O72908 (MCES_FOWPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
mRNA-capping enzyme small subunit

Alternative name(s):
mRNA (guanine-N(7)-)-methyltransferase
EC=2.1.1.56
mRNA cap methyltransferase

Gene names

Ordered Locus Names:	FPV051
ORF Names:	FP-D12, FPD12

Organism

Fowlpox virus (strain NVSL) (FPV)

Taxonomic identifier

928301 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Avipoxvirus

Virus host

Vertebrata [TaxID: 7742]

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Catalyzes the last reaction in the mRNA cap formation pathway.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subunit structure	Heterodimer of a large and a small subunit.
Subcellular location	Virion Probable. Note: All the enzymes and other proteins required to synthesize early mRNAs are packaged within the virion core along with the DNA genome.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Virion
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	mRNA-capping enzyme small subunit		PRO_0000210139

Sequences

	Sequence		Length	Mass (Da)
	O72908 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: ADCEFC32AA71B131	FASTA	289	33,867
	10 20 30 40 50 60 MNTDRITAFI KNGISARMPF YDTLPDMDLV FGKNHLPSLE YGANYFLQLS KINDINRLST 70 80 90 100 110 120 EMLSLYTHDL NKESDISKLF EPYNIKTIKS YGRSIQADAV VVDLRPSNSL YKNEHPYYKS 130 140 150 160 170 180 NNYLKENNLY ICDYTMITFE IYRPIFELST EKTCIIKVPT LFGKTIVNAV RVYCSLFRYV 190 200 210 220 230 240 KLYKLSADSW LKDSAIIVCQ QPHAANINKF ITYIRKVTKS QTWLDSNNVN FILIHDSVER 250 260 270 280 VFIEKFLSFS YKIYESLYYV HSLLYSSMTS DLQSLDNEYQ KKLIKLLRG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Skinner M.A. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FP-9 / Isolate HP-440.
[2]	"Analysis of the fowlpox virus genome region corresponding to the vaccinia virus D6 to A1 region: location of, and variation in, non-essential genes in poxviruses." Binns M.M., Britton B.S., Mason C., Boursnell M.E.G. J. Gen. Virol. 71:2873-2881(1990) [PubMed: 2177083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genome of fowlpox virus." Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L. J. Virol. 74:3815-3831(2000) [PubMed: 10729156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ005163 Genomic DNA. Translation: CAA06402.1. AF198100 Genomic DNA. Translation: AAF44395.1.
PIR	S42252.
RefSeq	NP_039014.1. NC_002188.1.
3D structure databases
ProteinModelPortal	O72908.
SMR	O72908. Positions 4-287.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1486599.
Phylogenomic databases
ProtClustDB	CLSP2509800.
Family and domain databases
InterPro	IPR005009. Poxvirus_mRNA-cap_ssu. [Graphical view]
Pfam	PF03341. Pox_mRNA-cap. 1 hit. [Graphical view]
ProDom	PD009934. Pox_mRNA-cap. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MCES_FOWPN

Accession

Primary (citable) accession number: O72908

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program