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Protein
Submitted name:

Melanocortin 4-receptor

Gene

MC4R

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 4-receptorImported
Gene namesi
Name:MC4RImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 68HelicalSequence analysisAdd BLAST20
Transmembranei80 – 103HelicalSequence analysisAdd BLAST24
Transmembranei123 – 144HelicalSequence analysisAdd BLAST22
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei191 – 214HelicalSequence analysisAdd BLAST24
Transmembranei243 – 268HelicalSequence analysisAdd BLAST26
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 301G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST242

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000246927.
HOVERGENiHBG108148.

Family and domain databases

CDDicd15353. 7tmA_MC4R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000155. Mcort_rcpt_4.
IPR001908. Melancort_rcpt.
IPR001671. Melcrt_ACTH_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00534. MCRFAMILY.
PR00535. MELNOCORTINR.
PR01062. MELNOCORTN4R.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O73667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFTQHRGTL QPLHFWNQSN GLHRGASEPS AKGHSSGGCY EQLFVSPEVF
60 70 80 90 100
VTLGIISLLE NVLVIVAIAK NKNLHSPMYF FICSLAVADM LVSVSNGSET
110 120 130 140 150
IVITLLNNTD TDAQSFTINI DNVIDSVICS SLLASICSLL SIAVDRYFTI
160 170 180 190 200
FYALQYHNIM TVKRVGVIIT CIWAACTVSG ILFIIYSDSS VVIICLISMF
210 220 230 240 250
FTMLILMASL YVHMFMMARM HIKKIAVLPG TGPIRQGANM KGAITLTILI
260 270 280 290 300
GVFVVCWAPF FLHLIFYISC PYNPYCVCFM SHFNFYLILI MCNSIIDPLI
310 320 330
YAFRSQELRK TFKEIICCCN LRGLCDLPGK Y
Length:331
Mass (Da):36,984
Last modified:August 1, 1998 - v1
Checksum:i98B25F5A1FFB02C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN648095 Genomic DNA. Translation: AEP17333.1.
JN648096 Genomic DNA. Translation: AEP17334.1.
AB012211 Genomic DNA. Translation: BAA25252.1.
UniGeneiGga.32096.

Similar proteinsi

Entry informationi

Entry nameiO73667_CHICK
AccessioniPrimary (citable) accession number: O73667
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)