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O70596

- KCJ14_RAT

UniProt

O70596 - KCJ14_RAT

Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

Kcnj14

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: RGD

    GO - Biological processi

    1. potassium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199207. Classical Kir channels.

    Protein family/group databases

    TCDBi1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 14
    Alternative name(s):
    Inward rectifier K(+) channel Kir2.4
    Short name:
    IRK-4
    Potassium channel, inwardly rectifying subfamily J member 14
    Gene namesi
    Name:Kcnj14
    Synonyms:Irk4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi628872. Kcnj14.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434ATP-sensitive inward rectifier potassium channel 14PRO_0000154970Add
    BLAST

    Proteomic databases

    PaxDbiO70596.
    PRIDEiO70596.

    Expressioni

    Tissue specificityi

    Expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column.1 Publication

    Gene expression databases

    GenevestigatoriO70596.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028591.

    Structurei

    3D structure databases

    ProteinModelPortaliO70596.
    SMRiO70596. Positions 190-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484CytoplasmicBy similarityAdd
    BLAST
    Topological domaini110 – 13122ExtracellularBy similarityAdd
    BLAST
    Topological domaini151 – 1599ExtracellularBy similarity
    Topological domaini182 – 434253CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei132 – 14312Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei144 – 1507Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10925Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei160 – 18122Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi145 – 1506Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG251076.
    GeneTreeiENSGT00650000093228.
    HOVERGENiHBG006178.
    KOiK05007.
    OMAiPCFSQVA.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiO70596.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O70596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGNRRRGRF    50
    VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL 100
    LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV 150
    RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE 200
    NAVVALRDRR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH 250
    QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI 300
    LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT 350
    YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLAAFCYEN ELALSCCQEE 400
    DEEEDTKEGT SAETPDRAAS PQALTPTLAL TLPP 434
    Length:434
    Mass (Da):47,609
    Last modified:August 1, 1998 - v1
    Checksum:iAB586F4628AB42EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003065 mRNA. Translation: CAA05839.1.
    RefSeqiNP_733836.1. NM_170718.1.
    UniGeneiRn.154434.

    Genome annotation databases

    EnsembliENSRNOT00000028591; ENSRNOP00000028591; ENSRNOG00000021056.
    GeneIDi276720.
    KEGGirno:276720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003065 mRNA. Translation: CAA05839.1 .
    RefSeqi NP_733836.1. NM_170718.1.
    UniGenei Rn.154434.

    3D structure databases

    ProteinModelPortali O70596.
    SMRi O70596. Positions 190-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028591.

    Chemistry

    GuidetoPHARMACOLOGYi 433.

    Protein family/group databases

    TCDBi 1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

    Proteomic databases

    PaxDbi O70596.
    PRIDEi O70596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000028591 ; ENSRNOP00000028591 ; ENSRNOG00000021056 .
    GeneIDi 276720.
    KEGGi rno:276720.

    Organism-specific databases

    CTDi 3770.
    RGDi 628872. Kcnj14.

    Phylogenomic databases

    eggNOGi NOG251076.
    GeneTreei ENSGT00650000093228.
    HOVERGENi HBG006178.
    KOi K05007.
    OMAi PCFSQVA.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi O70596.

    Enzyme and pathway databases

    Reactomei REACT_199207. Classical Kir channels.

    Miscellaneous databases

    NextBioi 624761.
    PROi O70596.

    Gene expression databases

    Genevestigatori O70596.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei."
      Toepert C., Doering F., Wischmeyer E., Karschin C., Brockhaus J., Ballanyi K., Derst C., Karschin A.
      J. Neurosci. 18:4096-4105(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCJ14_RAT
    AccessioniPrimary (citable) accession number: O70596
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3