Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium voltage-gated channel subfamily G member 2

Gene

KCNG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-GGA-1296072. Voltage gated Potassium channels.
R-GGA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Potassium channel cKv6.2
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:KCNG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217CytoplasmicSequence analysisAdd BLAST217
Transmembranei218 – 238Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini279 – 292CytoplasmicSequence analysisAdd BLAST14
Transmembranei293 – 313Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei336 – 356Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini357 – 369CytoplasmicSequence analysisAdd BLAST13
Transmembranei370 – 390Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei405 – 425Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei433 – 453Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini454 – 518CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540761 – 518Potassium voltage-gated channel subfamily G member 2Add BLAST518

Proteomic databases

PaxDbiO73606.

Expressioni

Gene expression databases

BgeeiENSGALG00000012652.

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020617.

Structurei

3D structure databases

ProteinModelPortaliO73606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 422Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiO73606.
KOiK04901.
OMAiSETTQCA.
OrthoDBiEOG091G05DD.
PhylomeDBiO73606.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

O73606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLTGNADR AFSSYSFNKL ENLCEVQTKK GFFYRKAKLL HPDEDLCYLA
60 70 80 90 100
RLDDRTRFVI INVGGIKYKV PWTTLENCPL TRLGKLKSCN NYDEIMNICD
110 120 130 140 150
DYDVSCNEFF FDRNPSAFRT IMTFLTAGKL RLLREMCALS FQEELVYWGI
160 170 180 190 200
EEDHLEWCCK KRLQQKEEEA AEARMYEGEM MFSETTQCAF QDNNWLSLCM
210 220 230 240 250
RNLRDMVENP HSGIPGKIFA CISISFVAIT AVSLCISTMP DVREEEDRGE
260 270 280 290 300
CSQKCYDIFV LETVCVAWFS FEFLLRSIQA ENKCAFLKTP LNIIDILAIL
310 320 330 340 350
PFYISLIVDM ASTKNSSKPG GGAGNKYLER VGLVLRFLRA LRILYVMRLA
360 370 380 390 400
RHSLGLQTLG LTVRRCTREF GLLLLFLCVA MALFSPLVYL AESELGAKQE
410 420 430 440 450
FTSIPTSYWW AVISMTTVGY GDMVPRSIPG QVVALSSILS GILLMAFPVT
460 470 480 490 500
SIFHTFSRSY SELKEQQQRA ASRQMHQLEE STKLAGGGSS QWITAASPPD
510
AAREDGRPEL DQEAKRSC
Length:518
Mass (Da):58,769
Last modified:August 1, 1998 - v1
Checksum:i5A1A57DC10AE6541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62139 mRNA. Translation: AAC06191.1.
RefSeqiNP_990370.1. NM_205039.1.
XP_015131321.1. XM_015275835.1.
XP_015131322.1. XM_015275836.1.
XP_015131323.1. XM_015275837.1.
XP_015131324.1. XM_015275838.1.
UniGeneiGga.2713.
Gga.50733.

Genome annotation databases

EnsembliENSGALT00000080410; ENSGALP00000057198; ENSGALG00000031754.
GeneIDi395902.
KEGGigga:395902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62139 mRNA. Translation: AAC06191.1.
RefSeqiNP_990370.1. NM_205039.1.
XP_015131321.1. XM_015275835.1.
XP_015131322.1. XM_015275836.1.
XP_015131323.1. XM_015275837.1.
XP_015131324.1. XM_015275838.1.
UniGeneiGga.2713.
Gga.50733.

3D structure databases

ProteinModelPortaliO73606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020617.

Proteomic databases

PaxDbiO73606.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000080410; ENSGALP00000057198; ENSGALG00000031754.
GeneIDi395902.
KEGGigga:395902.

Organism-specific databases

CTDi26251.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiO73606.
KOiK04901.
OMAiSETTQCA.
OrthoDBiEOG091G05DD.
PhylomeDBiO73606.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-GGA-1296072. Voltage gated Potassium channels.
R-GGA-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.

Miscellaneous databases

PROiO73606.

Gene expression databases

BgeeiENSGALG00000012652.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003969. K_chnl_volt-dep_Kv6.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01492. KV6CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG2_CHICK
AccessioniPrimary (citable) accession number: O73606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.