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Protein

Gap junction delta-2 protein

Gene

Gjd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • action potential Source: Ensembl
  • cell-cell signaling Source: RGD
  • chemical synaptic transmission Source: Ensembl
  • visual perception Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-2 protein
Alternative name(s):
Connexin-36
Short name:
Cx36
Gap junction alpha-9 protein
Gene namesi
Name:Gjd2
Synonyms:Gja9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2694. Gjd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Topological domaini43 – 75ExtracellularSequence analysisAdd BLAST33
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 197CytoplasmicSequence analysisAdd BLAST99
Transmembranei198 – 220HelicalSequence analysisAdd BLAST23
Topological domaini221 – 252ExtracellularSequence analysisAdd BLAST32
Transmembranei253 – 275HelicalSequence analysisAdd BLAST23
Topological domaini276 – 321CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • connexin complex Source: InterPro
  • gap junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578371 – 321Gap junction delta-2 proteinAdd BLAST321

Proteomic databases

PaxDbiO70610.

Expressioni

Tissue specificityi

Highly expressed in neurons.

Gene expression databases

BgeeiENSRNOG00000008337.
GenevisibleiO70610. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

DIPiDIP-60789N.
STRINGi10116.ENSRNOP00000011078.

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ31. Eukaryota.
ENOG410YRD5. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiO70610.
KOiK07373.
OMAiNKETEPD.
OrthoDBiEOG091G0FB1.
PhylomeDBiO70610.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002260. Connexin36.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01131. CONNEXIN36.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEWTILERL LEAAVQQHST MIGRILLTVV VIFRILIVAI VGETVYDDEQ
60 70 80 90 100
TMFVCNTLQP GCNQACYDRA FPISHIRYWV FQIIMVCTPS LCFITYSVHQ
110 120 130 140 150
SAKQRERRYS TVFLALDRDP AESIGGPGGT GGGGSGGSKR EDKKLQNAIV
160 170 180 190 200
NGVLQNTETT SKETEPDCLE VKELAPHPSG LRTAARSKLR RQEGISRFYI
210 220 230 240 250
IQVVFRNALE IGFLVGQYFL YGFSVPGLYE CNRYPCIKEV ECYVSRPTEK
260 270 280 290 300
TVFLVFMFAV SGICVVLNLA ELNHLGWRKI KLAVRGAQAK RKSVYEIRNK
310 320
DLPRVSVPNF GRTQSSDSAY V
Length:321
Mass (Da):36,052
Last modified:August 1, 1998 - v1
Checksum:i63D4C108214AEF5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57T → A in CAC14913 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16898 mRNA. Translation: CAA76528.1.
AJ296282 mRNA. Translation: CAC14913.1.
RefSeqiNP_062154.1. NM_019281.2.
UniGeneiRn.9904.

Genome annotation databases

EnsembliENSRNOT00000011078; ENSRNOP00000011078; ENSRNOG00000008337.
GeneIDi50564.
KEGGirno:50564.
UCSCiRGD:2694. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16898 mRNA. Translation: CAA76528.1.
AJ296282 mRNA. Translation: CAC14913.1.
RefSeqiNP_062154.1. NM_019281.2.
UniGeneiRn.9904.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60789N.
STRINGi10116.ENSRNOP00000011078.

Proteomic databases

PaxDbiO70610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011078; ENSRNOP00000011078; ENSRNOG00000008337.
GeneIDi50564.
KEGGirno:50564.
UCSCiRGD:2694. rat.

Organism-specific databases

CTDi57369.
RGDi2694. Gjd2.

Phylogenomic databases

eggNOGiENOG410IJ31. Eukaryota.
ENOG410YRD5. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiO70610.
KOiK07373.
OMAiNKETEPD.
OrthoDBiEOG091G0FB1.
PhylomeDBiO70610.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-RNO-112303. Electric Transmission Across Gap Junctions.

Miscellaneous databases

PROiO70610.

Gene expression databases

BgeeiENSRNOG00000008337.
GenevisibleiO70610. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002260. Connexin36.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01131. CONNEXIN36.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXD2_RAT
AccessioniPrimary (citable) accession number: O70610
Secondary accession number(s): Q9ER25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.