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Protein
Submitted name:

Melanocortin 4-receptor

Gene

MC4R

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 4-receptorImported
Gene namesi
Name:MC4RImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6820HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10324HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14422HelicalSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21424HelicalSequence analysisAdd
BLAST
Transmembranei243 – 26826HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021014.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 301242G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
PhylomeDBiO73667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTQHRGTL QPLHFWNQSN GLHRGASEPS AKGHSSGGCY EQLFVSPEVF
60 70 80 90 100
VTLGIISLLE NVLVIVAIAK NKNLHSPMYF FICSLAVADM LVSVSNGSET
110 120 130 140 150
IVITLLNNTD TDAQSFTINI DNVIDSVICS SLLASICSLL SIAVDRYFTI
160 170 180 190 200
FYALQYHNIM TVKRVGVIIT CIWAACTVSG ILFIIYSDSS VVIICLISMF
210 220 230 240 250
FTMLILMASL YVHMFMMARM HIKKIAVLPG TGPIRQGANM KGAITLTILI
260 270 280 290 300
GVFVVCWAPF FLHLIFYISC PYNPYCVCFM SHFNFYLILI MCNSIIDPLI
310 320 330
YAFRSQELRK TFKEIICCCN LRGLCDLPGK Y
Length:331
Mass (Da):36,984
Last modified:August 1, 1998 - v1
Checksum:i98B25F5A1FFB02C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN648095 Genomic DNA. Translation: AEP17333.1.
JN648096 Genomic DNA. Translation: AEP17334.1.
AB012211 Genomic DNA. Translation: BAA25252.1.
UniGeneiGga.32096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN648095 Genomic DNA. Translation: AEP17333.1.
JN648096 Genomic DNA. Translation: AEP17334.1.
AB012211 Genomic DNA. Translation: BAA25252.1.
UniGeneiGga.32096.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021014.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.
PhylomeDBiO73667.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Melanocortin receptor genes in the chicken--tissue distributions."
    Takeuchi S., Takahashi S.
    Gen. Comp. Endocrinol. 112:220-231(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: White LeghoneImported.
    Tissue: LiverImported.
  2. "Molecular genetic studies on genes associated with growth in poultry."
    Ekhtiari Sadegh M., Nagaraja C.S., Jayashankar M.R., Murthy H.N.N., Umakantha B., Isloor S.
    Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BloodImported.

Entry informationi

Entry nameiO73667_CHICK
AccessioniPrimary (citable) accession number: O73667
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.