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O73559 (CRMB_CWPXG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Soluble TNF receptor II
Alternative name(s):
Cytokine response-modifying protein B
Gene names
Name:CRMB1
ORF Names:D2L
AND
Name:CRMB2
ORF Names:I4R
OrganismCowpox virus (strain GRI-90 / Grishak) (CPV)
Taxonomic identifier265871 [NCBI]
Taxonomic lineageViruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus ›
Virus hostBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Function

Receptor for TNF-alpha and TNF-beta. May contribute to the modification of TNF-mediated antiviral processes. Ref.2

Subcellular location

Secreted.

Sequence similarities

Contains 2 TNFR-Cys repeats.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processevasion or tolerance by virus of host immune response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontumor necrosis factor-activated receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 351332Soluble TNF receptor II
PRO_0000034618

Regions

Repeat31 – 6737TNFR-Cys 1
Repeat69 – 11042TNFR-Cys 2

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...); by host Potential
Glycosylation1911N-linked (GlcNAc...); by host Potential
Glycosylation2501N-linked (GlcNAc...); by host Potential
Disulfide bond32 ↔ 43 By similarity
Disulfide bond44 ↔ 57 By similarity
Disulfide bond47 ↔ 67 By similarity
Disulfide bond70 ↔ 85 By similarity
Disulfide bond88 ↔ 102 By similarity
Disulfide bond92 ↔ 110 By similarity

Sequences

Sequence LengthMass (Da)Tools
O73559 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 57CAE73EF4E5D7C7

FASTA35138,254
        10         20         30         40         50         60 
MKSVLYSYIL FLSCIIINGR DIAPHAPSNG KCKDNEYNRH NLCCLSCPPG TYASRLCDSK 

        70         80         90        100        110        120 
TNTNTQCTPC GSGTFTSRNN HLPACLSCNG RCDSNQVETR SCNTTHNRIC ECAPGYYCLL 

       130        140        150        160        170        180 
KGSSGCKACV SQTKCGIGYG VSGHTSTGDV VCSPCGLGTY SHTVSSADKC EPVPSNTFNY 

       190        200        210        220        230        240 
IDVEINLYPV NDTSCTRTTT TGLSESISTS ELTITMNHKD CDPVFRDGYF SVLNKVATSG 

       250        260        270        280        290        300 
FFTGENRYQN ISKVCTLNFE IKCNNKDSSS KQLTKTKNDD GIMPHSETVT LVGDCLSSVD 

       310        320        330        340        350 
IYILYSNTNT QDYETDTISY HVGNVLDVDS HMPGSCDIHK LITNSKPTRF L

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References

[1]"The genomic sequence analysis of the left and right species-specific terminal region of a cowpox virus strain reveals unique sequences and a cluster of intact ORFs for immunomodulatory and host range proteins."
Shchelkunov S.N., Safronov P.F., Totmenin A.V., Petrov N.A., Ryazankina O.I., Gutorov V.V., Kotwal G.J.
Virology 243:432-460(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GRI-90 / Grishak.
[2]"Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor."
Hu F.Q., Smith C.A., Pickup D.J.
Virology 204:343-356(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: Brighton red.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X94355 Genomic DNA. Translation: CAA64087.2.
X94355 Genomic DNA. Translation: CAD90756.1.

3D structure databases

ProteinModelPortalO73559.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR010806. Poxvirus_TNF-rcpt-II_C.
IPR011172. Poxvirus_TNF_rcpt-II.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF07190. DUF1406. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFPIRSF001790. TNF_C22L. 1 hit.
SMARTSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRMB_CWPXG
AccessionPrimary (citable) accession number: O73559
Secondary accession number(s): P87602
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 1, 1998
Last modified: April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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