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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

158a

Organism
Sulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It does probably not deaminate dCTP.1 Publication

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.1 Publication

Cofactori

Mg2+1 Publication

Pathway:idUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (158a)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.23. 410.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:158a
OrganismiSulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
Taxonomic identifieri157898 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageLigamenviralesRudiviridaeRudivirus
Virus hostiSulfolobus islandicus [TaxID: 43080]
ProteomesiUP000002270 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Probable deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000342288Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO71028.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

KOiK01494.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

O71028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRDIKT YINSKKLVIN PLSEDTIREN GVDLKIGNEI VRIKENMEKE
60 70 80 90 100
VGDEFIIYPN EHVLLTTKEY IKLSNDIIAF CNLRSTFARK GLLIPPTIVD
110 120 130 140 150
AGFEGQLTIE LVGSSIPVKL KSGERFLHLI FARTLTPVEK PYNGKYQKQK

GVTLAKED
Length:158
Mass (Da):17,906
Last modified:August 1, 1998 - v1
Checksum:i5BA47765E0889190
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101T → R in strain: Isolate variant XX.
Natural varianti15 – 151K → N in strain: Isolate variant XX.
Natural varianti20 – 201N → D in strain: Isolate variant XX.
Natural varianti133 – 1331R → H in strain: Isolate variant XX.
Natural varianti148 – 1481K → N in strain: Isolate variant XX.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022221 Genomic DNA. Translation: AAC15873.1.
AJ414696 Genomic DNA. Translation: CAC93972.1.
AJ748296 Genomic DNA. Translation: CAG38836.1.
RefSeqiNP_666605.1. NC_004087.1.

Genome annotation databases

GeneIDi951366.
KEGGivg:951366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022221 Genomic DNA. Translation: AAC15873.1.
AJ414696 Genomic DNA. Translation: CAC93972.1.
AJ748296 Genomic DNA. Translation: CAG38836.1.
RefSeqiNP_666605.1. NC_004087.1.

3D structure databases

ProteinModelPortaliO71028.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi951366.
KEGGivg:951366.

Phylogenomic databases

KOiK01494.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.
BRENDAi3.6.1.23. 410.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Biochemical and phylogenetic characterization of the dUTPase from the archaeal virus SIRV."
    Prangishvili D., Klenk H.-P., Jakobs G., Schmiechen A., Hanselmann C., Holz I., Zillig W.
    J. Biol. Chem. 273:6024-6029(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, COFACTOR, ENZYME ACTIVITY.
  2. "Sequences and replication of genomes of the archaeal rudiviruses SIRV1 and SIRV2: relationships to the archaeal lipothrixvirus SIFV and some eukaryal viruses."
    Peng X., Blum H., She Q., Mallok S., Bruegger K., Garrett R.A., Zillig W., Prangishvili D.
    Virology 291:226-234(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate variant VIII.
  3. "Multiple variants of the archaeal DNA rudivirus SIRV1 in a single host and a novel mechanism of genomic variation."
    Peng X., Kessler A., Phan H., Garrett R.A., Prangishvili D.
    Mol. Microbiol. 54:366-375(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate variant XX.

Entry informationi

Entry nameiDUT_SIRV1
AccessioniPrimary (citable) accession number: O71028
Secondary accession number(s): Q5TJA2, Q777W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 1, 1998
Last modified: April 1, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.