNP_001026186.1. NM_001031015.1.
UniGeneiGga.14272.
Gga.52952.

Genome annotation databases

GeneIDi421047.
KEGGigga:421047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF670718 mRNA. Translation: AHC02482.1.
AB012868 Genomic DNA. Translation: BAA25640.1.
RefSeqiNP_001026186.1. NM_001031015.1.
UniGeneiGga.14272.
Gga.52952.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030308.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi421047.
KEGGigga:421047.

Organism-specific databases

CTDi4161.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
KOiK04203.
PhylomeDBiO73671.

Miscellaneous databases

PROiO73671.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001908. Melancort_rcpt.
IPR000621. Melancort_rcpt_5.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF5. PTHR22750:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01063. MELNOCORTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the chicken melanocortin 5-receptor gene."
    Takeuchi S., Takahashi S.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White leghoneImported.
    Tissue: LiverImported.
  2. "Interference between AvBD6 and ACTH mediated by MC5R modulates lymphocytes growth."
    Peng K.S.
    Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Peripheral blood lymphocytesImported.

Entry informationi

Entry nameiO73671_CHICK
AccessioniPrimary (citable) accession number: O73671
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.