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Protein

Kelch repeat and BTB domain-containing protein 1

Gene

KBTB1

Organism
Cowpox virus (strain GRI-90 / Grishak) (CPV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Modulation of host E3 ubiquitin ligases by virus, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 1
Gene namesi
Name:KBTB1
Ordered Locus Names:A57R
OrganismiCowpox virus (strain GRI-90 / Grishak) (CPV)
Taxonomic identifieri265871 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Kelch repeat and BTB domain-containing protein 1PRO_0000396136Add
BLAST

Interactioni

Subunit structurei

Interacts (via BTB domain) with host CUL3.By similarity

Structurei

3D structure databases

ProteinModelPortaliO72736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 8868BTBPROSITE-ProRule annotationAdd
BLAST
Domaini123 – 21997BACKAdd
BLAST
Repeati252 – 29746Kelch 1Add
BLAST
Repeati298 – 34649Kelch 2Add
BLAST
Repeati347 – 39549Kelch 3Add
BLAST
Repeati397 – 44145Kelch 4Add
BLAST
Repeati442 – 49251Kelch 5Add
BLAST
Repeati494 – 53946Kelch 6Add
BLAST

Domaini

The BTB domain is responsible for the interaction with CUL3 while the Kelch repeat domains supposely serve to recruit the cellular substrates.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
IPR024182. Vaccinia_A55R.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF003716. VAC_F3L. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O72736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHRLILS GASEYFSILF
60 70 80 90 100
SNNFIDSNEY EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF
110 120 130 140 150
LQIGSAITEC EKYILKNLCS RNCIDFYIYA DKYNNKKIES ASFNTILRNI
160 170 180 190 200
LRLINDENFK YLTEESMIKI LSDDMLNIKN EDFAPLILIK WLESTQQSCT
210 220 230 240 250
VELLRCLRIS LLSPQVIKSL YSHQLVSSIY ECITFLNNIA FLDESFPRYH
260 270 280 290 300
SIELISIGIS NSHDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
310 320 330 340 350
MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC
360 370 380 390 400
IGGIRDQDSS LTSSIDRWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVI
410 420 430 440 450
GGIVKGDTCT DALESLSEDG WMKHQRLPIK MSNMSTIVHD GKIYISGGYN
460 470 480 490 500
NSSVVNVISN LVLSYNPIYD EWTKLSSLNI PRINPALWSA HNKLYVGGGI
510 520 530 540 550
SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK HKYPLEKTQY
560
TNDFLKYLES FIGS
Length:564
Mass (Da):64,826
Last modified:August 1, 1998 - v1
Checksum:iEF268497F8DC6AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94355 Genomic DNA. Translation: CAD90724.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94355 Genomic DNA. Translation: CAD90724.1.

3D structure databases

ProteinModelPortaliO72736.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.120.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
IPR024182. Vaccinia_A55R.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 2 hits.
[Graphical view]
PIRSFiPIRSF003716. VAC_F3L. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 5 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBTB1_CWPXG
AccessioniPrimary (citable) accession number: O72736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 1, 1998
Last modified: January 20, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.