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Protein

Rhodopsin kinase

Gene

grk1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.UniRule annotation

Catalytic activityi

ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Sensory transductionUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhodopsin kinaseUniRule annotation (EC:2.7.11.14UniRule annotation)
Alternative name(s):
G protein-coupled receptor kinase 1UniRule annotation
Gene namesi
Name:grk1Imported
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Chromosome 3

Subcellular locationi

  • Membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Interactioni

Subunit structurei

Interacts (when prenylated) with PDE6D; this promotes release from membranes.UniRule annotation

Protein-protein interaction databases

STRINGi8090.ENSORLP00000005942.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 176113RGSInterPro annotationAdd
BLAST
Domaini191 – 456266Protein kinaseInterPro annotationAdd
BLAST
Domaini457 – 52266AGC-kinase C-terminalInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation
Contains 1 RGS domain.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
KOiK00909.
OMAiKSGMCLV.
OrthoDBiEOG7TF78J.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR032965. GRK1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24355:SF11. PTHR24355:SF11. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGGLTTVV ANSAYISARG SFDGTANPAA NRDKKFHSRL KLPHITVCEG
60 70 80 90 100
LRETLDLGFQ TVCVEQPIGK RLFQEFLDSI NEYKGPSRLW KDIEEYNMAE
110 120 130 140 150
DEDRAKKASK ILSRYMEPDA KHYCPFLPEN GITKVKEKHK EAGDELFSET
160 170 180 190 200
MDSVMDFLKE VPYTFFLESM YLKRFLQWKW LEMQPIGEDW FLDFRVLGKG
210 220 230 240 250
GFGEVSACQM RATGKLYACK KLNKKRLKKR KGYEGAMVEK RILARVHSRF
260 270 280 290 300
IVSLAYAFQS KTELCLVMTI MNGGDLRYHI YNVDENNPGF DEPRACYYAA
310 320 330 340 350
QIIQGLEHLH QKRIIYRDLK PENVLLDNEG HVRISDLGLA VELADDQFKI
360 370 380 390 400
KGYAGTPGFM APELLNGEEY DYCVDYFTLG VTLYEFLAAK GPFRTRGEKV
410 420 430 440 450
ENKVVKKRIL NDPVTYPEKF SENGKSICEG LLCKEADKRL GFKNGSCDEL
460 470 480 490 500
RTHPFFSQIN WRKLNAGILP PPFVPDSKTV YAKDLDDVGA FSTVKGVQLE
510 520 530 540 550
DVDTVFFDEF ASGNIAIPWQ EEMIETGIYG ELTVWGPGGA LPNDLRRESI
560
LEQPPKSSTC CAS
Length:563
Mass (Da):64,002
Last modified:August 1, 1998 - v1
Checksum:iE84C0269FDF294F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAAF04006758 Genomic DNA. No translation available.
BAAF04006759 Genomic DNA. No translation available.
AB009569 mRNA. Translation: BAA25671.1.
RefSeqiNP_001188419.1. NM_001201490.1.
UniGeneiOla.76.

Genome annotation databases

EnsembliENSORLT00000005943; ENSORLP00000005942; ENSORLG00000004724.
GeneIDi100529155.
KEGGiola:100529155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAAF04006758 Genomic DNA. No translation available.
BAAF04006759 Genomic DNA. No translation available.
AB009569 mRNA. Translation: BAA25671.1.
RefSeqiNP_001188419.1. NM_001201490.1.
UniGeneiOla.76.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000005942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSORLT00000005943; ENSORLP00000005942; ENSORLG00000004724.
GeneIDi100529155.
KEGGiola:100529155.

Organism-specific databases

CTDi6011.

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
HOVERGENiHBG004532.
KOiK00909.
OMAiKSGMCLV.
OrthoDBiEOG7TF78J.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR032965. GRK1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24355:SF11. PTHR24355:SF11. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel subtype of G-protein-coupled receptor kinase, GRK7, in teleost cone photoreceptors."
    Hisatomi O., Matsuda S., Satoh T., Kotaka S., Imanishi Y., Tokunaga F.
    FEBS Lett. 424:159-164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hd-rRImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Hd-rRImported.

Entry informationi

Entry nameiO73659_ORYLA
AccessioniPrimary (citable) accession number: O73659
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.