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O70617

- KCJ13_RAT

UniProt

O70617 - KCJ13_RAT

Protein

Inward rectifier potassium channel 13

Gene

Kcnj13

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1491Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inward rectifier potassium channel 13
    Alternative name(s):
    Inward rectifier K(+) channel Kir7.1
    Potassium channel, inwardly rectifying subfamily J member 13
    Gene namesi
    Name:Kcnj13
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi621661. Kcnj13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Inward rectifier potassium channel 13PRO_0000154967Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei201 – 2011Phosphoserine; by PKCBy similarity
    Modified residuei287 – 2871Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.By similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriO70617.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021507.

    Structurei

    3D structure databases

    ProteinModelPortaliO70617.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5353CytoplasmicBy similarityAdd
    BLAST
    Topological domaini79 – 10527ExtracellularBy similarityAdd
    BLAST
    Topological domaini125 – 1339ExtracellularBy similarity
    Topological domaini156 – 360205CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei106 – 11712Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei118 – 1247Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7825Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei134 – 15522Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1246Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG280854.
    GeneTreeiENSGT00750000117737.
    HOGENOMiHOG000237326.
    HOVERGENiHBG006178.
    InParanoidiO70617.
    KOiK05006.
    OMAiASFVVHW.
    OrthoDBiEOG7NW69K.
    PhylomeDBiO70617.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    IPR008062. KCNJ13.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF3. PTHR11767:SF3. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01679. KIR7CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O70617-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSRNCKVNA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD    50
    MRWRWMMLVF SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV 100
    KHITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA 150
    FITGAFVAKI ARPKNRAFSI RFTDLAVVAH KDGKPNLIFQ VANTRPSPLT 200
    SVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP LTYYHTITPS 250
    SPLATLLQHE TPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA 300
    ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN 350
    FQIAETGLTE 360
    Length:360
    Mass (Da):40,637
    Last modified:August 1, 1998 - v1
    Checksum:iB3D2F6CB8F99FD16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006129 mRNA. Translation: CAA06879.1.
    AB013890 mRNA. Translation: BAA28272.1.
    AB034241 Genomic DNA. Translation: BAA97255.1.
    AJ292748 Genomic DNA. Translation: CAC17469.1.
    RefSeqiNP_446060.1. NM_053608.2.
    XP_006245544.1. XM_006245482.1.
    XP_006245545.1. XM_006245483.1.
    XP_006245546.1. XM_006245484.1.
    XP_006245547.1. XM_006245485.1.
    XP_006245548.1. XM_006245486.1.
    XP_006245549.1. XM_006245487.1.
    UniGeneiRn.14516.

    Genome annotation databases

    EnsembliENSRNOT00000021507; ENSRNOP00000021507; ENSRNOG00000016057.
    GeneIDi94341.
    KEGGirno:94341.
    UCSCiRGD:621661. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006129 mRNA. Translation: CAA06879.1 .
    AB013890 mRNA. Translation: BAA28272.1 .
    AB034241 Genomic DNA. Translation: BAA97255.1 .
    AJ292748 Genomic DNA. Translation: CAC17469.1 .
    RefSeqi NP_446060.1. NM_053608.2.
    XP_006245544.1. XM_006245482.1.
    XP_006245545.1. XM_006245483.1.
    XP_006245546.1. XM_006245484.1.
    XP_006245547.1. XM_006245485.1.
    XP_006245548.1. XM_006245486.1.
    XP_006245549.1. XM_006245487.1.
    UniGenei Rn.14516.

    3D structure databases

    ProteinModelPortali O70617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021507 ; ENSRNOP00000021507 ; ENSRNOG00000016057 .
    GeneIDi 94341.
    KEGGi rno:94341.
    UCSCi RGD:621661. rat.

    Organism-specific databases

    CTDi 3769.
    RGDi 621661. Kcnj13.

    Phylogenomic databases

    eggNOGi NOG280854.
    GeneTreei ENSGT00750000117737.
    HOGENOMi HOG000237326.
    HOVERGENi HBG006178.
    InParanoidi O70617.
    KOi K05006.
    OMAi ASFVVHW.
    OrthoDBi EOG7NW69K.
    PhylomeDBi O70617.
    TreeFami TF313676.

    Miscellaneous databases

    NextBioi 617933.
    PROi O70617.

    Gene expression databases

    Genevestigatori O70617.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    IPR008062. KCNJ13.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF3. PTHR11767:SF3. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01679. KIR7CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Unique epithelial Kir7.1 subunit defines a new subfamily of inwardly rectifying potassium channels."
      Doering F., Derst C., Wischmeyer E., Karschin C., Daut J., Karschin A.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Brain.
    2. Hirose S., Suzuki Y., Nakamura N.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    3. "Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1."
      Nakamura N., Suzuki Y., Ikeda Y., Notoya M., Hirose S.
      J. Biol. Chem. 275:28276-28284(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.
    4. "Genomic structure and promoter analysis of the rat Kir7.1 potassium channel gene (Kcnj13)."
      Doering F., Karschin A.
      FEBS Lett. 483:93-98(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiKCJ13_RAT
    AccessioniPrimary (citable) accession number: O70617
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3