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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Small glutamine-rich protein with tetratricopeptide repeats 1
Gene namesi
Name:Sgta
Synonyms:Sgt, Sgt1, Stg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620815. Sgta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Small glutamine-rich tetratricopeptide repeat-containing protein alphaPRO_0000106367Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphothreonineCombined sources
Modified residuei84 – 841PhosphoserineCombined sources
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei302 – 3021PhosphoserineBy similarity
Modified residuei304 – 3041PhosphothreonineBy similarity
Modified residuei306 – 3061PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70593.
PRIDEiO70593.

PTM databases

iPTMnetiO70593.
PhosphoSiteiO70593.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

GenevisibleiO70593. RN.

Interactioni

Subunit structurei

Homooligomerize. Interacts with NS1 from parvovirus H-1. Interacts with DNAJC5 and DNAJC5B (By similarity).By similarity

Protein-protein interaction databases

BioGridi249184. 2 interactions.
STRINGi10116.ENSRNOP00000026960.

Structurei

3D structure databases

ProteinModelPortaliO70593.
SMRiO70593. Positions 86-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 12434TPR 1Add
BLAST
Repeati125 – 15834TPR 2Add
BLAST
Repeati159 – 19234TPR 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 28712Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiO70593.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG78SQJJ.
PhylomeDBiO70593.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRKRLAYA IIQFLHGQLR HGGLSSDAQE SLEVAIQCLE TAFGVTLEDS
60 70 80 90 100
DLALPQTLPE IFEAATASKE MPQDPRGPDR TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKLENFEAA VHLYGKAIEL NPANAVYFCN RAAAYSKLGN YVGAVQDCER
160 170 180 190 200
AIGIDPGYSK AYGRMGLALS SLNKHAEAVA YYKKALELDP DNDTYKSNLK
210 220 230 240 250
IAELKLREAP SPTGGVGSLD IAGLLNNPHF ITMASSLMNS PQLQQLMSGM
260 270 280 290 300
ISGGHNPLGT PGSSPQHSDL ASLIQAGQQF AQQMQQQNPE FVEQIRSQVV
310
RSRTPSASHE EQQE
Length:314
Mass (Da):34,157
Last modified:August 1, 1998 - v1
Checksum:i65EBBE9A773A7F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA. Translation: CAA10960.1.
AF368278 mRNA. Translation: AAP29456.1.
BC087642 mRNA. Translation: AAH87642.1.
RefSeqiNP_073194.1. NM_022703.3.
UniGeneiRn.9655.

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891.
GeneIDi64667.
KEGGirno:64667.
UCSCiRGD:620815. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA. Translation: CAA10960.1.
AF368278 mRNA. Translation: AAP29456.1.
BC087642 mRNA. Translation: AAH87642.1.
RefSeqiNP_073194.1. NM_022703.3.
UniGeneiRn.9655.

3D structure databases

ProteinModelPortaliO70593.
SMRiO70593. Positions 86-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249184. 2 interactions.
STRINGi10116.ENSRNOP00000026960.

PTM databases

iPTMnetiO70593.
PhosphoSiteiO70593.

Proteomic databases

PaxDbiO70593.
PRIDEiO70593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891.
GeneIDi64667.
KEGGirno:64667.
UCSCiRGD:620815. rat.

Organism-specific databases

CTDi6449.
RGDi620815. Sgta.

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiO70593.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG78SQJJ.
PhylomeDBiO70593.

Miscellaneous databases

NextBioi613653.
PROiO70593.

Gene expression databases

GenevisibleiO70593. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1."
    Cziepluch C., Kordes E., Poirey R., Grewenig A., Rommelaere J., Jauniaux J.-C.
    J. Virol. 72:4149-4156(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PARVOVIRUS NS1.
  2. "A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein."
    Tobaben S., Varoqueaux F., Brose N., Stahl B., Meyer G.
    J. Biol. Chem. 278:38376-38383(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Lubec G., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 104-116 AND 165-174, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  5. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-81 AND SER-84, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSGTA_RAT
AccessioniPrimary (citable) accession number: O70593
Secondary accession number(s): Q548F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.