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Protein

Peripheral plasma membrane protein CASK

Gene

Cask

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Note: Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.By similarity

Enzyme regulationi

Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41ATPPROSITE-ProRule annotation1
Active sitei141By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-212676. Dopamine Neurotransmitter Release Cycle.
R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent serine protein kinase
Gene namesi
Name:Cask
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1309489. Cask.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: CACAO
  • basolateral plasma membrane Source: MGI
  • cell-cell junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • cytosol Source: MGI
  • focal adhesion Source: MGI
  • membrane Source: MGI
  • nuclear lamina Source: MGI
  • nuclear matrix Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: BHF-UCL
  • synapse Source: MGI
  • vesicle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000945691 – 926Peripheral plasma membrane protein CASKAdd BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineBy similarity1
Modified residuei151Phosphoserine; by autocatalysisBy similarity1
Modified residuei155Phosphoserine; by autocatalysisBy similarity1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei313PhosphoserineBy similarity1
Isoform 3 (identifier: O70589-3)
Modified residuei570PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70589.
PaxDbiO70589.
PeptideAtlasiO70589.
PRIDEiO70589.

PTM databases

iPTMnetiO70589.
PhosphoSitePlusiO70589.
SwissPalmiO70589.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031012.
ExpressionAtlasiO70589. baseline and differential.
GenevisibleiO70589. MM.

Interactioni

Subunit structurei

Binds WHRN and NRXN1 cytosolic tail. Interacts with CASKIN1, APBA1, LIN7(A/B/C), and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity). CASK and LIN7 form two mutually exclusive tripartite complexes with APBA1 or CASKIN1. Interacts with FCHSD2 (By similarity). Interacts with KIRREL3 (By similarity). Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with TSPYL2. Part of a complex containing CASK, TBR1 and TSPYL2.By similarity3 Publications

GO - Molecular functioni

  • neurexin family protein binding Source: MGI

Protein-protein interaction databases

BioGridi198491. 8 interactors.
IntActiO70589. 18 interactors.
MINTiMINT-4092125.
STRINGi10090.ENSMUSP00000111096.

Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi406 – 417Combined sources12
Helixi423 – 433Combined sources11
Helixi435 – 452Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y74NMR-B/D405-454[»]
ProteinModelPortaliO70589.
SMRiO70589.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini343 – 398L27 1PROSITE-ProRule annotationAdd BLAST56
Domaini402 – 455L27 2PROSITE-ProRule annotationAdd BLAST54
Domaini490 – 571PDZPROSITE-ProRule annotationAdd BLAST82
Domaini612 – 682SH3PROSITE-ProRule annotationAdd BLAST71
Domaini739 – 911Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni305 – 315Calmodulin-bindingAdd BLAST11

Domaini

The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
The protein kinase domain mediates the interaction with FCHSD2.By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
KOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiO70589.
KOiK06103.
OMAiLVCTASQ.
OrthoDBiEOG091G065I.
PhylomeDBiO70589.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O70589-1) [UniParc]FASTAAdd to basket
Also known as: CASK-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
60 70 80 90 100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
110 120 130 140 150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
160 170 180 190 200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
210 220 230 240 250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
260 270 280 290 300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
310 320 330 340 350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV
360 370 380 390 400
LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN
410 420 430 440 450
PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE
460 470 480 490 500
VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP
510 520 530 540 550
MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE
560 570 580 590 600
QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS
610 620 630 640 650
VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS
660 670 680 690 700
KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW
710 720 730 740 750
FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV
760 770 780 790 800
GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI
810 820 830 840 850
SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF
860 870 880 890 900
APFVVFIAAP TITPGLNEDE SLQRLQKESD VLQRTYAHYF DLTIINNEID
910 920
ETIRHLEEAV ELVCTAPQWV PVSWVY
Length:926
Mass (Da):105,109
Last modified:April 17, 2007 - v2
Checksum:iADD2008CE53E0018
GO
Isoform 2 (identifier: O70589-2) [UniParc]FASTAAdd to basket
Also known as: CASK-A

The sequence of this isoform differs from the canonical sequence as follows:
     580-664: RDSPSTSRQS...NWWQGKLENS → VISLTSLSYP...KIKAKYRKLQ
     665-926: Missing.

Show »
Length:664
Mass (Da):74,907
Checksum:iB60B1EB9E3091CB6
GO
Isoform 3 (identifier: O70589-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     580-602: Missing.

Show »
Length:897
Mass (Da):102,100
Checksum:i4AEBC03D2EEE3F68
GO
Isoform 4 (identifier: O70589-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     603-614: Missing.

Show »
Length:908
Mass (Da):103,145
Checksum:i0413DFBEA74F4E37
GO
Isoform 5 (identifier: O70589-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.

Show »
Length:920
Mass (Da):104,455
Checksum:iDD0E0B86503865A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298F → L in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti298F → L in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti666N → K in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti666N → K in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti677 – 679LQE → IQG in CAA76646 (PubMed:9787075).Curated3
Sequence conflicti677 – 679LQE → IQG in CAA76647 (PubMed:9787075).Curated3
Sequence conflicti720 – 723FDQL → LII in CAA76646 (PubMed:9787075).Curated4
Sequence conflicti720 – 723FDQL → LII in CAA76647 (PubMed:9787075).Curated4
Sequence conflicti742L → S in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti742L → S in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti769Y → C in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti769Y → C in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti798Q → R in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti798Q → R in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti816Y → F in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti816Y → F in CAA76647 (PubMed:9787075).Curated1
Sequence conflicti821 – 823ETI → DH in CAA76646 (PubMed:9787075).Curated3
Sequence conflicti821 – 823ETI → DH in CAA76647 (PubMed:9787075).Curated3
Sequence conflicti851A → P in CAA76646 (PubMed:9787075).Curated1
Sequence conflicti851A → P in CAA76647 (PubMed:9787075).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024614340 – 345Missing in isoform 3, isoform 4 and isoform 5. 1 Publication6
Alternative sequenceiVSP_003152580 – 664RDSPS…KLENS → VISLTSLSYPNLPISSEFLT NFLLMAECFCFLGNCFCCAV TTLHTNFTTKITEQKEVPPT SSALLACRYLQPFCSKIKAK YRKLQ in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_024615580 – 602Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_024616603 – 614Missing in isoform 4. CuratedAdd BLAST12
Alternative sequenceiVSP_003153665 – 926Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17138 mRNA. Translation: CAA76647.1.
Y17137 mRNA. Translation: CAA76646.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19440.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19441.1.
AL671117, AL672204 Genomic DNA. Translation: CAM19446.1.
AL672204, AL671117, BX005215 Genomic DNA. Translation: CAM20906.1.
AL672204, BX005215, AL671117 Genomic DNA. Translation: CAM20907.1.
AL672204, AL671117 Genomic DNA. Translation: CAM20909.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19528.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19529.1.
AK136523 mRNA. Translation: BAE23024.1.
CCDSiCCDS40878.1. [O70589-3]
CCDS72343.1. [O70589-5]
RefSeqiNP_001271432.1. NM_001284503.1. [O70589-1]
NP_001271433.1. NM_001284504.1.
NP_001271434.1. NM_001284505.1. [O70589-5]
NP_033936.2. NM_009806.3. [O70589-3]
UniGeneiMm.327591.
Mm.474948.

Genome annotation databases

EnsembliENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012. [O70589-4]
ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012. [O70589-3]
ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012. [O70589-5]
GeneIDi12361.
KEGGimmu:12361.
UCSCiuc009srp.2. mouse. [O70589-3]
uc009srq.2. mouse. [O70589-1]
uc012hez.2. mouse. [O70589-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17138 mRNA. Translation: CAA76647.1.
Y17137 mRNA. Translation: CAA76646.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19440.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19441.1.
AL671117, AL672204 Genomic DNA. Translation: CAM19446.1.
AL672204, AL671117, BX005215 Genomic DNA. Translation: CAM20906.1.
AL672204, BX005215, AL671117 Genomic DNA. Translation: CAM20907.1.
AL672204, AL671117 Genomic DNA. Translation: CAM20909.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19528.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19529.1.
AK136523 mRNA. Translation: BAE23024.1.
CCDSiCCDS40878.1. [O70589-3]
CCDS72343.1. [O70589-5]
RefSeqiNP_001271432.1. NM_001284503.1. [O70589-1]
NP_001271433.1. NM_001284504.1.
NP_001271434.1. NM_001284505.1. [O70589-5]
NP_033936.2. NM_009806.3. [O70589-3]
UniGeneiMm.327591.
Mm.474948.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y74NMR-B/D405-454[»]
ProteinModelPortaliO70589.
SMRiO70589.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198491. 8 interactors.
IntActiO70589. 18 interactors.
MINTiMINT-4092125.
STRINGi10090.ENSMUSP00000111096.

PTM databases

iPTMnetiO70589.
PhosphoSitePlusiO70589.
SwissPalmiO70589.

Proteomic databases

MaxQBiO70589.
PaxDbiO70589.
PeptideAtlasiO70589.
PRIDEiO70589.

Protocols and materials databases

DNASUi12361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012. [O70589-4]
ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012. [O70589-3]
ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012. [O70589-5]
GeneIDi12361.
KEGGimmu:12361.
UCSCiuc009srp.2. mouse. [O70589-3]
uc009srq.2. mouse. [O70589-1]
uc012hez.2. mouse. [O70589-5]

Organism-specific databases

CTDi8573.
MGIiMGI:1309489. Cask.

Phylogenomic databases

eggNOGiKOG0033. Eukaryota.
KOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiO70589.
KOiK06103.
OMAiLVCTASQ.
OrthoDBiEOG091G065I.
PhylomeDBiO70589.
TreeFamiTF314263.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiR-MMU-212676. Dopamine Neurotransmitter Release Cycle.
R-MMU-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiCask. mouse.
EvolutionaryTraceiO70589.
PROiO70589.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031012.
ExpressionAtlasiO70589. baseline and differential.
GenevisibleiO70589. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 2 hits.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSKP_MOUSE
AccessioniPrimary (citable) accession number: O70589
Secondary accession number(s): A2ADP8
, A2ADP9, A2ADQ4, O70588, Q3UW92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.