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O72120 (CAPSD_CACV4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name=CP
VP1
Gene names
ORF Names:ORF2
OrganismCanine calicivirus (strain 48) (CaCV)
Taxonomic identifier292348 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridae
Virus hostCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to specific cellular receptor. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm By similarity.

Subunit structure

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins By similarity.

Subcellular location

Virion. Host cytoplasm By similarity.

Post-translational modification

Cleaved by virus calcivirin to produce mature capsid protein By similarity.

Sequence similarities

Belongs to the caliciviridae capsid protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 157157
PRO_0000036872
Chain158 – 691534Capsid protein
PRO_0000036873

Sites

Site157 – 1582Cleavage; by 3C-like protease

Experimental info

Mutagenesis1571E → K: Complete loss of processing by the viral protease. Ref.3
Mutagenesis1581S → P: Complete loss of processing by the viral protease. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O72120 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: F1C9774C9217AEF4

FASTA69176,181
        10         20         30         40         50         60 
MARYLELNPQ NYSDEEYDYD SYNPFPNFEK NLASHYGTDF VPRINLDDFF LDDEDFEFCD 

        70         80         90        100        110        120 
DPLNCCFPDY LASLGEEEFI YEGDEPYIVL KHQLVSSTMW DDGTFTYPIL PPFKTSSISY 

       130        140        150        160        170        180 
FLPKPGEVLH RCLMAVAKGM DPDLQVAVGT EFQFRAESDS SHPPDITTED QGTVVATGPQ 

       190        200        210        220        230        240 
PSAPAMATLA TAATGTMPEE WKNFFSYYTT INWATTDETG KVLFVQNLAP RMNPFLDHIA 

       250        260        270        280        290        300 
KMYTGWSGSM EVRFTISGSG VFGGKVAAVL VPPGISTEGG TNLLQFPHVL VDARQTEPVI 

       310        320        330        340        350        360 
FTIPDIRTQL WHDMHDTSTS HLVILVYNDL VNPFQGGENG TSCTITVETR GGTDFEFHLL 

       370        380        390        400        410        420 
KPPTRKMIFG ADPSRLIPRR SQFWEGNRLP GVITSFVCLP RMFQANRHFD CKRQTFGWSR 

       430        440        450        460        470        480 
PVHKGIEVRV DATNKDAANT TDIGIHVVTA RNAIKSDIPD GWPDYYRTGE QVYNNTTQTF 

       490        500        510        520        530        540 
QEVKESVMGS AVPDSTATAM TWHHLPTVVF GHGTAVGSKT TNSKVLSGNF YAIGNFDQSG 

       550        560        570        580        590        600 
NIKLYPSYWI AKEQSAGGAP IGAYEDMVKR IDVLPTAQTT GGNFPVAFVS KFASSHNGNG 

       610        620        630        640        650        660 
VSVYNSQILT TSALLAQDVY DIGPNALAVF KIKGSGGYWF DLGISADGFS YVGGGNLNFS 

       670        680        690 
SLQFPLEATY VGMASLHNKL QYNLGGSATT L 

« Hide

References

[1]"Organization of the canine calicivirus genome from the RNA polymerase gene to the poly(A) tail."
Roerink F., Hashimoto M., Tohya Y., Mochizuki M.
J. Gen. Virol. 80:929-935(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Complete nucleotide sequence, genome organization and phylogenic analysis of the canine calicivirus."
Matsuura Y., Tohya Y., Nakamura K., Shimojima M., Roerink F., Mochizuki M., Takase K., Akashi H., Sugimura T.
Virus Genes 25:67-73(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"Expression and processing of the canine calicivirus capsid precursor."
Matsuura Y., Tohya Y., Onuma M., Roerink F., Mochizuki M., Sugimura T.
J. Gen. Virol. 81:195-199(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEOLYTIC PROCESSING, MUTAGENESIS OF GLU-157 AND SER-158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF053720 Genomic RNA. Translation: AAC16446.1.
AB070225 Genomic RNA. Translation: BAB83602.1.
RefSeqNP_777374.1. NC_004542.1.

3D structure databases

ProteinModelPortalO72120.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956315.

Family and domain databases

InterProIPR004005. Calicivirus_coat.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPSD_CACV4
AccessionPrimary (citable) accession number: O72120
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: August 1, 1998
Last modified: May 29, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families