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Protein

Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Gene

Sgta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Alternative name(s):
Alpha-SGT
Small glutamine-rich protein with tetratricopeptide repeats 1
Gene namesi
Name:Sgta
Synonyms:Sgt, Sgt1, Stg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620815. Sgta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063671 – 314Small glutamine-rich tetratricopeptide repeat-containing protein alphaAdd BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphothreonineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei304PhosphothreonineBy similarity1
Modified residuei306PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO70593.
PeptideAtlasiO70593.
PRIDEiO70593.

PTM databases

iPTMnetiO70593.
PhosphoSitePlusiO70593.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSRNOG00000019891.
GenevisibleiO70593. RN.

Interactioni

Subunit structurei

Homooligomerize. Interacts with NS1 from parvovirus H-1. Interacts with DNAJC5 and DNAJC5B (By similarity).By similarity

Protein-protein interaction databases

BioGridi249184. 2 interactors.
STRINGi10116.ENSRNOP00000026960.

Structurei

3D structure databases

ProteinModelPortaliO70593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 124TPR 1Add BLAST34
Repeati125 – 158TPR 2Add BLAST34
Repeati159 – 192TPR 3Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 287Gln-richAdd BLAST12

Sequence similaritiesi

Belongs to the SGT family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiO70593.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG091G0C0Q.
PhylomeDBiO70593.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNRKRLAYA IIQFLHGQLR HGGLSSDAQE SLEVAIQCLE TAFGVTLEDS
60 70 80 90 100
DLALPQTLPE IFEAATASKE MPQDPRGPDR TPPSEEDSAE AERLKTEGNE
110 120 130 140 150
QMKLENFEAA VHLYGKAIEL NPANAVYFCN RAAAYSKLGN YVGAVQDCER
160 170 180 190 200
AIGIDPGYSK AYGRMGLALS SLNKHAEAVA YYKKALELDP DNDTYKSNLK
210 220 230 240 250
IAELKLREAP SPTGGVGSLD IAGLLNNPHF ITMASSLMNS PQLQQLMSGM
260 270 280 290 300
ISGGHNPLGT PGSSPQHSDL ASLIQAGQQF AQQMQQQNPE FVEQIRSQVV
310
RSRTPSASHE EQQE
Length:314
Mass (Da):34,157
Last modified:August 1, 1998 - v1
Checksum:i65EBBE9A773A7F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA. Translation: CAA10960.1.
AF368278 mRNA. Translation: AAP29456.1.
BC087642 mRNA. Translation: AAH87642.1.
RefSeqiNP_073194.1. NM_022703.3.
UniGeneiRn.9655.

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891.
GeneIDi64667.
KEGGirno:64667.
UCSCiRGD:620815. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ222724 mRNA. Translation: CAA10960.1.
AF368278 mRNA. Translation: AAP29456.1.
BC087642 mRNA. Translation: AAH87642.1.
RefSeqiNP_073194.1. NM_022703.3.
UniGeneiRn.9655.

3D structure databases

ProteinModelPortaliO70593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249184. 2 interactors.
STRINGi10116.ENSRNOP00000026960.

PTM databases

iPTMnetiO70593.
PhosphoSitePlusiO70593.

Proteomic databases

PaxDbiO70593.
PeptideAtlasiO70593.
PRIDEiO70593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026960; ENSRNOP00000026960; ENSRNOG00000019891.
GeneIDi64667.
KEGGirno:64667.
UCSCiRGD:620815. rat.

Organism-specific databases

CTDi6449.
RGDi620815. Sgta.

Phylogenomic databases

eggNOGiKOG0553. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110724.
HOGENOMiHOG000208193.
HOVERGENiHBG000885.
InParanoidiO70593.
KOiK16365.
OMAiEAVAYYR.
OrthoDBiEOG091G0C0Q.
PhylomeDBiO70593.

Miscellaneous databases

PROiO70593.

Gene expression databases

BgeeiENSRNOG00000019891.
GenevisibleiO70593. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR032374. SGTA_dimer.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF16546. SGTA_dimer. 1 hit.
PF00515. TPR_1. 2 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGTA_RAT
AccessioniPrimary (citable) accession number: O70593
Secondary accession number(s): Q548F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.