SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O72142

- NCAP_EBOZ5

UniProt

O72142 - NCAP_EBOZ5

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Nucleoprotein
Gene
NP
Organism
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. viral RNA genome packaging Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding, Viral nucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
Protein N
Gene namesi
Name:NP
OrganismiZaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
Taxonomic identifieri128951 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
ProteomesiUP000007208: Genome

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. helical viral capsid Source: UniProtKB-KW
  2. host cell cytoplasm Source: UniProtKB-SubCell
  3. ribonucleoprotein complex Source: UniProtKB-KW
  4. viral nucleocapsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 739739Nucleoprotein
PRO_0000222172Add
BLAST

Post-translational modificationi

Phosphorylated and O-glycosylated by host By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili334 – 36330 Reviewed prediction
Add
BLAST

Domaini

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR008609. Ebola_NP.
[Graphical view]
PfamiPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFiPIRSF003900. N_FiloV. 1 hit.

Sequencei

Sequence statusi: Complete.

O72142-1 [UniParc]FASTAAdd to Basket

« Hide

MDSRPQKVWM TPSLTESDMD YHKILTAGLS VQQGIVRQRV IPVYQVNNLE    50
EICQLIIQAF EAGVDFQESA DSFLLMLCLH HAYQGDYKLF LESGAVKYLE 100
GHGFRFEVKK RDGVKRLEEL LPAVSSGKNI KRTLAAMPEE ETTEANAGQF 150
LSFASLFLPK LVVGEKACLE KVQRQIQVHA EQGLIQYPTA WQSVGHMMVI 200
FRLMRTNFLI KFLLIHQGMH MVAGHDANDA VISNSVAQAR FSGLLIVKTV 250
LDHILQKTER GVRLHPLART AKVKNEVNSF KAALSSLAKH GEYAPFARLL 300
NLSGVNNLEH GLFPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA 350
EKQLQQYAES RELDHLGLDD QEKKILMNFH QKKNEISFQQ TNAMVTLRKE 400
RLAKLTEAIT AASLPKTSGH YDDDDDIPFP GPINDDDNPG HQDDDPTDSQ 450
DTTIPDVVVD PDDGSYGEYQ SYSENGMNAP DDLVLFDLDE DDEDTKPVPN 500
RSTKGGQQKN SQKGQHTEGR QTQSRPTQNV PGPHRTIHHA SAPLTDNDRR 550
NEPSGSTSPR MLTPINEEAD PLDDADDETS SLPPLESDDE EQDRDGTSNR 600
TPTVAPPAPV YRDHSEKREL PQDEQQDQDH TQEARNQDSD NTQPEHSFEE 650
MYRHILRSQG PFDAVLYYHM MKDEPVVFST SDGKEYTYPD SLEEEYPPWL 700
TEKEAMNEEN RFVTLDGQQF YWPVMNHKNK FMAILQHHQ 739
Length:739
Mass (Da):83,317
Last modified:August 1, 1998 - v1
Checksum:i74D9437293AFF443
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054908 mRNA. Translation: AAC09342.1.
AY354458 Genomic RNA. Translation: AAQ55045.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF054908 mRNA. Translation: AAC09342.1 .
AY354458 Genomic RNA. Translation: AAQ55045.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008609. Ebola_NP.
[Graphical view ]
Pfami PF05505. Ebola_NP. 1 hit.
[Graphical view ]
PIRSFi PIRSF003900. N_FiloV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge."
    Vanderzanden L., Bray M., Fuller D., Roberts T., Custer D., Spik K., Jahrling P., Huggins J., Schmaljohn A., Schmaljohn C.
    Virology 246:134-144(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiNCAP_EBOZ5
AccessioniPrimary (citable) accession number: O72142
Secondary accession number(s): Q6V1R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi