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Protein

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

158a

Organism
Sulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It does probably not deaminate dCTP.1 Publication

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.1 Publication

Cofactori

Mg2+1 Publication

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (158a)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.23 410
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
ORF Names:158a
OrganismiSulfolobus islandicus rod-shaped virus 1 (SIRV-1) (Sulfolobus virus SIRV-1)
Taxonomic identifieri157898 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageLigamenviralesRudiviridaeRudivirus
Virus hostiSulfolobus islandicus [TaxID: 43080]
Proteomesi
  • UP000002270 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422881 – 158Probable deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST158

Structurei

3D structure databases

ProteinModelPortaliO71028
SMRiO71028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Phylogenomic databases

KOiK01494
OrthoDBiVOG0900028V

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

O71028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRDIKT YINSKKLVIN PLSEDTIREN GVDLKIGNEI VRIKENMEKE
60 70 80 90 100
VGDEFIIYPN EHVLLTTKEY IKLSNDIIAF CNLRSTFARK GLLIPPTIVD
110 120 130 140 150
AGFEGQLTIE LVGSSIPVKL KSGERFLHLI FARTLTPVEK PYNGKYQKQK

GVTLAKED
Length:158
Mass (Da):17,906
Last modified:August 1, 1998 - v1
Checksum:i5BA47765E0889190
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti10T → R in strain: Isolate variant XX. 1
Natural varianti15K → N in strain: Isolate variant XX. 1
Natural varianti20N → D in strain: Isolate variant XX. 1
Natural varianti133R → H in strain: Isolate variant XX. 1
Natural varianti148K → N in strain: Isolate variant XX. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022221 Genomic DNA Translation: AAC15873.1
AJ414696 Genomic DNA Translation: CAC93972.1
AJ748296 Genomic DNA Translation: CAG38836.1
RefSeqiNP_666605.1, NC_004087.1

Genome annotation databases

GeneIDi951366
KEGGivg:951366

Similar proteinsi

Entry informationi

Entry nameiDUT_SIRV1
AccessioniPrimary (citable) accession number: O71028
Secondary accession number(s): Q5TJA2, Q777W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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