ID   NTP1_FOWPV              Reviewed;         637 AA.
AC   O72907;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Nucleoside triphosphatase I;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase I;
DE            Short=NPH I;
GN   Name=NPH1; OrderedLocusNames=FPV052; ORFNames=FP-D11, FPD11;
OS   Fowlpox virus (FPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Avipoxvirus.
OX   NCBI_TaxID=10261;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FP-9 / Isolate HP-440;
RA   Skinner M.A.;
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91108382; PubMed=2177083;
RA   Binns M.M., Britton B.S., Mason C., Boursnell M.E.G.;
RT   "Analysis of the fowlpox virus genome region corresponding to the
RT   vaccinia virus D6 to A1 region: location of, and variation in, non-
RT   essential genes in poxviruses.";
RL   J. Gen. Virol. 71:2873-2881(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20193820; PubMed=10729156;
RX   DOI=10.1128/JVI.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Serves two roles in transcription; it acts in concert
CC       with viral termination factor/capping enzyme to catalyze release
CC       of UUUUUNU-containing nascent RNA from the elongation complex, and
CC       it acts by itself as a polymerase elongation factor to facilitate
CC       readthrough of intrinsic pause sites (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SIMILARITY: Belongs to the helicase family. NPH I subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR   EMBL; AJ005163; CAA06401.1; -; Genomic_DNA.
DR   EMBL; AF198100; AAF44396.1; -; Genomic_DNA.
DR   PIR; S42251; S42251.
DR   RefSeq; NP_039015.1; -.
DR   GeneID; 1486600; -.
DR   BRENDA; 3.6.1.15; 288568.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_N.
DR   InterPro; IPR001650; DNA/RNA_helicase_C.
DR   InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd.
DR   InterPro; IPR013676; NPHI_C.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08469; NPHI_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Hydrolase; Nucleotide-binding; Transcription.
FT   CHAIN         1    637       Nucleoside triphosphatase I.
FT                                /FTId=PRO_0000099094.
FT   DOMAIN       43    205       Helicase ATP-binding.
FT   DOMAIN      358    537       Helicase C-terminal.
FT   NP_BIND      56     63       ATP (By similarity).
FT   MOTIF       142    145       DEXH box.
SQ   SEQUENCE   637 AA;  73774 MW;  9F838D2E0519F0D8 CRC64;
     MNTYAAYIDY ALKKLDTFPV DMTGGNDNTV LLKDYQLFVA KVFLGLNSMN SILLFQETGV
     GKTITTVYML KNLKKIYSEW TIIILVKKAL IDDPWTHTIL DYAPEVMKDC IIMNYDDQNF
     HNKFFTNIKS INVKSRIFII IDECHNFISK SLTKEDNKKR NTKLVYNYIA KNLMQKNNKL
     ICLSATPIVN DVREFQMLVN LLRPGILTPD KSLFYNKKLI DEKEIISKLG CICSYIVNNE
     ASIFEDVENT TLFAKKTVHI KHVFMSKKQE ELYLKARYLE RKLGISVFKI YQRMASTFVF
     DDIPDKKKLT EEEYEKFVDS LSIDFKNTLY GKKISKQSLD ILSAGGTIND IKDVKDIELY
     NYLYEHSCKF TFVCVSIIQS KGKCLVFEPF IRSSGIEILL QYFNVFGITY IEFSSRTKDI
     RSKSVSDFNK VDNTDGEITK VCVFSQSGNE GISFLSINDI FILDMTWNEA SLKQIIGRAI
     RLNSHVNNPP ERRYVNVYFV VAKLSSGRSS VDDILLDIIQ SKSKEFSQLY KVFKHSSIEW
     IYSNYTDFQT VDDEKGFKKL ISRNIILDEN TITNKKKLTM GENIWYSFSS SLVSIHRGFK
     SMDNKIYDSE GFFITVLPDK PTIKIYEGKL IYILTVR
//