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Protein

Kelch repeat and BTB domain-containing protein 1

Gene

KBTB1

Organism
Cowpox virus (strain GRI-90 / Grishak) (CPV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable substrate-specific adapter of CUL3-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host E3 ubiquitin ligases by virus, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 1
Gene namesi
Name:KBTB1
Ordered Locus Names:A57R
OrganismiCowpox virus (strain GRI-90 / Grishak) (CPV)
Taxonomic identifieri265871 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]
Homo sapiens (Human) [TaxID: 9606]
Loxodonta africana (African elephant) [TaxID: 9785]
Microtus agrestis (Short-tailed field vole) [TaxID: 29092]
Mus musculus (Mouse) [TaxID: 10090]
Myodes glareolus (Bank vole) (Clethrionomys glareolus) [TaxID: 447135]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003961361 – 564Kelch repeat and BTB domain-containing protein 1Add BLAST564

Proteomic databases

PRIDEiO72736

Interactioni

Subunit structurei

Interacts (via BTB domain) with host CUL3.By similarity

Structurei

3D structure databases

ProteinModelPortaliO72736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 88BTBPROSITE-ProRule annotationAdd BLAST68
Domaini123 – 219BACKAdd BLAST97
Repeati252 – 297Kelch 1Add BLAST46
Repeati298 – 346Kelch 2Add BLAST49
Repeati347 – 395Kelch 3Add BLAST49
Repeati397 – 441Kelch 4Add BLAST45
Repeati442 – 492Kelch 5Add BLAST51
Repeati494 – 539Kelch 6Add BLAST46

Domaini

The BTB domain is responsible for the interaction with CUL3 while the Kelch repeat domains supposely serve to recruit the cellular substrates.By similarity

Keywords - Domaini

Kelch repeat, Repeat

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
IPR024182 Vaccinia_A55R
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
PIRSFiPIRSF003716 VAC_F3L, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

O72736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSSELIAV INGFRNSGRF CDINIVINDE RINAHRLILS GASEYFSILF
60 70 80 90 100
SNNFIDSNEY EVNLSHLDYQ SVNDLIDYIY GIPLSLTNDN VKYILSTADF
110 120 130 140 150
LQIGSAITEC EKYILKNLCS RNCIDFYIYA DKYNNKKIES ASFNTILRNI
160 170 180 190 200
LRLINDENFK YLTEESMIKI LSDDMLNIKN EDFAPLILIK WLESTQQSCT
210 220 230 240 250
VELLRCLRIS LLSPQVIKSL YSHQLVSSIY ECITFLNNIA FLDESFPRYH
260 270 280 290 300
SIELISIGIS NSHDKISINC YNHKKNTWEM ISSRRYRCSF AVAVLDNIIY
310 320 330 340 350
MMGGYDQSPY RSSKVIAYNT CTNSWIYDIP ELKYPRSNCG GLADDEYIYC
360 370 380 390 400
IGGIRDQDSS LTSSIDRWKP SKPYWQKYAK MREPKCDMGV AMLNGLIYVI
410 420 430 440 450
GGIVKGDTCT DALESLSEDG WMKHQRLPIK MSNMSTIVHD GKIYISGGYN
460 470 480 490 500
NSSVVNVISN LVLSYNPIYD EWTKLSSLNI PRINPALWSA HNKLYVGGGI
510 520 530 540 550
SDDVRTNTSE TYDKEKDCWT LDNGHVLPRN YIMYKCEPIK HKYPLEKTQY
560
TNDFLKYLES FIGS
Length:564
Mass (Da):64,826
Last modified:August 1, 1998 - v1
Checksum:iEF268497F8DC6AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94355 Genomic DNA Translation: CAD90724.1

Similar proteinsi

Entry informationi

Entry nameiKBTB1_CWPXG
AccessioniPrimary (citable) accession number: O72736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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