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O72142 (NCAP_EBOZ5) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name=Protein N
Gene names
Name:NP
OrganismZaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus) [Complete proteome]
Taxonomic identifier128951 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
Virus hostEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
Homo sapiens (Human) [TaxID: 9606]
Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]

Protein attributes

Sequence length739 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases By similarity.

Subunit structure

Homooligomer. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. Interacts with VP35 and VP30 to form the nucleocapsid. Also interacts with VP24 and VP40 By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Domain

This protein can be divided into a hydrophobic N-terminal half, and a hydrophilic and highly acidic C-terminal half By similarity.

Post-translational modification

Phosphorylated and O-glycosylated by host By similarity.

Sequence similarities

Belongs to the filoviruses nucleoprotein family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 739739Nucleoprotein
PRO_0000222172

Regions

Coiled coil334 – 36330 Potential

Sequences

Sequence LengthMass (Da)Tools
O72142 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 74D9437293AFF443

FASTA73983,317
        10         20         30         40         50         60 
MDSRPQKVWM TPSLTESDMD YHKILTAGLS VQQGIVRQRV IPVYQVNNLE EICQLIIQAF 

        70         80         90        100        110        120 
EAGVDFQESA DSFLLMLCLH HAYQGDYKLF LESGAVKYLE GHGFRFEVKK RDGVKRLEEL 

       130        140        150        160        170        180 
LPAVSSGKNI KRTLAAMPEE ETTEANAGQF LSFASLFLPK LVVGEKACLE KVQRQIQVHA 

       190        200        210        220        230        240 
EQGLIQYPTA WQSVGHMMVI FRLMRTNFLI KFLLIHQGMH MVAGHDANDA VISNSVAQAR 

       250        260        270        280        290        300 
FSGLLIVKTV LDHILQKTER GVRLHPLART AKVKNEVNSF KAALSSLAKH GEYAPFARLL 

       310        320        330        340        350        360 
NLSGVNNLEH GLFPQLSAIA LGVATAHGST LAGVNVGEQY QQLREAATEA EKQLQQYAES 

       370        380        390        400        410        420 
RELDHLGLDD QEKKILMNFH QKKNEISFQQ TNAMVTLRKE RLAKLTEAIT AASLPKTSGH 

       430        440        450        460        470        480 
YDDDDDIPFP GPINDDDNPG HQDDDPTDSQ DTTIPDVVVD PDDGSYGEYQ SYSENGMNAP 

       490        500        510        520        530        540 
DDLVLFDLDE DDEDTKPVPN RSTKGGQQKN SQKGQHTEGR QTQSRPTQNV PGPHRTIHHA 

       550        560        570        580        590        600 
SAPLTDNDRR NEPSGSTSPR MLTPINEEAD PLDDADDETS SLPPLESDDE EQDRDGTSNR 

       610        620        630        640        650        660 
TPTVAPPAPV YRDHSEKREL PQDEQQDQDH TQEARNQDSD NTQPEHSFEE MYRHILRSQG 

       670        680        690        700        710        720 
PFDAVLYYHM MKDEPVVFST SDGKEYTYPD SLEEEYPPWL TEKEAMNEEN RFVTLDGQQF 

       730 
YWPVMNHKNK FMAILQHHQ 

« Hide

References

[1]"DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge."
Vanderzanden L., Bray M., Fuller D., Roberts T., Custer D., Spik K., Jahrling P., Huggins J., Schmaljohn A., Schmaljohn C.
Virology 246:134-144(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Chain P.S.G., Ichou M.A., Malfatti S.A., Hajjaj A., Vergez L.M., Paragas J., Do L.H., Jahrling P.B., Smith K.L., McCready P.M., Ibrahim M.S.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF054908 mRNA. Translation: AAC09342.1.
AY354458 Genomic RNA. Translation: AAQ55045.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008609. Ebola_NP.
[Graphical view]
PfamPF05505. Ebola_NP. 1 hit.
[Graphical view]
PIRSFPIRSF003900. N_FiloV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNCAP_EBOZ5
AccessionPrimary (citable) accession number: O72142
Secondary accession number(s): Q6V1R0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 16, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families