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Protein

ATP-sensitive inward rectifier potassium channel 14

Gene

Kcnj14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium.

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: RGD

GO - Biological processi

  1. potassium ion import Source: GO_Central
  2. regulation of ion transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199207. Classical Kir channels.

Protein family/group databases

TCDBi1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 14
Alternative name(s):
Inward rectifier K(+) channel Kir2.4
Short name:
IRK-4
Potassium channel, inwardly rectifying subfamily J member 14
Gene namesi
Name:Kcnj14
Synonyms:Irk4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi628872. Kcnj14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484CytoplasmicBy similarityAdd
BLAST
Transmembranei85 – 10925Helical; Name=M1By similarityAdd
BLAST
Topological domaini110 – 13122ExtracellularBy similarityAdd
BLAST
Intramembranei132 – 14312Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei144 – 1507Pore-formingBy similarity
Topological domaini151 – 1599ExtracellularBy similarity
Transmembranei160 – 18122Helical; Name=M2By similarityAdd
BLAST
Topological domaini182 – 434253CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: RGD
  2. integral component of plasma membrane Source: GO_Central
  3. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434ATP-sensitive inward rectifier potassium channel 14PRO_0000154970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791S-nitrosocysteineBy similarity

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiO70596.
PRIDEiO70596.

Expressioni

Tissue specificityi

Expressed predominantly in motoneurons of cranial nerve motor nuclei within the general somatic and special visceral motor cell column.1 Publication

Gene expression databases

GenevestigatoriO70596.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028591.

Structurei

3D structure databases

ProteinModelPortaliO70596.
SMRiO70596. Positions 190-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi145 – 1506Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
InParanoidiO70596.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiO70596.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O70596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGNRRRGRF
60 70 80 90 100
VKKDGHCNVR FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL
110 120 130 140 150
LFGLTFWLIA SLHGDLAAPP PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV
160 170 180 190 200
RSVTEECPAA VAAVVLQCIA GCVLDAFVVG AVMAKMAKPK KRNETLVFSE
210 220 230 240 250
NAVVALRDRR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT PEGEYIPLDH
260 270 280 290 300
QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI
310 320 330 340 350
LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT
360 370 380 390 400
YEVPGTPVCS AKELDERAEQ ASHSPKSSFP GSLAAFCYEN ELALSCCQEE
410 420 430
DEEEDTKEGT SAETPDRAAS PQALTPTLAL TLPP
Length:434
Mass (Da):47,609
Last modified:August 1, 1998 - v1
Checksum:iAB586F4628AB42EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003065 mRNA. Translation: CAA05839.1.
RefSeqiNP_733836.1. NM_170718.1.
UniGeneiRn.154434.

Genome annotation databases

EnsembliENSRNOT00000028591; ENSRNOP00000028591; ENSRNOG00000021056.
GeneIDi276720.
KEGGirno:276720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003065 mRNA. Translation: CAA05839.1.
RefSeqiNP_733836.1. NM_170718.1.
UniGeneiRn.154434.

3D structure databases

ProteinModelPortaliO70596.
SMRiO70596. Positions 190-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028591.

Chemistry

GuidetoPHARMACOLOGYi433.

Protein family/group databases

TCDBi1.A.2.1.5. inward rectifier k(+) channel (irk-c) family.

Proteomic databases

PaxDbiO70596.
PRIDEiO70596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028591; ENSRNOP00000028591; ENSRNOG00000021056.
GeneIDi276720.
KEGGirno:276720.

Organism-specific databases

CTDi3770.
RGDi628872. Kcnj14.

Phylogenomic databases

eggNOGiNOG251076.
GeneTreeiENSGT00760000118842.
HOVERGENiHBG006178.
InParanoidiO70596.
KOiK05007.
OMAiPCFSQVA.
OrthoDBiEOG7XPZ5K.
PhylomeDBiO70596.

Enzyme and pathway databases

ReactomeiREACT_199207. Classical Kir channels.

Miscellaneous databases

NextBioi624761.
PROiO70596.

Gene expression databases

GenevestigatoriO70596.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei."
    Toepert C., Doering F., Wischmeyer E., Karschin C., Brockhaus J., Ballanyi K., Derst C., Karschin A.
    J. Neurosci. 18:4096-4105(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiKCJ14_RAT
AccessioniPrimary (citable) accession number: O70596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 1, 1998
Last modified: March 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.