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Protein

Kelch repeat and BTB domain-containing protein 2

Gene

KBTB2

Organism
Cowpox virus (strain GRI-90 / Grishak) (CPV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Modulation of host E3 ubiquitin ligases by virus, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 2
Gene namesi
Name:KBTB2
Ordered Locus Names:B19R
OrganismiCowpox virus (strain GRI-90 / Grishak) (CPV)
Taxonomic identifieri265871 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Kelch repeat and BTB domain-containing protein 2PRO_0000396132Add
BLAST

Interactioni

Subunit structurei

Interacts (via BTB domain) with host CUL3.By similarity

Structurei

3D structure databases

ProteinModelPortaliO72756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9570BTBPROSITE-ProRule annotationAdd
BLAST
Domaini133 – 22391BACKAdd
BLAST
Repeati305 – 35248Kelch 1Add
BLAST
Repeati353 – 39947Kelch 2Add
BLAST
Repeati401 – 46464Kelch 3Add
BLAST

Domaini

The BTB domain is responsible for the interaction with CUL3 while the Kelch repeat domains supposely serve to recruit the cellular substrates.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 3 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O72756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIENDIRNR RIIRNISNLL DDDILCDVII TIGDGEEIKA HKTILAAGST
60 70 80 90 100
YFKTMFTTPM IARDLVTRVN LQMFDKDAVK NIVQYLYNRH ISSMNVIDVL
110 120 130 140 150
KCADYLLIDD LVADCESYIK DYINHDTCIY MYHKLYEMVH IPIVKYIKRM
160 170 180 190 200
LMSNIPTLIT TDAFKKTVFE ILFDIISTND NVYLYREGYK VTILLKWLEY
210 220 230 240 250
NHITEEQLLC ILSCIDIQNL DKKSRLLLYS NKTINMYPSC IQFLLDNKQN
260 270 280 290 300
RNIIPRQLCL ACHDTNYNVC NPCILVYNIN TMEYSVISTI PNHIINYASA
310 320 330 340 350
IVDNEIIIAG GYNFNNPSLN KVYKINIENK IHVELPPMIK NRCRFSLAVI
360 370 380 390 400
DDTIYAIGGQ NGTNVERTIE CYTLGDDKWK MLPDMPIALS SYGMCVLDQY
410 420 430 440 450
IYIIGGRTQH IDYTSVHTVN SIDMEEDTNI SNKVIRYDTV NNIWETLPNF
460 470 480 490 500
WTGTINPGVV SHKDDIYVVC DIKDEKNVKT CIFRYNTNTY NGWELVTTTE
510 520 530 540 550
SRLSALHTIL HDNTIMMLHC YESYMLQDTF NVYTREWNHM CHQHSNSYIM

HNILPIY
Length:557
Mass (Da):64,913
Last modified:August 1, 1998 - v1
Checksum:iFC7CD74C0B7553D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94355 Genomic DNA. Translation: CAD90745.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94355 Genomic DNA. Translation: CAD90745.1.

3D structure databases

ProteinModelPortaliO72756.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00612. Kelch. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure-function and organization of cowpox virus strain GRI-90 complete genome."
    Shchelkunov S.N., Safronov P.F., Totmenin A.V., Miheev M.V., Ryazankina O.I., Petrov N.A., Gutorov V.V., Kotwal G.J., Sandakhchiev L.S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKBTB2_CWPXG
AccessioniPrimary (citable) accession number: O72756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 1, 1998
Last modified: January 20, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.