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Protein
Submitted name:

Neural cell adhesion molecule

Gene

N-CAM 2

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neural cell adhesion moleculeImported
Gene namesi
Name:N-CAM 2Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 725706Sequence analysisPRO_5004159933Add
BLAST

Proteomic databases

PRIDEiO73634.

Structurei

3D structure databases

ProteinModelPortaliO73634.
SMRiO73634. Positions 20-302, 488-694.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10889Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini113 – 18674Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini208 – 29588Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini303 – 39795Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini400 – 48990Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini493 – 592100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini600 – 69697Fibronectin type-IIIInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG052579.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O73634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHIKDLIWT LYFIGAAVAL EVTIVPDQGE ISLGESKFFL CQVSGEATDI
60 70 80 90 100
SWYSPTGEKL LNQQQISVVK NDEYTSTLTI YNVSSQDAGI YKCVASSETE
110 120 130 140 150
GESEGTVNLK IYQKLTFKYA PTPQEFTEGE DAVIICDVSS SIPSIITWRH
160 170 180 190 200
KGKDVIFKKD VRFVVLANNY LQIRGIKKTD EGNYRCEGRI LARGEINYKD
210 220 230 240 250
IQVIVNVPPL IQARQIRVNA TANMDESVVL SCDADGFPDP EISWLKKGEP
260 270 280 290 300
IEDGEEKISF NEDKSEMTIY RVEKEDEAEY SCIANNQAGE AEAIVLLKVY
310 320 330 340 350
AKPKITYVEN KTAVELDEIT LTCEASGDPI PSITWRTAHR NISSEEKTLD
360 370 380 390 400
GHIVVKDHIR MSALTLKDIQ YTDAGEYFCV ASNPIGVDMQ AMYFEVQYAP
410 420 430 440 450
KIRGPVVVYT WEGNPVNITC DVLAHPSAAV SWFRDGQLLP SSNFSNIKIY
460 470 480 490 500
NGPTFSSLEV NPDSENDFGN YNCSAVNSIG HESSEFILVQ ADTPSSPAIR
510 520 530 540 550
KVEPYSSTVM IVFDEPDATG GVPILKYKAE WRVVGQEKWH ARYYDAKEVS
560 570 580 590 600
AESIITVTGL KPETSYMVKL SAVNGKGLGD STPSQDFTTQ PVNISKPQGE
610 620 630 640 650
PSAPKLVGHL SEDGNSIKVD IIKQDDGGSP IRHYLVNYRA LNAVDWKPEM
660 670 680 690 700
RVPSNSHHVT LKTLEWNVDY EVIVVAENQQ GKSKQARLSF RTTAKPTATT
710 720
ANVGSCASFN VVPLLVCLVI AIVLC
Length:725
Mass (Da):80,232
Last modified:August 1, 1998 - v1
Checksum:iD476AA905DECDF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008163 mRNA. Translation: BAA25932.1.
PIRiJE0100.
UniGeneiXl.1054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008163 mRNA. Translation: BAA25932.1.
PIRiJE0100.
UniGeneiXl.1054.

3D structure databases

ProteinModelPortaliO73634.
SMRiO73634. Positions 20-302, 488-694.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO73634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052579.

Family and domain databases

Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR033019. Ncam1.
IPR009138. Neural_cell_adh.
[Graphical view]
PANTHERiPTHR10489:SF34. PTHR10489:SF34. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 3 hits.
[Graphical view]
PRINTSiPR01838. NCAMFAMILY.
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of ssd-form neural cell adhesion molecules (N-CAMs) as the major form in Xenopus heart."
    Kudo M., Takayama E., Tadakuma T., Shiokawa K.
    Biochem. Biophys. Res. Commun. 245:127-132(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: HeartImported.

Entry informationi

Entry nameiO73634_XENLA
AccessioniPrimary (citable) accession number: O73634
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.