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Protein

G protein-coupled receptor kinase

Gene

grk1

Organism
Oryzias latipes (Japanese rice fish) (Japanese killifish)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinaseUniRule annotation (EC:2.7.11.-UniRule annotation)
Gene namesi
Name:grk1Imported
OrganismiOryzias latipes (Japanese rice fish) (Japanese killifish)Imported
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
Proteomesi
  • UP000001038 Componenti: Chromosome 3

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000005942

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 176RGSInterPro annotationAdd BLAST113
Domaini191 – 456Protein kinaseInterPro annotationAdd BLAST266
Domaini457 – 522AGC-kinase C-terminalInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0986 Eukaryota
ENOG410YRQZ LUCA
GeneTreeiENSGT00860000133699
HOGENOMiHOG000006742
HOVERGENiHBG004532
KOiK00909
OMAiKSGMCLV
OrthoDBiEOG091G062G
TreeFamiTF313940

Family and domain databases

CDDicd05608 STKc_GRK1, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR000239 GPCR_kinase
IPR032965 GRK1
IPR037716 GRK1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR016137 RGS
IPR036305 RGS_sf
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24355:SF11 PTHR24355:SF11, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR00717 GPCRKINASE
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O73659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGGLTTVV ANSAYISARG SFDGTANPAA NRDKKFHSRL KLPHITVCEG
60 70 80 90 100
LRETLDLGFQ TVCVEQPIGK RLFQEFLDSI NEYKGPSRLW KDIEEYNMAE
110 120 130 140 150
DEDRAKKASK ILSRYMEPDA KHYCPFLPEN GITKVKEKHK EAGDELFSET
160 170 180 190 200
MDSVMDFLKE VPYTFFLESM YLKRFLQWKW LEMQPIGEDW FLDFRVLGKG
210 220 230 240 250
GFGEVSACQM RATGKLYACK KLNKKRLKKR KGYEGAMVEK RILARVHSRF
260 270 280 290 300
IVSLAYAFQS KTELCLVMTI MNGGDLRYHI YNVDENNPGF DEPRACYYAA
310 320 330 340 350
QIIQGLEHLH QKRIIYRDLK PENVLLDNEG HVRISDLGLA VELADDQFKI
360 370 380 390 400
KGYAGTPGFM APELLNGEEY DYCVDYFTLG VTLYEFLAAK GPFRTRGEKV
410 420 430 440 450
ENKVVKKRIL NDPVTYPEKF SENGKSICEG LLCKEADKRL GFKNGSCDEL
460 470 480 490 500
RTHPFFSQIN WRKLNAGILP PPFVPDSKTV YAKDLDDVGA FSTVKGVQLE
510 520 530 540 550
DVDTVFFDEF ASGNIAIPWQ EEMIETGIYG ELTVWGPGGA LPNDLRRESI
560
LEQPPKSSTC CAS
Length:563
Mass (Da):64,002
Last modified:August 1, 1998 - v1
Checksum:iE84C0269FDF294F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BAAF04006758 Genomic DNA No translation available.
BAAF04006759 Genomic DNA No translation available.
AB009569 mRNA Translation: BAA25671.1
RefSeqiNP_001188419.1, NM_001201490.1
UniGeneiOla.76

Genome annotation databases

EnsembliENSORLT00000005943; ENSORLP00000005942; ENSORLG00000004724
GeneIDi100529155
KEGGiola:100529155

Similar proteinsi

Entry informationi

Entry nameiO73659_ORYLA
AccessioniPrimary (citable) accession number: O73659
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health