Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O71028

- DUT_SIRV1

UniProt

O71028 - DUT_SIRV1

Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

158a

Organism
Sulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It does probably not deaminate dCTP.1 Publication

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.1 Publication

    Cofactori

    Magnesium.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. dCTP deaminase activity Source: InterPro
    2. dUTP diphosphatase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00610; UER00665.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
    Short name:
    dUTPase
    Alternative name(s):
    dUTP pyrophosphatase
    Gene namesi
    ORF Names:158a
    OrganismiSulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
    Taxonomic identifieri157898 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageLigamenviralesRudiviridaeRudivirus
    Virus hostiSulfolobus islandicus [TaxID: 43080]
    ProteomesiUP000002270: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000342288Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO71028.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dUTPase family.Curated

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00146. dCTP_deaminase.
    InterProiIPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O71028-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILSDRDIKT YINSKKLVIN PLSEDTIREN GVDLKIGNEI VRIKENMEKE    50
    VGDEFIIYPN EHVLLTTKEY IKLSNDIIAF CNLRSTFARK GLLIPPTIVD 100
    AGFEGQLTIE LVGSSIPVKL KSGERFLHLI FARTLTPVEK PYNGKYQKQK 150
    GVTLAKED 158
    Length:158
    Mass (Da):17,906
    Last modified:August 1, 1998 - v1
    Checksum:i5BA47765E0889190
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101T → R in strain: Isolate variant XX.
    Natural varianti15 – 151K → N in strain: Isolate variant XX.
    Natural varianti20 – 201N → D in strain: Isolate variant XX.
    Natural varianti133 – 1331R → H in strain: Isolate variant XX.
    Natural varianti148 – 1481K → N in strain: Isolate variant XX.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022221 Genomic DNA. Translation: AAC15873.1.
    AJ414696 Genomic DNA. Translation: CAC93972.1.
    AJ748296 Genomic DNA. Translation: CAG38836.1.
    RefSeqiNP_666605.1. NC_004087.1.

    Genome annotation databases

    GeneIDi951366.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022221 Genomic DNA. Translation: AAC15873.1 .
    AJ414696 Genomic DNA. Translation: CAC93972.1 .
    AJ748296 Genomic DNA. Translation: CAG38836.1 .
    RefSeqi NP_666605.1. NC_004087.1.

    3D structure databases

    ProteinModelPortali O71028.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 951366.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00665 .

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00146. dCTP_deaminase.
    InterProi IPR011962. dCTP_deam.
    IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR02274. dCTP_deam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical and phylogenetic characterization of the dUTPase from the archaeal virus SIRV."
      Prangishvili D., Klenk H.-P., Jakobs G., Schmiechen A., Hanselmann C., Holz I., Zillig W.
      J. Biol. Chem. 273:6024-6029(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, COFACTOR, ENZYME ACTIVITY.
    2. "Sequences and replication of genomes of the archaeal rudiviruses SIRV1 and SIRV2: relationships to the archaeal lipothrixvirus SIFV and some eukaryal viruses."
      Peng X., Blum H., She Q., Mallok S., Bruegger K., Garrett R.A., Zillig W., Prangishvili D.
      Virology 291:226-234(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate variant VIII.
    3. "Multiple variants of the archaeal DNA rudivirus SIRV1 in a single host and a novel mechanism of genomic variation."
      Peng X., Kessler A., Phan H., Garrett R.A., Prangishvili D.
      Mol. Microbiol. 54:366-375(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate variant XX.

    Entry informationi

    Entry nameiDUT_SIRV1
    AccessioniPrimary (citable) accession number: O71028
    Secondary accession number(s): Q5TJA2, Q777W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3