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Protein
Submitted name:

Gag-pro-pol polyprotein

Gene
N/A
Organism
Simian T-lymphotropic virus 2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integration, DNA recombinationSAAS annotation, Viral genome integrationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

DNA-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Gag-pro-pol polyproteinImported
OrganismiSimian T-lymphotropic virus 2Imported
Taxonomic identifieri33748 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeDeltaretrovirus

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Virion

Structurei

3D structure databases

ProteinModelPortaliO70641.
SMRiO70641. Positions 1-135, 151-349, 443-558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini362 – 37514CCHC-typeInterPro annotationAdd
BLAST
Domaini469 – 54779Peptidase A2InterPro annotationAdd
BLAST
Domaini619 – 809191Reverse transcriptaseInterPro annotationAdd
BLAST
Domaini1036 – 1171136RNase HInterPro annotationAdd
BLAST
Domaini1225 – 1383159Integrase catalyticInterPro annotationAdd
BLAST
Domaini1399 – 144850Integrase-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains CCHC-type zinc fingers.SAAS annotation
Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains integrase-type DNA-binding domain.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.185.10. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR003139. D_retro_matrix.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR003308. Integrase_Zn-bd_dom_N.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02228. Gag_p19. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQTYGLSSS PIPKAPRGLS THHWLNFLQA AYRLQPGPSD FDFQQLRRFL
60 70 80 90 100
KLALKTPIWL NPIDYSLLAS LIPKGYPGRT IEIINVLIKN QTSPTPPPAP
110 120 130 140 150
SLPEPANPPP LQQPSAPPEP HTPPPYIKPP ATHCLPILHP HGAPSAHSPW
160 170 180 190 200
QMKDLQAIKQ EVSTSAPGSP QFMQTVRLAI QQFDPTAKDL QDLLQYLCSS
210 220 230 240 250
LVVSLHHQQF HTLITEAETR GMTGYNPMAG PLRMQANNPA QQGLRREYQN
260 270 280 290 300
LWLAAFSALP GNTRDPSWAA ILQGLEEPYC AFVERLNVAL DNGLPEGTPK
310 320 330 340 350
EPILRSLAYS NANKDCQKLL QARGHTNSPL GDMLRACQAW TPKDKARVLV
360 370 380 390 400
VQPRKPPPTQ PCFRCGKTGH WSRDCTLPRP PPGPCPLCKD PSHWKRDCPQ
410 420 430 440 450
FKPPPTEEEP LLLDLPSDAI ATEEKKLPGG GDVISPQQIS MLPVIPLEQQ
460 470 480 490 500
HQPLLDVQVS IAGAPPRPTQ ALLDTGADLT VLPQALAPES VSVSDTTVLG
510 520 530 540 550
AGGQTSSQFK LLQSPLCVYL PFRRAPVTLP SCLVDTNSKW AIIGRDILQK
560 570 580 590 600
CQSVLYLPED NLCKGTPRLP DGITPPRLLP VTTPNVIGLE HFPPPPQIDQ
610 620 630 640 650
FPFKPERLQA LTDLVSKALE ASYIEPYSGP GNNPVFPVKK PNGKWRFIHD
660 670 680 690 700
LRATNAITTT LASPSPGPPD LTSLSTALPY LQTIDLTDAF FQIPLPKQFQ
710 720 730 740 750
PYFAFTIPQP CNYGPGARYA WTVLPQGFKN SPTLFEQQLA AVLSPIRKTF
760 770 780 790 800
PMSTIIQYMD DILLASPTQE ELQQLSKMTL QALVTHGLPV SQEKTQQTPG
810 820 830 840 850
QIRFLGQVIS PNHITYETTP TIPIKSQWTL TELQTVLGEI QWVSKGTPIL
860 870 880 890 900
RKHLQCLYSA LRGYQDPRAH LLLQKQQLHA LHAIQQALQH NCRSRLNPAL
910 920 930 940 950
PILGLISLSS SGTTSVLFQA RQRWPLVWLH TPHPPTSLCP WGHLLACTIL
960 970 980 990 1000
TLDKYSLQHY GQLCQSFHHN MSNTALHDFV KNSPHPSVGI LIHHMGRFHN
1010 1020 1030 1040 1050
LGSQPSGPWR TLLHLPALLQ EPRLLRPLFT LSPVVLTTAP CLFSDGSSQK
1060 1070 1080 1090 1100
AAYVLWDQTI LHHDSVTLPP HGSNSAQKGE LLALLSGIRA AKSWPSLNIF
1110 1120 1130 1140 1150
LDSKYLIKYL HSLAIGAFLG TSTHQSLYAH LPTLLHNKVI YLHHIRSHTN
1160 1170 1180 1190 1200
LPDPISTLNE YTDSLIIAPL IPLTPQDLHK LTHCNSRALV SSGATPQQAK
1210 1220 1230 1240 1250
SLLQTCYTCN IINSQHHMPQ GHIRRGLMPN HIWQGDVTHY KYKRNRYCLH
1260 1270 1280 1290 1300
VWVDTFSNAV SITCKTKETS SETVSALLHA ITILGKPLSI NTDNGSAFLS
1310 1320 1330 1340 1350
QEFQAFCASW HIKHSTHVPY NSTSSGLVER TNGIVKALLN KYLLDSPNLP
1360 1370 1380 1390 1400
LDNAISKALW TLNQLNVMSS QWKTRWQLHH GPRLRPIPET PRPSRAPTNW
1410 1420 1430 1440 1450
YYYKLPGLTN QRWKGPLQSL QEAAGAALLS IDGSPQWIPW RLLKKTVCPR
1460
PDGSELVAHA ATDHQHHG
Length:1,468
Mass (Da):162,942
Last modified:August 1, 1998 - v1
Checksum:i5B15126219EBD455
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14570 Genomic DNA. Translation: CAA74901.1.
RefSeqiNP_056907.1. NC_001815.1.

Genome annotation databases

GeneIDi1724974.
KEGGivg:1724974.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14570 Genomic DNA. Translation: CAA74901.1.
RefSeqiNP_056907.1. NC_001815.1.

3D structure databases

ProteinModelPortaliO70641.
SMRiO70641. Positions 1-135, 151-349, 443-558.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1724974.
KEGGivg:1724974.

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.185.10. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR003139. D_retro_matrix.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR003308. Integrase_Zn-bd_dom_N.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02228. Gag_p19. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO70641_9DELA
AccessioniPrimary (citable) accession number: O70641
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.