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O70596

- KCJ14_RAT

UniProt

O70596 - KCJ14_RAT

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Protein
ATP-sensitive inward rectifier potassium channel 14
Gene
Kcnj14, Irk4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: RGD

GO - Biological processi

  1. potassium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199207. Classical Kir channels.

Protein family/group databases

TCDBi1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:Kcnj14
Synonyms:Irk4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi628872. Kcnj14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484Cytoplasmic By similarity
Add
BLAST
Transmembranei85 – 10925Helical; Name=M1; By similarity
Add
BLAST
Topological domaini110 – 13122Extracellular By similarity
Add
BLAST
Intramembranei132 – 14312Helical; Pore-forming; Name=H5; By similarity
Add
BLAST
Intramembranei144 – 1507Pore-forming; By similarity
Topological domaini151 – 1599Extracellular By similarity
Transmembranei160 – 18122Helical; Name=M2; By similarity
Add
BLAST
Topological domaini182 – 434253Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. dendrite Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434ATP-sensitive inward rectifier potassium channel 14
PRO_0000154970Add
BLAST

Proteomic databases

PaxDbiO70596.
PRIDEiO70596.

Expressioni

Tissue specificityi

Expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column.1 Publication

Gene expression databases

GenevestigatoriO70596.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028591.

Structurei

3D structure databases

ProteinModelPortaliO70596.
SMRiO70596. Positions 190-367.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi145 – 1506Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00650000093228.
HOVERGENiHBG006178.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiO70596.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O70596-1 [UniParc]FASTAAdd to Basket

« Hide

MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGNRRRGRF    50
VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL 100
LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV 150
RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE 200
NAVVALRDRR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH 250
QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI 300
LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT 350
YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLAAFCYEN ELALSCCQEE 400
DEEEDTKEGT SAETPDRAAS PQALTPTLAL TLPP 434
Length:434
Mass (Da):47,609
Last modified:August 1, 1998 - v1
Checksum:iAB586F4628AB42EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ003065 mRNA. Translation: CAA05839.1.
RefSeqiNP_733836.1. NM_170718.1.
UniGeneiRn.154434.

Genome annotation databases

EnsembliENSRNOT00000028591; ENSRNOP00000028591; ENSRNOG00000021056.
GeneIDi276720.
KEGGirno:276720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ003065 mRNA. Translation: CAA05839.1 .
RefSeqi NP_733836.1. NM_170718.1.
UniGenei Rn.154434.

3D structure databases

ProteinModelPortali O70596.
SMRi O70596. Positions 190-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028591.

Chemistry

GuidetoPHARMACOLOGYi 433.

Protein family/group databases

TCDBi 1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

Proteomic databases

PaxDbi O70596.
PRIDEi O70596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000028591 ; ENSRNOP00000028591 ; ENSRNOG00000021056 .
GeneIDi 276720.
KEGGi rno:276720.

Organism-specific databases

CTDi 3770.
RGDi 628872. Kcnj14.

Phylogenomic databases

eggNOGi NOG251076.
GeneTreei ENSGT00650000093228.
HOVERGENi HBG006178.
KOi K05007.
OMAi PCFSQVA.
OrthoDBi EOG7XPZ5K.
PhylomeDBi O70596.

Enzyme and pathway databases

Reactomei REACT_199207. Classical Kir channels.

Miscellaneous databases

NextBioi 624761.
PROi O70596.

Gene expression databases

Genevestigatori O70596.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei."
    Toepert C., Doering F., Wischmeyer E., Karschin C., Brockhaus J., Ballanyi K., Derst C., Karschin A.
    J. Neurosci. 18:4096-4105(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiKCJ14_RAT
AccessioniPrimary (citable) accession number: O70596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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