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O72120

- CAPSD_CACV4

UniProt

O72120 - CAPSD_CACV4

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Protein

Capsid protein

Gene

ORF2

Organism
Canine calicivirus (strain 48) (CaCV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to specific cellular receptor. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1582Cleavage; by 3C-like protease

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
VP1
Gene namesi
ORF Names:ORF2
OrganismiCanine calicivirus (strain 48) (CaCV)
Taxonomic identifieri292348 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridae
Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]

Subcellular locationi

Virion. Host cytoplasm By similarity

GO - Cellular componenti

  1. host cell cytoplasm Source: UniProtKB-KW
  2. T=3 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi157 – 1571E → K: Complete loss of processing by the viral protease. 1 Publication
Mutagenesisi158 – 1581S → P: Complete loss of processing by the viral protease. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 157157PRO_0000036872Add
BLAST
Chaini158 – 691534Capsid proteinPRO_0000036873Add
BLAST

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein.By similarity

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO72120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O72120-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARYLELNPQ NYSDEEYDYD SYNPFPNFEK NLASHYGTDF VPRINLDDFF
60 70 80 90 100
LDDEDFEFCD DPLNCCFPDY LASLGEEEFI YEGDEPYIVL KHQLVSSTMW
110 120 130 140 150
DDGTFTYPIL PPFKTSSISY FLPKPGEVLH RCLMAVAKGM DPDLQVAVGT
160 170 180 190 200
EFQFRAESDS SHPPDITTED QGTVVATGPQ PSAPAMATLA TAATGTMPEE
210 220 230 240 250
WKNFFSYYTT INWATTDETG KVLFVQNLAP RMNPFLDHIA KMYTGWSGSM
260 270 280 290 300
EVRFTISGSG VFGGKVAAVL VPPGISTEGG TNLLQFPHVL VDARQTEPVI
310 320 330 340 350
FTIPDIRTQL WHDMHDTSTS HLVILVYNDL VNPFQGGENG TSCTITVETR
360 370 380 390 400
GGTDFEFHLL KPPTRKMIFG ADPSRLIPRR SQFWEGNRLP GVITSFVCLP
410 420 430 440 450
RMFQANRHFD CKRQTFGWSR PVHKGIEVRV DATNKDAANT TDIGIHVVTA
460 470 480 490 500
RNAIKSDIPD GWPDYYRTGE QVYNNTTQTF QEVKESVMGS AVPDSTATAM
510 520 530 540 550
TWHHLPTVVF GHGTAVGSKT TNSKVLSGNF YAIGNFDQSG NIKLYPSYWI
560 570 580 590 600
AKEQSAGGAP IGAYEDMVKR IDVLPTAQTT GGNFPVAFVS KFASSHNGNG
610 620 630 640 650
VSVYNSQILT TSALLAQDVY DIGPNALAVF KIKGSGGYWF DLGISADGFS
660 670 680 690
YVGGGNLNFS SLQFPLEATY VGMASLHNKL QYNLGGSATT L
Length:691
Mass (Da):76,181
Last modified:August 1, 1998 - v1
Checksum:iF1C9774C9217AEF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053720 Genomic RNA. Translation: AAC16446.1.
AB070225 Genomic RNA. Translation: BAB83602.1.
RefSeqiNP_777374.1. NC_004542.1.

Genome annotation databases

GeneIDi956315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053720 Genomic RNA. Translation: AAC16446.1 .
AB070225 Genomic RNA. Translation: BAB83602.1 .
RefSeqi NP_777374.1. NC_004542.1.

3D structure databases

ProteinModelPortali O72120.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956315.

Family and domain databases

Gene3Di 2.60.120.20. 1 hit.
InterProi IPR004005. Calicivirus_coat.
IPR029053. Viral_coat.
[Graphical view ]
Pfami PF00915. Calici_coat. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Organization of the canine calicivirus genome from the RNA polymerase gene to the poly(A) tail."
    Roerink F., Hashimoto M., Tohya Y., Mochizuki M.
    J. Gen. Virol. 80:929-935(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Complete nucleotide sequence, genome organization and phylogenic analysis of the canine calicivirus."
    Matsuura Y., Tohya Y., Nakamura K., Shimojima M., Roerink F., Mochizuki M., Takase K., Akashi H., Sugimura T.
    Virus Genes 25:67-73(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "Expression and processing of the canine calicivirus capsid precursor."
    Matsuura Y., Tohya Y., Onuma M., Roerink F., Mochizuki M., Sugimura T.
    J. Gen. Virol. 81:195-199(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING, MUTAGENESIS OF GLU-157 AND SER-158.

Entry informationi

Entry nameiCAPSD_CACV4
AccessioniPrimary (citable) accession number: O72120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3