Reviewed, UniProtKB/Swiss-Prot O72907 (NTP1_FOWPV)

Names and origin

Protein names

Recommended name:
    Nucleoside triphosphatase I
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase I
      Short name=NPH I

Gene names

Name:	NPH1
Ordered Locus Names:	FPV052
ORF Names:	FP-D11, FPD11

Organism

Fowlpox virus (FPV)

Taxonomic identifier

10261 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Avipoxvirus

Virus host

Vertebrata [TaxID: 7742]

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serves two roles in transcription; it acts in concert with viral termination factor/capping enzyme to catalyze release of UUUUUNU-containing nascent RNA from the elongation complex, and it acts by itself as a polymerase elongation factor to facilitate readthrough of intrinsic pause sites By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate.
Sequence similarities	Belongs to the helicase family. NPH I subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.

Ontologies

Keywords
Biological process	Transcription
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	Nucleoside triphosphatase I		PRO_0000099094
Regions
	Domain	43 – 205	163	Helicase ATP-binding
	Domain	358 – 537	180	Helicase C-terminal
	Nucleotide binding	56 – 63	8	ATP By similarity
	Motif	142 – 145	4	DEXH box

Sequences

	Sequence		Length	Mass (Da)
	O72907-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 9F838D2E0519F0D8	FASTA	637	73,774
	10 20 30 40 50 60 MNTYAAYIDY ALKKLDTFPV DMTGGNDNTV LLKDYQLFVA KVFLGLNSMN SILLFQETGV 70 80 90 100 110 120 GKTITTVYML KNLKKIYSEW TIIILVKKAL IDDPWTHTIL DYAPEVMKDC IIMNYDDQNF 130 140 150 160 170 180 HNKFFTNIKS INVKSRIFII IDECHNFISK SLTKEDNKKR NTKLVYNYIA KNLMQKNNKL 190 200 210 220 230 240 ICLSATPIVN DVREFQMLVN LLRPGILTPD KSLFYNKKLI DEKEIISKLG CICSYIVNNE 250 260 270 280 290 300 ASIFEDVENT TLFAKKTVHI KHVFMSKKQE ELYLKARYLE RKLGISVFKI YQRMASTFVF 310 320 330 340 350 360 DDIPDKKKLT EEEYEKFVDS LSIDFKNTLY GKKISKQSLD ILSAGGTIND IKDVKDIELY 370 380 390 400 410 420 NYLYEHSCKF TFVCVSIIQS KGKCLVFEPF IRSSGIEILL QYFNVFGITY IEFSSRTKDI 430 440 450 460 470 480 RSKSVSDFNK VDNTDGEITK VCVFSQSGNE GISFLSINDI FILDMTWNEA SLKQIIGRAI 490 500 510 520 530 540 RLNSHVNNPP ERRYVNVYFV VAKLSSGRSS VDDILLDIIQ SKSKEFSQLY KVFKHSSIEW 550 560 570 580 590 600 IYSNYTDFQT VDDEKGFKKL ISRNIILDEN TITNKKKLTM GENIWYSFSS SLVSIHRGFK 610 620 630 SMDNKIYDSE GFFITVLPDK PTIKIYEGKL IYILTVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Skinner M.A. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: FP-9 / Isolate HP-440.
[2]	"Analysis of the fowlpox virus genome region corresponding to the vaccinia virus D6 to A1 region: location of, and variation in, non-essential genes in poxviruses." Binns M.M., Britton B.S., Mason C., Boursnell M.E.G. J. Gen. Virol. 71:2873-2881(1990) [PubMed: 2177083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The genome of fowlpox virus." Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L. J. Virol. 74:3815-3831(2000) [PubMed: 10729156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ005163 Genomic DNA. Translation: CAA06401.1. AF198100 Genomic DNA. Translation: AAF44396.1.
PIR	S42251.
RefSeq	NP_039015.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1486600.
Enzyme and pathway databases
BRENDA	3.6.1.15. 288568.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR013676. NPHI_C. IPR000330. SNF2_N. [Graphical view]
Pfam	PF00271. Helicase_C. 1 hit. PF08469. NPHI_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTP1_FOWPV

Accession

Primary (citable) accession number: O72907

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)