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Protein

Reticulon-2

Gene

Rtn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • intracellular protein transmembrane transport Source: MGI
  • regulation of glucose import Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-2
Alternative name(s):
Neuroendocrine-specific protein-like 1
Short name:
NSP-like protein 1
Neuroendocrine-specific protein-like I
Short name:
NSP-like protein I
Short name:
NSPLI
Gene namesi
Name:Rtn2
Synonyms:Nspl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107612. Rtn2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei295 – 31521HelicalSequence analysisAdd
BLAST
Transmembranei390 – 41021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • terminal cisterna Source: MGI
  • T-tubule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Reticulon-2PRO_0000168162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei226 – 2261PhosphoserineCombined sources
Modified residuei228 – 2281PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO70622.
PeptideAtlasiO70622.
PRIDEiO70622.

PTM databases

iPTMnetiO70622.
PhosphoSiteiO70622.

Expressioni

Tissue specificityi

Expressed predominantly in neural and muscular tissues.1 Publication

Gene expression databases

BgeeiO70622.
CleanExiMM_RTN2.
ExpressionAtlasiO70622. baseline and differential.
GenevisibleiO70622. MM.

Interactioni

Subunit structurei

Interacts with SPAST. Interacts with TMEM33.By similarity

Protein-protein interaction databases

BioGridi203033. 1 interaction.
IntActiO70622. 1 interaction.
MINTiMINT-4133316.
STRINGi10090.ENSMUSP00000032559.

Structurei

3D structure databases

ProteinModelPortaliO70622.
SMRiO70622. Positions 321-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini272 – 471200ReticulonPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
HOGENOMiHOG000015254.
HOVERGENiHBG099866.
InParanoidiO70622.
OMAiQCLDSTD.
OrthoDBiEOG7CZK7J.
PhylomeDBiO70622.
TreeFamiTF105431.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70622-1) [UniParc]FASTAAdd to basket

Also known as: Brain

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQVLPVFAH CKEAPSTASS TPDSTEGGND DSDFRELHTA REFSEDEEEE
60 70 80 90 100
TTSQDWGTPR ELTFSYIAFD GVVGSGGRRD SVVRRPRPQG RSVSEPRDPP
110 120 130 140 150
QQSGLGDSLE SIPSLSQSPE PGRRGDPDPV PPAERPLEEL RLRLDQLGWV
160 170 180 190 200
VRSAGSGEDS ATSSSTPLEN EEPDGLEASE AGEETNLELR LAQSLHLQLE
210 220 230 240 250
VLTPQLSPSS GTPQAHTPSP QRSQDSNSGP DDEPLLNVVE EHWRLLEQEP
260 270 280 290 300
ITAQCLDSTD QSEFMLEPLL LVADLLYWKD TRTSGAVFTG LMASLLCLLH
310 320 330 340 350
FSIVSVAAHL ALLGLCATIS LRVYRKVLQA VHRGDGTNPF QAYLDMDLTL
360 370 380 390 400
TREQTERLSQ QIASHVVSTA TQLRHFFLVE DLVDSLKLAL LFYILTFVGA
410 420 430 440 450
IFNGLTLVIL GVVALFTVPL LYRQHQAQID QYVGLVTNQL SHIKAKIRAK
460 470
IPGTGTLAPT ASVSGSKAKA E
Length:471
Mass (Da):51,347
Last modified:August 1, 1998 - v1
Checksum:i9BBD8F372CF63AD3
GO
Isoform 2 (identifier: O70622-2) [UniParc]FASTAAdd to basket

Also known as: Muscle

The sequence of this isoform differs from the canonical sequence as follows:
     1-267: Missing.
     268-271: PLLL → MGSK

Show »
Length:204
Mass (Da):22,239
Checksum:i07AFC32A9BAA6930
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 267267Missing in isoform 2. 1 PublicationVSP_005650Add
BLAST
Alternative sequencei268 – 2714PLLL → MGSK in isoform 2. 1 PublicationVSP_005651

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038537 Genomic DNA. Translation: AAC14906.1.
AF038537 Genomic DNA. Translation: AAC14907.1.
AF038538 mRNA. Translation: AAC14908.1.
AF038539 mRNA. Translation: AAC14909.1.
AF093624 Genomic DNA. Translation: AAD13195.1.
BC031370 mRNA. Translation: AAH31370.1.
CCDSiCCDS20896.1. [O70622-1]
CCDS39797.1. [O70622-2]
RefSeqiNP_001020535.1. NM_001025364.3. [O70622-2]
NP_038676.1. NM_013648.6. [O70622-1]
UniGeneiMm.24142.

Genome annotation databases

EnsembliENSMUST00000032559; ENSMUSP00000032559; ENSMUSG00000030401. [O70622-1]
ENSMUST00000108468; ENSMUSP00000104108; ENSMUSG00000030401. [O70622-2]
GeneIDi20167.
KEGGimmu:20167.
UCSCiuc009flh.2. mouse. [O70622-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038537 Genomic DNA. Translation: AAC14906.1.
AF038537 Genomic DNA. Translation: AAC14907.1.
AF038538 mRNA. Translation: AAC14908.1.
AF038539 mRNA. Translation: AAC14909.1.
AF093624 Genomic DNA. Translation: AAD13195.1.
BC031370 mRNA. Translation: AAH31370.1.
CCDSiCCDS20896.1. [O70622-1]
CCDS39797.1. [O70622-2]
RefSeqiNP_001020535.1. NM_001025364.3. [O70622-2]
NP_038676.1. NM_013648.6. [O70622-1]
UniGeneiMm.24142.

3D structure databases

ProteinModelPortaliO70622.
SMRiO70622. Positions 321-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203033. 1 interaction.
IntActiO70622. 1 interaction.
MINTiMINT-4133316.
STRINGi10090.ENSMUSP00000032559.

PTM databases

iPTMnetiO70622.
PhosphoSiteiO70622.

Proteomic databases

PaxDbiO70622.
PeptideAtlasiO70622.
PRIDEiO70622.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032559; ENSMUSP00000032559; ENSMUSG00000030401. [O70622-1]
ENSMUST00000108468; ENSMUSP00000104108; ENSMUSG00000030401. [O70622-2]
GeneIDi20167.
KEGGimmu:20167.
UCSCiuc009flh.2. mouse. [O70622-1]

Organism-specific databases

CTDi6253.
MGIiMGI:107612. Rtn2.

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
HOGENOMiHOG000015254.
HOVERGENiHBG099866.
InParanoidiO70622.
OMAiQCLDSTD.
OrthoDBiEOG7CZK7J.
PhylomeDBiO70622.
TreeFamiTF105431.

Miscellaneous databases

ChiTaRSiRtn2. mouse.
PROiO70622.
SOURCEiSearch...

Gene expression databases

BgeeiO70622.
CleanExiMM_RTN2.
ExpressionAtlasiO70622. baseline and differential.
GenevisibleiO70622. MM.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel mouse gene with predominant muscle and neural expression."
    Geisler J.G., Stubbs L.J., Wasserman W.W., Mucenski M.L.
    Mamm. Genome 9:274-282(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: 129/Sv and FVB/N.
    Tissue: Cerebellum and Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retina.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44; SER-226 AND SER-228, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung and Spleen.

Entry informationi

Entry nameiRTN2_MOUSE
AccessioniPrimary (citable) accession number: O70622
Secondary accession number(s): O70620
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.