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Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

Abcb6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi623 – 634ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1369007. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Alternative name(s):
Ubiquitously-expressed mammalian ABC half transporter
Gene namesi
Name:Abcb6
Synonyms:Umat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi71077. Abcb6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei186 – 206HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei376 – 396HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei409 – 431HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei500 – 520HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei530 – 550HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686791 – 836ATP-binding cassette sub-family B member 6, mitochondrialAdd BLAST836

Proteomic databases

PaxDbiO70595.
PRIDEiO70595.

PTM databases

PhosphoSitePlusiO70595.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in testis by meiotic pachytene spermatocytes and post-meiotic early spermatids.2 Publications

Gene expression databases

BgeeiENSRNOG00000018697.
ExpressionAtlasiO70595. baseline and differential.
GenevisibleiO70595. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025627.

Structurei

3D structure databases

ProteinModelPortaliO70595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 556ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST292
Domaini590 – 824ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080810.
InParanoidiO70595.
KOiK05661.
OMAiRYQEAII.
OrthoDBiEOG091G02G4.
PhylomeDBiO70595.
TreeFamiTF105194.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR032410. MTABC_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF16185. MTABC_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70595-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVGNYCEA EGPAGPAWTQ NGLSPCFFYT LVPSTLMTLG VLALVLVLPC
60 70 80 90 100
RRREVPAGTE ELSWAAGPRV APYALQLSLA ILQMALPLAS LAGRVGTARG
110 120 130 140 150
VRLPGYLLLA SVLESLASAC GLWLLVVERS QARQSLAMGV WMKFRHSLGL
160 170 180 190 200
LLLWTVTFAA ENLVLVSWNS PQWWWSRADL GQQVQFGLWV LRYMTSGGLF
210 220 230 240 250
ILGLWAPGLR PQSYTLHVNE EDQDGGRNQG RSTDPRSTWR DLGRKLRLLS
260 270 280 290 300
GYLWPRGSPS LQLTVLLCMG LMGLDRALNV LVPIFYRDIV NLLTSKAPWS
310 320 330 340 350
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF
360 370 380 390 400
SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFN IIPTLADIII
410 420 430 440 450
GIIYFSMFFN AWFGLIVFLC MSLYLILTIM VTEWRAKFRR DMNTQENATR
460 470 480 490 500
ARAVDSLLNF ETVKYYNAEG YELERYREAI LKFQGLEWKS TASLVLLNQT
510 520 530 540 550
QNMVIGFGLL AGSLLCAYFV SERRLQVGDF VLFGTYITQL YMPLNWFGTY
560 570 580 590 600
YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRV EFENVHFSYA
610 620 630 640 650
DGRETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID
660 670 680 690 700
GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEIQAAA
710 720 730 740 750
QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL
760 770 780 790 800
DEATSALDTS NERAIQASLA KVCTNRTTIV VAHRLSTVVN ADQILVIKDG
810 820 830
CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEDS
Length:836
Mass (Da):93,305
Last modified:August 1, 1998 - v1
Checksum:i40EC2C32E865522B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003004 mRNA. Translation: CAA05793.1.
BC085712 mRNA. Translation: AAH85712.1.
PIRiJE0248.
RefSeqiNP_542149.1. NM_080582.1.
UniGeneiRn.54408.

Genome annotation databases

EnsembliENSRNOT00000025627; ENSRNOP00000025627; ENSRNOG00000018697.
GeneIDi140669.
KEGGirno:140669.
UCSCiRGD:71077. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003004 mRNA. Translation: CAA05793.1.
BC085712 mRNA. Translation: AAH85712.1.
PIRiJE0248.
RefSeqiNP_542149.1. NM_080582.1.
UniGeneiRn.54408.

3D structure databases

ProteinModelPortaliO70595.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025627.

PTM databases

PhosphoSitePlusiO70595.

Proteomic databases

PaxDbiO70595.
PRIDEiO70595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025627; ENSRNOP00000025627; ENSRNOG00000018697.
GeneIDi140669.
KEGGirno:140669.
UCSCiRGD:71077. rat.

Organism-specific databases

CTDi10058.
RGDi71077. Abcb6.

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080810.
InParanoidiO70595.
KOiK05661.
OMAiRYQEAII.
OrthoDBiEOG091G02G4.
PhylomeDBiO70595.
TreeFamiTF105194.

Enzyme and pathway databases

ReactomeiR-RNO-1369007. Mitochondrial ABC transporters.

Miscellaneous databases

PROiO70595.

Gene expression databases

BgeeiENSRNOG00000018697.
ExpressionAtlasiO70595. baseline and differential.
GenevisibleiO70595. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR032410. MTABC_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF16185. MTABC_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCB6_RAT
AccessioniPrimary (citable) accession number: O70595
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.