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Protein

Potassium voltage-gated channel subfamily G member 2

Gene

KCNG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-GGA-1296072 Voltage gated Potassium channels
R-GGA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 2
Alternative name(s):
Potassium channel cKv6.2
Voltage-gated potassium channel subunit Kv6.2
Gene namesi
Name:KCNG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 217CytoplasmicSequence analysisAdd BLAST217
Transmembranei218 – 238Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei258 – 278Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini279 – 292CytoplasmicSequence analysisAdd BLAST14
Transmembranei293 – 313Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei336 – 356Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini357 – 369CytoplasmicSequence analysisAdd BLAST13
Transmembranei370 – 390Helical; Name=Segment S5Sequence analysisAdd BLAST21
Intramembranei405 – 425Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei433 – 453Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini454 – 518CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540761 – 518Potassium voltage-gated channel subfamily G member 2Add BLAST518

Proteomic databases

PaxDbiO73606
PRIDEiO73606

Expressioni

Gene expression databases

BgeeiENSGALG00000012652

Interactioni

Subunit structurei

Heterodimer with KCNB1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020617

Structurei

3D structure databases

ProteinModelPortaliO73606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 422Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118981
HOGENOMiHOG000231014
HOVERGENiHBG100172
InParanoidiO73606
KOiK04901
OMAiIINVGGC
OrthoDBiEOG091G05DD
PhylomeDBiO73606
TreeFamiTF313103

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003969 K_chnl_volt-dep_Kv6
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01492 KV6CHANNEL
PR01491 KVCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

O73606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLTGNADR AFSSYSFNKL ENLCEVQTKK GFFYRKAKLL HPDEDLCYLA
60 70 80 90 100
RLDDRTRFVI INVGGIKYKV PWTTLENCPL TRLGKLKSCN NYDEIMNICD
110 120 130 140 150
DYDVSCNEFF FDRNPSAFRT IMTFLTAGKL RLLREMCALS FQEELVYWGI
160 170 180 190 200
EEDHLEWCCK KRLQQKEEEA AEARMYEGEM MFSETTQCAF QDNNWLSLCM
210 220 230 240 250
RNLRDMVENP HSGIPGKIFA CISISFVAIT AVSLCISTMP DVREEEDRGE
260 270 280 290 300
CSQKCYDIFV LETVCVAWFS FEFLLRSIQA ENKCAFLKTP LNIIDILAIL
310 320 330 340 350
PFYISLIVDM ASTKNSSKPG GGAGNKYLER VGLVLRFLRA LRILYVMRLA
360 370 380 390 400
RHSLGLQTLG LTVRRCTREF GLLLLFLCVA MALFSPLVYL AESELGAKQE
410 420 430 440 450
FTSIPTSYWW AVISMTTVGY GDMVPRSIPG QVVALSSILS GILLMAFPVT
460 470 480 490 500
SIFHTFSRSY SELKEQQQRA ASRQMHQLEE STKLAGGGSS QWITAASPPD
510
AAREDGRPEL DQEAKRSC
Length:518
Mass (Da):58,769
Last modified:August 1, 1998 - v1
Checksum:i5A1A57DC10AE6541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62139 mRNA Translation: AAC06191.1
RefSeqiNP_990370.1, NM_205039.1
XP_015131321.1, XM_015275835.1
XP_015131322.1, XM_015275836.1
XP_015131323.1, XM_015275837.1
XP_015131324.1, XM_015275838.1
UniGeneiGga.2713
Gga.50733

Genome annotation databases

EnsembliENSGALT00000080410; ENSGALP00000057198; ENSGALG00000031754
GeneIDi395902
KEGGigga:395902

Similar proteinsi

Entry informationi

Entry nameiKCNG2_CHICK
AccessioniPrimary (citable) accession number: O73606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health