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Protein

RNA helicase NPH-II

Gene

NPH2

Organism
Fowlpox virus (strain NVSL) (FPV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 201ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processTranscription
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA helicase NPH-II (EC:3.6.4.13)
Alternative name(s):
Nucleoside triphosphatase II
Short name:
NTPase II
Nucleoside triphosphate phosphohydrolase II
Short name:
NPH II
Gene namesi
Name:NPH2
Ordered Locus Names:FPV082
ORF Names:FPI8R
OrganismiFowlpox virus (strain NVSL) (FPV)
Taxonomic identifieri928301 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeAvipoxvirus
Virus hostiVertebrata [TaxID: 7742]
Proteomesi
  • UP000008597 Componenti: Genome

Subcellular locationi

  • Virion

  • Note: Localizes to the virion core.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551871 – 682RNA helicase NPH-IIAdd BLAST682

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliO72904.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 354Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST174
Domaini386 – 551Helicase C-terminalPROSITE-ProRule annotationAdd BLAST166

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi303 – 306DEXH box4

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000039.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR021892. NPH-II.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF12011. NPH-II. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

O72904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNDLFSIY AFSNMYDIFP RKYSQKELEE YHRKNPLFFS YTIFPVIKHR
60 70 80 90 100
WSKAYICFQN NVYMLNIELD TSKPYDRVPI QHLIDIRPIS TDIKKEIYKI
110 120 130 140 150
SDKTFITFEC YSYLKCKGYN SIYDITLDDK RGLLSAGNIL SIFSSNKQMP
160 170 180 190 200
EKSSIGILKN PKPFTVIKFK SLSLITQLQI FELLRKRKQI VVTGSTGIGK
210 220 230 240 250
TSQLPKVIMW YNYLFGGWDN LDRVRFDYIS RPIVLSLPRV ALVKSNGINF
260 270 280 290 300
LQSLGFSDFE GSPVELRYGG KTEHTTRQHD GIVLSTNKLT SYSLSNYNII
310 320 330 340 350
IVDEIHEHDR IADIIISVLR KNIDTIHSLV LMSATLEDDR DRLQEFLPDV
360 370 380 390 400
EFYHIEGPVL YSIKEIYVKN KYSYDSKAYT EEEKKNISTT LNWCRPRNGM
410 420 430 440 450
CGILFLASVS QCISYKKYLE KSNSDMDFII IHGKIPDITE VLNAVQRPGR
460 470 480 490 500
ERPCILVSTP YLESSITIRT ATHVYDTGRV YVPKPFGGDQ LFISKSMMTQ
510 520 530 540 550
RKGRVGRVSK GIYVYFYDMC LLKPIKSIDH EFLYEYIVYA KKFKLSLPND
560 570 580 590 600
LLVIPSDKDM LKKSEEYIKS FNISFDRLFE IYVNYFVNMV EYVKIYNKGG
610 620 630 640 650
KKAENLDMFE RNDILTGETL KDIKNLQLLV KINTTTRRKK MYCYKGEILF
660 670 680
GPYMNTVIRL SSKQLYRNYV YMLTERSFTL YR
Length:682
Mass (Da):79,808
Last modified:August 1, 1998 - v1
Checksum:iF394E69FD9745652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223385 Genomic DNA. Translation: CAA11299.1.
AF198100 Genomic DNA. Translation: AAF44426.1.
PIRiG48563.
RefSeqiNP_039045.1. NC_002188.1.

Genome annotation databases

GeneIDi1486630.
KEGGivg:1486630.

Similar proteinsi

Entry informationi

Entry nameiNPH2_FOWPN
AccessioniPrimary (citable) accession number: O72904
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 1, 1998
Last modified: April 12, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families