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Protein

Prefoldin subunit 2

Gene

Pfdn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cytoskeleton organization Source: MGI
  • protein folding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:Pfdn2
Synonyms:Pfd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1276111. Pfdn2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • prefoldin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Prefoldin subunit 2PRO_0000124836Add
BLAST

Proteomic databases

EPDiO70591.
MaxQBiO70591.
PaxDbiO70591.
PeptideAtlasiO70591.
PRIDEiO70591.

2D gel databases

REPRODUCTION-2DPAGEIPI00119545.
O70591.

PTM databases

iPTMnetiO70591.
PhosphoSiteiO70591.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006412.
CleanExiMM_PFDN2.
ExpressionAtlasiO70591. baseline and differential.
GenevisibleiO70591. MM.

Interactioni

Subunit structurei

Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202121. 27 interactions.
IntActiO70591. 28 interactions.
MINTiMINT-4584393.
STRINGi10090.ENSMUSP00000120106.

Structurei

3D structure databases

ProteinModelPortaliO70591.
SMRiO70591. Positions 22-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098. Eukaryota.
ENOG4111S6I. LUCA.
GeneTreeiENSGT00390000009272.
HOVERGENiHBG008172.
InParanoidiO70591.
KOiK09549.
OMAiKREYNIR.
OrthoDBiEOG091G11OU.
PhylomeDBiO70591.
TreeFamiTF313252.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

O70591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSGRVGK SGGSGAGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL EGNKEQIQKI
110 120 130 140 150
IETLSQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKASSAG

VLVS
Length:154
Mass (Da):16,534
Last modified:August 13, 2002 - v2
Checksum:iA34F229309AC6715
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 174SGAG → TARW in CAA76760 (PubMed:9630229).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17393 mRNA. Translation: CAA76760.1.
BC026839 mRNA. Translation: AAH26839.1.
BC049606 mRNA. Translation: AAH49606.1.
CCDSiCCDS15491.1.
RefSeqiNP_035200.2. NM_011070.3.
UniGeneiMm.10756.

Genome annotation databases

EnsembliENSMUST00000135941; ENSMUSP00000120106; ENSMUSG00000006412.
GeneIDi18637.
KEGGimmu:18637.
UCSCiuc007doc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17393 mRNA. Translation: CAA76760.1.
BC026839 mRNA. Translation: AAH26839.1.
BC049606 mRNA. Translation: AAH49606.1.
CCDSiCCDS15491.1.
RefSeqiNP_035200.2. NM_011070.3.
UniGeneiMm.10756.

3D structure databases

ProteinModelPortaliO70591.
SMRiO70591. Positions 22-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202121. 27 interactions.
IntActiO70591. 28 interactions.
MINTiMINT-4584393.
STRINGi10090.ENSMUSP00000120106.

PTM databases

iPTMnetiO70591.
PhosphoSiteiO70591.

2D gel databases

REPRODUCTION-2DPAGEIPI00119545.
O70591.

Proteomic databases

EPDiO70591.
MaxQBiO70591.
PaxDbiO70591.
PeptideAtlasiO70591.
PRIDEiO70591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000135941; ENSMUSP00000120106; ENSMUSG00000006412.
GeneIDi18637.
KEGGimmu:18637.
UCSCiuc007doc.1. mouse.

Organism-specific databases

CTDi5202.
MGIiMGI:1276111. Pfdn2.

Phylogenomic databases

eggNOGiKOG4098. Eukaryota.
ENOG4111S6I. LUCA.
GeneTreeiENSGT00390000009272.
HOVERGENiHBG008172.
InParanoidiO70591.
KOiK09549.
OMAiKREYNIR.
OrthoDBiEOG091G11OU.
PhylomeDBiO70591.
TreeFamiTF313252.

Miscellaneous databases

ChiTaRSiPfdn2. mouse.
PROiO70591.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006412.
CleanExiMM_PFDN2.
ExpressionAtlasiO70591. baseline and differential.
GenevisibleiO70591. MM.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR027235. PFD2.
IPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD2_MOUSE
AccessioniPrimary (citable) accession number: O70591
Secondary accession number(s): Q8R0H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 13, 2002
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.