SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O70617

- KCJ13_RAT

UniProt

O70617 - KCJ13_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inward rectifier potassium channel 13

Gene
Kcnj13
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 13
Alternative name(s):
Inward rectifier K(+) channel Kir7.1
Potassium channel, inwardly rectifying subfamily J member 13
Gene namesi
Name:Kcnj13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi621661. Kcnj13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353Cytoplasmic By similarityAdd
BLAST
Transmembranei54 – 7825Helical; Name=M1; By similarityAdd
BLAST
Topological domaini79 – 10527Extracellular By similarityAdd
BLAST
Intramembranei106 – 11712Helical; Pore-forming; Name=H5; By similarityAdd
BLAST
Intramembranei118 – 1247Pore-forming; By similarity
Topological domaini125 – 1339Extracellular By similarity
Transmembranei134 – 15522Helical; Name=M2; By similarityAdd
BLAST
Topological domaini156 – 360205Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Inward rectifier potassium channel 13PRO_0000154967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011Phosphoserine; by PKC By similarity
Modified residuei287 – 2871Phosphoserine; by PKA By similarity

Post-translational modificationi

Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them By similarity.

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriO70617.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021507.

Structurei

3D structure databases

ProteinModelPortaliO70617.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1246Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280854.
GeneTreeiENSGT00750000117737.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO70617.
KOiK05006.
OMAiASFVVHW.
OrthoDBiEOG7NW69K.
PhylomeDBiO70617.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O70617-1 [UniParc]FASTAAdd to Basket

« Hide

MDSRNCKVNA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD    50
MRWRWMMLVF SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV 100
KHITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA 150
FITGAFVAKI ARPKNRAFSI RFTDLAVVAH KDGKPNLIFQ VANTRPSPLT 200
SVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP LTYYHTITPS 250
SPLATLLQHE TPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA 300
ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN 350
FQIAETGLTE 360
Length:360
Mass (Da):40,637
Last modified:August 1, 1998 - v1
Checksum:iB3D2F6CB8F99FD16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006129 mRNA. Translation: CAA06879.1.
AB013890 mRNA. Translation: BAA28272.1.
AB034241 Genomic DNA. Translation: BAA97255.1.
AJ292748 Genomic DNA. Translation: CAC17469.1.
RefSeqiNP_446060.1. NM_053608.2.
XP_006245544.1. XM_006245482.1.
XP_006245545.1. XM_006245483.1.
XP_006245546.1. XM_006245484.1.
XP_006245547.1. XM_006245485.1.
XP_006245548.1. XM_006245486.1.
XP_006245549.1. XM_006245487.1.
UniGeneiRn.14516.

Genome annotation databases

EnsembliENSRNOT00000021507; ENSRNOP00000021507; ENSRNOG00000016057.
GeneIDi94341.
KEGGirno:94341.
UCSCiRGD:621661. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006129 mRNA. Translation: CAA06879.1 .
AB013890 mRNA. Translation: BAA28272.1 .
AB034241 Genomic DNA. Translation: BAA97255.1 .
AJ292748 Genomic DNA. Translation: CAC17469.1 .
RefSeqi NP_446060.1. NM_053608.2.
XP_006245544.1. XM_006245482.1.
XP_006245545.1. XM_006245483.1.
XP_006245546.1. XM_006245484.1.
XP_006245547.1. XM_006245485.1.
XP_006245548.1. XM_006245486.1.
XP_006245549.1. XM_006245487.1.
UniGenei Rn.14516.

3D structure databases

ProteinModelPortali O70617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021507 ; ENSRNOP00000021507 ; ENSRNOG00000016057 .
GeneIDi 94341.
KEGGi rno:94341.
UCSCi RGD:621661. rat.

Organism-specific databases

CTDi 3769.
RGDi 621661. Kcnj13.

Phylogenomic databases

eggNOGi NOG280854.
GeneTreei ENSGT00750000117737.
HOGENOMi HOG000237326.
HOVERGENi HBG006178.
InParanoidi O70617.
KOi K05006.
OMAi ASFVVHW.
OrthoDBi EOG7NW69K.
PhylomeDBi O70617.
TreeFami TF313676.

Miscellaneous databases

NextBioi 617933.
PROi O70617.

Gene expression databases

Genevestigatori O70617.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Unique epithelial Kir7.1 subunit defines a new subfamily of inwardly rectifying potassium channels."
    Doering F., Derst C., Wischmeyer E., Karschin C., Daut J., Karschin A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. Hirose S., Suzuki Y., Nakamura N.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1."
    Nakamura N., Suzuki Y., Ikeda Y., Notoya M., Hirose S.
    J. Biol. Chem. 275:28276-28284(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "Genomic structure and promoter analysis of the rat Kir7.1 potassium channel gene (Kcnj13)."
    Doering F., Karschin A.
    FEBS Lett. 483:93-98(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiKCJ13_RAT
AccessioniPrimary (citable) accession number: O70617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi