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Protein

Capsid protein

Gene

ORF2

Organism
Canine calicivirus (strain 48) (CaCV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate the genomic RNA and VP2 proteins. Attaches virion to target cells by binding to specific cellular receptor. Once attached, the virion is endocytosed. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
VP1
Gene namesi
ORF Names:ORF2
OrganismiCanine calicivirus (strain 48) (CaCV)
Taxonomic identifieri292348 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageCaliciviridaeVesivirusunclassified Vesivirus
Virus hostiCanis lupus familiaris (Dog) (Canis familiaris) [TaxID: 9615]

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host cytoplasm, T=3 icosahedral capsid protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi157E → K: Complete loss of processing by the viral protease. 1 Publication1
Mutagenesisi158S → P: Complete loss of processing by the viral protease. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000368721 – 157Add BLAST157
ChainiPRO_0000036873158 – 691Capsid proteinAdd BLAST534

Post-translational modificationi

Cleaved by virus calcivirin to produce mature capsid protein.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157 – 158Cleavage; by 3C-like protease2

Interactioni

Subunit structurei

Homodimerizes, then multimerizes. May bind to VP3 and Vpg proteins (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO72120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd00205. rhv_like. 1 hit.
Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR033703. Rhv-like.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O72120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYLELNPQ NYSDEEYDYD SYNPFPNFEK NLASHYGTDF VPRINLDDFF
60 70 80 90 100
LDDEDFEFCD DPLNCCFPDY LASLGEEEFI YEGDEPYIVL KHQLVSSTMW
110 120 130 140 150
DDGTFTYPIL PPFKTSSISY FLPKPGEVLH RCLMAVAKGM DPDLQVAVGT
160 170 180 190 200
EFQFRAESDS SHPPDITTED QGTVVATGPQ PSAPAMATLA TAATGTMPEE
210 220 230 240 250
WKNFFSYYTT INWATTDETG KVLFVQNLAP RMNPFLDHIA KMYTGWSGSM
260 270 280 290 300
EVRFTISGSG VFGGKVAAVL VPPGISTEGG TNLLQFPHVL VDARQTEPVI
310 320 330 340 350
FTIPDIRTQL WHDMHDTSTS HLVILVYNDL VNPFQGGENG TSCTITVETR
360 370 380 390 400
GGTDFEFHLL KPPTRKMIFG ADPSRLIPRR SQFWEGNRLP GVITSFVCLP
410 420 430 440 450
RMFQANRHFD CKRQTFGWSR PVHKGIEVRV DATNKDAANT TDIGIHVVTA
460 470 480 490 500
RNAIKSDIPD GWPDYYRTGE QVYNNTTQTF QEVKESVMGS AVPDSTATAM
510 520 530 540 550
TWHHLPTVVF GHGTAVGSKT TNSKVLSGNF YAIGNFDQSG NIKLYPSYWI
560 570 580 590 600
AKEQSAGGAP IGAYEDMVKR IDVLPTAQTT GGNFPVAFVS KFASSHNGNG
610 620 630 640 650
VSVYNSQILT TSALLAQDVY DIGPNALAVF KIKGSGGYWF DLGISADGFS
660 670 680 690
YVGGGNLNFS SLQFPLEATY VGMASLHNKL QYNLGGSATT L
Length:691
Mass (Da):76,181
Last modified:August 1, 1998 - v1
Checksum:iF1C9774C9217AEF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053720 Genomic RNA. Translation: AAC16446.1.
AB070225 Genomic RNA. Translation: BAB83602.1.
RefSeqiNP_777374.1. NC_004542.1.

Genome annotation databases

GeneIDi956315.
KEGGivg:956315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053720 Genomic RNA. Translation: AAC16446.1.
AB070225 Genomic RNA. Translation: BAB83602.1.
RefSeqiNP_777374.1. NC_004542.1.

3D structure databases

ProteinModelPortaliO72120.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956315.
KEGGivg:956315.

Family and domain databases

CDDicd00205. rhv_like. 1 hit.
Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR033703. Rhv-like.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAPSD_CACV4
AccessioniPrimary (citable) accession number: O72120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.