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O70589

- CSKP_MOUSE

UniProt

O70589 - CSKP_MOUSE

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Protein

Peripheral plasma membrane protein CASK

Gene

Cask

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.By similarity

Enzyme regulationi

Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411ATPPROSITE-ProRule annotation
Active sitei141 – 1411By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. neurexin family protein binding Source: MGI
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion import Source: MGI
  2. negative regulation of cell-matrix adhesion Source: Ensembl
  3. negative regulation of cellular response to growth factor stimulus Source: Ensembl
  4. negative regulation of keratinocyte proliferation Source: Ensembl
  5. negative regulation of wound healing Source: Ensembl
  6. positive regulation of calcium ion import Source: MGI
  7. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.
ReactomeiREACT_196644. Syndecan interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.1)
Alternative name(s):
Calcium/calmodulin-dependent serine protein kinase
Gene namesi
Name:Cask
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1309489. Cask.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. basolateral plasma membrane Source: MGI
  3. cell-cell junction Source: BHF-UCL
  4. cytoplasm Source: BHF-UCL
  5. cytosol Source: MGI
  6. membrane Source: MGI
  7. nuclear lamina Source: Ensembl
  8. nuclear matrix Source: Ensembl
  9. nucleolus Source: Ensembl
  10. nucleus Source: BHF-UCL
  11. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 926926Peripheral plasma membrane protein CASKPRO_0000094569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine; by autocatalysisBy similarity
Modified residuei155 – 1551Phosphoserine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70589.
PaxDbiO70589.
PRIDEiO70589.

PTM databases

PhosphoSiteiO70589.

Expressioni

Gene expression databases

BgeeiO70589.
ExpressionAtlasiO70589. baseline and differential.
GenevestigatoriO70589.

Interactioni

Subunit structurei

Binds WHRN and NRXN1 cytosolic tail. Interacts with CASKIN1, APBA1, LIN7(A/B/C), and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity). CASK and LIN7 form two mutually exclusive tripartite complexes with APBA1 or CASKIN1. Interacts with FCHSD2 (By similarity). Interacts with KIRREL3 (By similarity). Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with TSPYL2. Part of a complex containing CASK, TBR1 and TSPYL2.By similarity3 Publications

Protein-protein interaction databases

BioGridi198491. 4 interactions.
IntActiO70589. 18 interactions.
MINTiMINT-4092125.

Structurei

Secondary structure

1
926
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi406 – 41712
Helixi423 – 43311
Helixi435 – 45218

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y74NMR-B/D405-454[»]
ProteinModelPortaliO70589.
SMRiO70589. Positions 5-394, 403-456, 487-572, 615-921.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO70589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 276265Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini343 – 39856L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini402 – 45554L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini490 – 57182PDZPROSITE-ProRule annotationAdd
BLAST
Domaini612 – 68271SH3PROSITE-ProRule annotationAdd
BLAST
Domaini739 – 911173Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni305 – 31511Calmodulin-bindingAdd
BLAST

Domaini

The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
The protein kinase domain mediates the interaction with FCHSD2.By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiO70589.
KOiK06103.
OMAiRCINRET.
OrthoDBiEOG79CXZ5.
PhylomeDBiO70589.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O70589-1) [UniParc]FASTAAdd to Basket

Also known as: CASK-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
60 70 80 90 100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
110 120 130 140 150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
160 170 180 190 200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
210 220 230 240 250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
260 270 280 290 300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
310 320 330 340 350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV
360 370 380 390 400
LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN
410 420 430 440 450
PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE
460 470 480 490 500
VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP
510 520 530 540 550
MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE
560 570 580 590 600
QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS
610 620 630 640 650
VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS
660 670 680 690 700
KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW
710 720 730 740 750
FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV
760 770 780 790 800
GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI
810 820 830 840 850
SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF
860 870 880 890 900
APFVVFIAAP TITPGLNEDE SLQRLQKESD VLQRTYAHYF DLTIINNEID
910 920
ETIRHLEEAV ELVCTAPQWV PVSWVY
Length:926
Mass (Da):105,109
Last modified:April 17, 2007 - v2
Checksum:iADD2008CE53E0018
GO
Isoform 2 (identifier: O70589-2) [UniParc]FASTAAdd to Basket

Also known as: CASK-A

The sequence of this isoform differs from the canonical sequence as follows:
     580-664: RDSPSTSRQS...NWWQGKLENS → VISLTSLSYP...KIKAKYRKLQ
     665-926: Missing.

Show »
Length:664
Mass (Da):74,907
Checksum:iB60B1EB9E3091CB6
GO
Isoform 3 (identifier: O70589-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     580-602: Missing.

Show »
Length:897
Mass (Da):102,100
Checksum:i4AEBC03D2EEE3F68
GO
Isoform 4 (identifier: O70589-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     603-614: Missing.

Show »
Length:908
Mass (Da):103,145
Checksum:i0413DFBEA74F4E37
GO
Isoform 5 (identifier: O70589-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.

Show »
Length:920
Mass (Da):104,455
Checksum:iDD0E0B86503865A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981F → L in CAA76646. (PubMed:9787075)Curated
Sequence conflicti298 – 2981F → L in CAA76647. (PubMed:9787075)Curated
Sequence conflicti666 – 6661N → K in CAA76646. (PubMed:9787075)Curated
Sequence conflicti666 – 6661N → K in CAA76647. (PubMed:9787075)Curated
Sequence conflicti677 – 6793LQE → IQG in CAA76646. (PubMed:9787075)Curated
Sequence conflicti677 – 6793LQE → IQG in CAA76647. (PubMed:9787075)Curated
Sequence conflicti720 – 7234FDQL → LII in CAA76646. (PubMed:9787075)Curated
Sequence conflicti720 – 7234FDQL → LII in CAA76647. (PubMed:9787075)Curated
Sequence conflicti742 – 7421L → S in CAA76646. (PubMed:9787075)Curated
Sequence conflicti742 – 7421L → S in CAA76647. (PubMed:9787075)Curated
Sequence conflicti769 – 7691Y → C in CAA76646. (PubMed:9787075)Curated
Sequence conflicti769 – 7691Y → C in CAA76647. (PubMed:9787075)Curated
Sequence conflicti798 – 7981Q → R in CAA76646. (PubMed:9787075)Curated
Sequence conflicti798 – 7981Q → R in CAA76647. (PubMed:9787075)Curated
Sequence conflicti816 – 8161Y → F in CAA76646. (PubMed:9787075)Curated
Sequence conflicti816 – 8161Y → F in CAA76647. (PubMed:9787075)Curated
Sequence conflicti821 – 8233ETI → DH in CAA76646. (PubMed:9787075)Curated
Sequence conflicti821 – 8233ETI → DH in CAA76647. (PubMed:9787075)Curated
Sequence conflicti851 – 8511A → P in CAA76646. (PubMed:9787075)Curated
Sequence conflicti851 – 8511A → P in CAA76647. (PubMed:9787075)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei340 – 3456Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_024614
Alternative sequencei580 – 66485RDSPS…KLENS → VISLTSLSYPNLPISSEFLT NFLLMAECFCFLGNCFCCAV TTLHTNFTTKITEQKEVPPT SSALLACRYLQPFCSKIKAK YRKLQ in isoform 2. 1 PublicationVSP_003152Add
BLAST
Alternative sequencei580 – 60223Missing in isoform 3. 1 PublicationVSP_024615Add
BLAST
Alternative sequencei603 – 61412Missing in isoform 4. CuratedVSP_024616Add
BLAST
Alternative sequencei665 – 926262Missing in isoform 2. 1 PublicationVSP_003153Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17138 mRNA. Translation: CAA76647.1.
Y17137 mRNA. Translation: CAA76646.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19440.1.
AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19441.1.
AL671117, AL672204 Genomic DNA. Translation: CAM19446.1.
AL672204, AL671117, BX005215 Genomic DNA. Translation: CAM20906.1.
AL672204, BX005215, AL671117 Genomic DNA. Translation: CAM20907.1.
AL672204, AL671117 Genomic DNA. Translation: CAM20909.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19528.1.
BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19529.1.
AK136523 mRNA. Translation: BAE23024.1.
CCDSiCCDS40878.1. [O70589-3]
CCDS72343.1. [O70589-5]
RefSeqiNP_001271432.1. NM_001284503.1. [O70589-1]
NP_001271433.1. NM_001284504.1.
NP_001271434.1. NM_001284505.1. [O70589-5]
NP_033936.2. NM_009806.3. [O70589-3]
UniGeneiMm.327591.
Mm.474948.

Genome annotation databases

EnsembliENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012. [O70589-4]
ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012. [O70589-3]
ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012. [O70589-5]
GeneIDi12361.
KEGGimmu:12361.
UCSCiuc009srp.1. mouse. [O70589-3]
uc009srq.1. mouse. [O70589-1]
uc012hez.1. mouse. [O70589-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17138 mRNA. Translation: CAA76647.1 .
Y17137 mRNA. Translation: CAA76646.1 .
AL671117 , AL672204 , BX005215 Genomic DNA. Translation: CAM19440.1 .
AL671117 , AL672204 , BX005215 Genomic DNA. Translation: CAM19441.1 .
AL671117 , AL672204 Genomic DNA. Translation: CAM19446.1 .
AL672204 , AL671117 , BX005215 Genomic DNA. Translation: CAM20906.1 .
AL672204 , BX005215 , AL671117 Genomic DNA. Translation: CAM20907.1 .
AL672204 , AL671117 Genomic DNA. Translation: CAM20909.1 .
BX005215 , AL672204 , AL671117 Genomic DNA. Translation: CAM19528.1 .
BX005215 , AL672204 , AL671117 Genomic DNA. Translation: CAM19529.1 .
AK136523 mRNA. Translation: BAE23024.1 .
CCDSi CCDS40878.1. [O70589-3 ]
CCDS72343.1. [O70589-5 ]
RefSeqi NP_001271432.1. NM_001284503.1. [O70589-1 ]
NP_001271433.1. NM_001284504.1.
NP_001271434.1. NM_001284505.1. [O70589-5 ]
NP_033936.2. NM_009806.3. [O70589-3 ]
UniGenei Mm.327591.
Mm.474948.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1Y74 NMR - B/D 405-454 [» ]
ProteinModelPortali O70589.
SMRi O70589. Positions 5-394, 403-456, 487-572, 615-921.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198491. 4 interactions.
IntActi O70589. 18 interactions.
MINTi MINT-4092125.

PTM databases

PhosphoSitei O70589.

Proteomic databases

MaxQBi O70589.
PaxDbi O70589.
PRIDEi O70589.

Protocols and materials databases

DNASUi 12361.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033321 ; ENSMUSP00000033321 ; ENSMUSG00000031012 . [O70589-4 ]
ENSMUST00000115436 ; ENSMUSP00000111096 ; ENSMUSG00000031012 . [O70589-3 ]
ENSMUST00000115438 ; ENSMUSP00000111098 ; ENSMUSG00000031012 . [O70589-5 ]
GeneIDi 12361.
KEGGi mmu:12361.
UCSCi uc009srp.1. mouse. [O70589-3 ]
uc009srq.1. mouse. [O70589-1 ]
uc012hez.1. mouse. [O70589-5 ]

Organism-specific databases

CTDi 8573.
MGIi MGI:1309489. Cask.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118866.
HOGENOMi HOG000233034.
HOVERGENi HBG001858.
InParanoidi O70589.
KOi K06103.
OMAi RCINRET.
OrthoDBi EOG79CXZ5.
PhylomeDBi O70589.
TreeFami TF314263.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 3474.
Reactomei REACT_196644. Syndecan interactions.

Miscellaneous databases

ChiTaRSi CASK. mouse.
EvolutionaryTracei O70589.
NextBioi 281028.
PROi O70589.
SOURCEi Search...

Gene expression databases

Bgeei O70589.
ExpressionAtlasi O70589. baseline and differential.
Genevestigatori O70589.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR011009. Kinase-like_dom.
IPR004172. L27.
IPR014775. L27_C.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF00069. Pkinase. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00220. S_TKc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine CASK is disrupted in a sex-linked cleft palate mouse mutant."
    Laverty H.G., Wilson J.B.
    Genomics 53:29-41(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-926 (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Cecum.
  4. "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2."
    Hsueh Y.P., Wang T.F., Yang F.C., Sheng M.
    Nature 404:298-302(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TBR1.
  5. "Transcriptional modification by a CASK-interacting nucleosome assembly protein."
    Wang G.-S., Hong C.-J., Yen T.-Y., Huang H.-Y., Ou Y., Huang T.-N., Jung W.-G., Kuo T.-Y., Sheng M., Wang T.-F., Hsueh Y.-P.
    Neuron 42:113-128(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSPYL2, IDENTIFICATION IN COMPLEX WITH TSPYL2 AND TBR1.
    Strain: C57BL/6.
  6. "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins."
    Feng W., Long J.-F., Zhang M.
    Proc. Natl. Acad. Sci. U.S.A. 102:6861-6866(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 405-454, INTERACTION WITH LIN7B.

Entry informationi

Entry nameiCSKP_MOUSE
AccessioniPrimary (citable) accession number: O70589
Secondary accession number(s): A2ADP8
, A2ADP9, A2ADQ4, O70588, Q3UW92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3