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Protein

Inward rectifier potassium channel 13

Gene

Kcnj13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 13
Alternative name(s):
Inward rectifier K(+) channel Kir7.1
Potassium channel, inwardly rectifying subfamily J member 13
Gene namesi
Name:Kcnj13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621661. Kcnj13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicBy similarityAdd
BLAST
Transmembranei54 – 7825Helical; Name=M1By similarityAdd
BLAST
Topological domaini79 – 10527ExtracellularBy similarityAdd
BLAST
Intramembranei106 – 11712Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei118 – 1247Pore-formingBy similarity
Topological domaini125 – 1339ExtracellularBy similarity
Transmembranei134 – 15522Helical; Name=M2By similarityAdd
BLAST
Topological domaini156 – 360205CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Inward rectifier potassium channel 13PRO_0000154967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei201 – 2011Phosphoserine; by PKCBy similarity
Modified residuei287 – 2871Phosphoserine; by PKABy similarity

Post-translational modificationi

Phosphorylation at Ser-201 by PKC strongly inhibits ionic currents, while phosphorylation at Ser-287 by PKA increases them.By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

GenevisibleiO70617. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021507.

Structurei

3D structure databases

ProteinModelPortaliO70617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1246Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG280854.
GeneTreeiENSGT00750000117737.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO70617.
KOiK05006.
OMAiASFVVHW.
OrthoDBiEOG7NW69K.
PhylomeDBiO70617.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O70617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRNCKVNA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD
60 70 80 90 100
MRWRWMMLVF SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV
110 120 130 140 150
KHITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA
160 170 180 190 200
FITGAFVAKI ARPKNRAFSI RFTDLAVVAH KDGKPNLIFQ VANTRPSPLT
210 220 230 240 250
SVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP LTYYHTITPS
260 270 280 290 300
SPLATLLQHE TPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA
310 320 330 340 350
ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN
360
FQIAETGLTE
Length:360
Mass (Da):40,637
Last modified:August 1, 1998 - v1
Checksum:iB3D2F6CB8F99FD16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006129 mRNA. Translation: CAA06879.1.
AB013890 mRNA. Translation: BAA28272.1.
AB034241 Genomic DNA. Translation: BAA97255.1.
AJ292748 Genomic DNA. Translation: CAC17469.1.
RefSeqiNP_446060.1. NM_053608.2.
XP_008765523.1. XM_008767301.1.
UniGeneiRn.14516.

Genome annotation databases

EnsembliENSRNOT00000021507; ENSRNOP00000021507; ENSRNOG00000016057.
GeneIDi94341.
KEGGirno:94341.
UCSCiRGD:621661. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006129 mRNA. Translation: CAA06879.1.
AB013890 mRNA. Translation: BAA28272.1.
AB034241 Genomic DNA. Translation: BAA97255.1.
AJ292748 Genomic DNA. Translation: CAC17469.1.
RefSeqiNP_446060.1. NM_053608.2.
XP_008765523.1. XM_008767301.1.
UniGeneiRn.14516.

3D structure databases

ProteinModelPortaliO70617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021507; ENSRNOP00000021507; ENSRNOG00000016057.
GeneIDi94341.
KEGGirno:94341.
UCSCiRGD:621661. rat.

Organism-specific databases

CTDi3769.
RGDi621661. Kcnj13.

Phylogenomic databases

eggNOGiNOG280854.
GeneTreeiENSGT00750000117737.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO70617.
KOiK05006.
OMAiASFVVHW.
OrthoDBiEOG7NW69K.
PhylomeDBiO70617.
TreeFamiTF313676.

Miscellaneous databases

NextBioi617933.
PROiO70617.

Gene expression databases

GenevisibleiO70617. RN.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Unique epithelial Kir7.1 subunit defines a new subfamily of inwardly rectifying potassium channels."
    Doering F., Derst C., Wischmeyer E., Karschin C., Daut J., Karschin A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. Hirose S., Suzuki Y., Nakamura N.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  3. "Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1."
    Nakamura N., Suzuki Y., Ikeda Y., Notoya M., Hirose S.
    J. Biol. Chem. 275:28276-28284(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.
  4. "Genomic structure and promoter analysis of the rat Kir7.1 potassium channel gene (Kcnj13)."
    Doering F., Karschin A.
    FEBS Lett. 483:93-98(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Liver.

Entry informationi

Entry nameiKCJ13_RAT
AccessioniPrimary (citable) accession number: O70617
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1998
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.