ID   NTP2_FOWPV              Reviewed;         682 AA.
AC   O72904;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Nucleoside triphosphatase II;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase II;
DE            Short=NPH II;
GN   Name=NPH2; OrderedLocusNames=FPV082; ORFNames=FPI8R;
OS   Fowlpox virus (FPV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Avipoxvirus.
OX   NCBI_TaxID=10261;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FP-9 / Isolate HP-440;
RX   MEDLINE=92410746; PubMed=1326827; DOI=10.1016/0168-1702(92)90004-S;
RA   Binns M.M., Boursnell M.E.G., Skinner M.A.;
RT   "Gene translocations in poxviruses: the fowlpox virus thymidine kinase
RT   gene is flanked by 15 bp direct repeats and occupies the locus which
RT   in vaccinia virus is occupied by the ribonucleotide reductase large
RT   subunit gene.";
RL   Virus Res. 24:161-172(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=20193820; PubMed=10729156;
RX   DOI=10.1128/JVI.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Essential for viral replication. Plays an important role
CC       during transcription of early mRNAs, presumably by preventing R-
CC       loop formation behind the elongating RNA polymerase. Acts as NTP-
CC       dependent helicase that catalyzes unidirectional unwinding of
CC       3'tailed duplex RNAs. Might also play a role in the export of
CC       newly synthesized mRNA chains out of the core into the cytoplasm.
CC       Required for propagation of viral particles (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- WEB RESOURCE: Name=The DExH/D protein family database;
CC       Note=Poxviridae DExH proteins;
CC       URL="http://www.dexhd.org/viral_pox.htm";
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DR   EMBL; AJ223385; CAA11299.1; -; Genomic_DNA.
DR   EMBL; AF198100; AAF44426.1; -; Genomic_DNA.
DR   PIR; G48563; G48563.
DR   RefSeq; NP_039045.1; -.
DR   GeneID; 1486630; -.
DR   BRENDA; 3.6.1.15; 288568.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_N.
DR   InterPro; IPR001650; DNA/RNA_helicase_C.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR014021; Helicase_SF1/SF2_ATP-bd.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; FALSE_NEG.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Transcription.
FT   CHAIN         1    682       Nucleoside triphosphatase II.
FT                                /FTId=PRO_0000055187.
FT   DOMAIN      181    354       Helicase ATP-binding.
FT   DOMAIN      386    551       Helicase C-terminal.
FT   NP_BIND     194    201       ATP (By similarity).
FT   MOTIF       303    306       DEXH box.
SQ   SEQUENCE   682 AA;  79808 MW;  F394E69FD9745652 CRC64;
     MTTNDLFSIY AFSNMYDIFP RKYSQKELEE YHRKNPLFFS YTIFPVIKHR WSKAYICFQN
     NVYMLNIELD TSKPYDRVPI QHLIDIRPIS TDIKKEIYKI SDKTFITFEC YSYLKCKGYN
     SIYDITLDDK RGLLSAGNIL SIFSSNKQMP EKSSIGILKN PKPFTVIKFK SLSLITQLQI
     FELLRKRKQI VVTGSTGIGK TSQLPKVIMW YNYLFGGWDN LDRVRFDYIS RPIVLSLPRV
     ALVKSNGINF LQSLGFSDFE GSPVELRYGG KTEHTTRQHD GIVLSTNKLT SYSLSNYNII
     IVDEIHEHDR IADIIISVLR KNIDTIHSLV LMSATLEDDR DRLQEFLPDV EFYHIEGPVL
     YSIKEIYVKN KYSYDSKAYT EEEKKNISTT LNWCRPRNGM CGILFLASVS QCISYKKYLE
     KSNSDMDFII IHGKIPDITE VLNAVQRPGR ERPCILVSTP YLESSITIRT ATHVYDTGRV
     YVPKPFGGDQ LFISKSMMTQ RKGRVGRVSK GIYVYFYDMC LLKPIKSIDH EFLYEYIVYA
     KKFKLSLPND LLVIPSDKDM LKKSEEYIKS FNISFDRLFE IYVNYFVNMV EYVKIYNKGG
     KKAENLDMFE RNDILTGETL KDIKNLQLLV KINTTTRRKK MYCYKGEILF GPYMNTVIRL
     SSKQLYRNYV YMLTERSFTL YR
//