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O70589

- CSKP_MOUSE

UniProt

O70589 - CSKP_MOUSE

Protein

Peripheral plasma membrane protein CASK

Gene

Cask

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (17 Apr 2007)
      Previous versions | rss
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    Functioni

    Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.By similarity

    Enzyme regulationi

    Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411ATPPROSITE-ProRule annotation
    Active sitei141 – 1411By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 269ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. neurexin family protein binding Source: MGI
    3. protein binding Source: MGI
    4. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion import Source: MGI
    2. negative regulation of cell-matrix adhesion Source: Ensembl
    3. negative regulation of cellular response to growth factor stimulus Source: Ensembl
    4. negative regulation of keratinocyte proliferation Source: Ensembl
    5. negative regulation of wound healing Source: Ensembl
    6. positive regulation of calcium ion import Source: MGI
    7. positive regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 3474.
    ReactomeiREACT_196644. Syndecan interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peripheral plasma membrane protein CASK (EC:2.7.11.1)
    Alternative name(s):
    Calcium/calmodulin-dependent serine protein kinase
    Gene namesi
    Name:Cask
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1309489. Cask.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. basolateral plasma membrane Source: MGI
    3. cell-cell junction Source: BHF-UCL
    4. cytoplasm Source: BHF-UCL
    5. cytosol Source: MGI
    6. membrane Source: MGI
    7. nuclear lamina Source: Ensembl
    8. nuclear matrix Source: Ensembl
    9. nucleolus Source: Ensembl
    10. nucleus Source: BHF-UCL
    11. synapse Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 926926Peripheral plasma membrane protein CASKPRO_0000094569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511Phosphoserine; by autocatalysisBy similarity
    Modified residuei155 – 1551Phosphoserine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO70589.
    PaxDbiO70589.
    PRIDEiO70589.

    PTM databases

    PhosphoSiteiO70589.

    Expressioni

    Gene expression databases

    ArrayExpressiO70589.
    BgeeiO70589.
    GenevestigatoriO70589.

    Interactioni

    Subunit structurei

    Binds WHRN and NRXN1 cytosolic tail. Interacts with CASKIN1, APBA1, LIN7(A/B/C), and L27 domain of DLG1 and isoform 2 of DLG4 By similarity. CASK and LIN7 form two mutually exclusive tripartite complexes with APBA1 or CASKIN1. Interacts with FCHSD2 By similarity. Interacts with KIRREL3 By similarity. Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 By similarity. Interacts with TSPYL2. Part of a complex containing CASK, TBR1 and TSPYL2.By similarity3 Publications

    Protein-protein interaction databases

    BioGridi198491. 4 interactions.
    IntActiO70589. 18 interactions.
    MINTiMINT-4092125.

    Structurei

    Secondary structure

    1
    926
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi406 – 41712
    Helixi423 – 43311
    Helixi435 – 45218

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y74NMR-B/D405-454[»]
    ProteinModelPortaliO70589.
    SMRiO70589. Positions 5-394, 403-456, 487-572, 615-921.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO70589.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 276265Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini343 – 39856L27 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini402 – 45554L27 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini490 – 57182PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini612 – 68271SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini739 – 911173Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni305 – 31511Calmodulin-bindingAdd
    BLAST

    Domaini

    The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
    The protein kinase domain mediates the interaction with FCHSD2.By similarity

    Sequence similaritiesi

    In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 2 L27 domains.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000077048.
    HOGENOMiHOG000233034.
    HOVERGENiHBG001858.
    InParanoidiO70589.
    KOiK06103.
    OMAiRCINRET.
    OrthoDBiEOG79CXZ5.
    PhylomeDBiO70589.
    TreeFamiTF314263.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR011009. Kinase-like_dom.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00220. S_TKc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O70589-1) [UniParc]FASTAAdd to Basket

    Also known as: CASK-B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS    50
    SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC 100
    FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA 150
    SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV 200
    DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK 250
    DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300
    RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV 350
    LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN 400
    PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE 450
    VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP 500
    MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE 550
    QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS 600
    VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS 650
    KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW 700
    FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV 750
    GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI 800
    SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF 850
    APFVVFIAAP TITPGLNEDE SLQRLQKESD VLQRTYAHYF DLTIINNEID 900
    ETIRHLEEAV ELVCTAPQWV PVSWVY 926
    Length:926
    Mass (Da):105,109
    Last modified:April 17, 2007 - v2
    Checksum:iADD2008CE53E0018
    GO
    Isoform 2 (identifier: O70589-2) [UniParc]FASTAAdd to Basket

    Also known as: CASK-A

    The sequence of this isoform differs from the canonical sequence as follows:
         580-664: RDSPSTSRQS...NWWQGKLENS → VISLTSLSYP...KIKAKYRKLQ
         665-926: Missing.

    Show »
    Length:664
    Mass (Da):74,907
    Checksum:iB60B1EB9E3091CB6
    GO
    Isoform 3 (identifier: O70589-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-345: Missing.
         580-602: Missing.

    Show »
    Length:897
    Mass (Da):102,100
    Checksum:i4AEBC03D2EEE3F68
    GO
    Isoform 4 (identifier: O70589-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-345: Missing.
         603-614: Missing.

    Show »
    Length:908
    Mass (Da):103,145
    Checksum:i0413DFBEA74F4E37
    GO
    Isoform 5 (identifier: O70589-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-345: Missing.

    Show »
    Length:920
    Mass (Da):104,455
    Checksum:iDD0E0B86503865A6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti298 – 2981F → L in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti298 – 2981F → L in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti666 – 6661N → K in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti666 – 6661N → K in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti677 – 6793LQE → IQG in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti677 – 6793LQE → IQG in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti720 – 7234FDQL → LII in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti720 – 7234FDQL → LII in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti742 – 7421L → S in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti742 – 7421L → S in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti769 – 7691Y → C in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti769 – 7691Y → C in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti798 – 7981Q → R in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti798 – 7981Q → R in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti816 – 8161Y → F in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti816 – 8161Y → F in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti821 – 8233ETI → DH in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti821 – 8233ETI → DH in CAA76647. (PubMed:9787075)Curated
    Sequence conflicti851 – 8511A → P in CAA76646. (PubMed:9787075)Curated
    Sequence conflicti851 – 8511A → P in CAA76647. (PubMed:9787075)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei340 – 3456Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationVSP_024614
    Alternative sequencei580 – 66485RDSPS…KLENS → VISLTSLSYPNLPISSEFLT NFLLMAECFCFLGNCFCCAV TTLHTNFTTKITEQKEVPPT SSALLACRYLQPFCSKIKAK YRKLQ in isoform 2. 1 PublicationVSP_003152Add
    BLAST
    Alternative sequencei580 – 60223Missing in isoform 3. 1 PublicationVSP_024615Add
    BLAST
    Alternative sequencei603 – 61412Missing in isoform 4. CuratedVSP_024616Add
    BLAST
    Alternative sequencei665 – 926262Missing in isoform 2. 1 PublicationVSP_003153Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17138 mRNA. Translation: CAA76647.1.
    Y17137 mRNA. Translation: CAA76646.1.
    AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19440.1.
    AL671117, AL672204, BX005215 Genomic DNA. Translation: CAM19441.1.
    AL671117, AL672204 Genomic DNA. Translation: CAM19446.1.
    AL672204, AL671117, BX005215 Genomic DNA. Translation: CAM20906.1.
    AL672204, BX005215, AL671117 Genomic DNA. Translation: CAM20907.1.
    AL672204, AL671117 Genomic DNA. Translation: CAM20909.1.
    BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19528.1.
    BX005215, AL672204, AL671117 Genomic DNA. Translation: CAM19529.1.
    AK136523 mRNA. Translation: BAE23024.1.
    CCDSiCCDS40878.1. [O70589-3]
    CCDS72343.1. [O70589-5]
    RefSeqiNP_001271432.1. NM_001284503.1. [O70589-1]
    NP_001271433.1. NM_001284504.1.
    NP_001271434.1. NM_001284505.1. [O70589-5]
    NP_033936.2. NM_009806.3. [O70589-3]
    UniGeneiMm.327591.
    Mm.474948.

    Genome annotation databases

    EnsembliENSMUST00000033321; ENSMUSP00000033321; ENSMUSG00000031012. [O70589-4]
    ENSMUST00000115436; ENSMUSP00000111096; ENSMUSG00000031012. [O70589-3]
    ENSMUST00000115438; ENSMUSP00000111098; ENSMUSG00000031012. [O70589-5]
    GeneIDi12361.
    KEGGimmu:12361.
    UCSCiuc009srp.1. mouse. [O70589-3]
    uc009srq.1. mouse. [O70589-1]
    uc012hez.1. mouse. [O70589-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17138 mRNA. Translation: CAA76647.1 .
    Y17137 mRNA. Translation: CAA76646.1 .
    AL671117 , AL672204 , BX005215 Genomic DNA. Translation: CAM19440.1 .
    AL671117 , AL672204 , BX005215 Genomic DNA. Translation: CAM19441.1 .
    AL671117 , AL672204 Genomic DNA. Translation: CAM19446.1 .
    AL672204 , AL671117 , BX005215 Genomic DNA. Translation: CAM20906.1 .
    AL672204 , BX005215 , AL671117 Genomic DNA. Translation: CAM20907.1 .
    AL672204 , AL671117 Genomic DNA. Translation: CAM20909.1 .
    BX005215 , AL672204 , AL671117 Genomic DNA. Translation: CAM19528.1 .
    BX005215 , AL672204 , AL671117 Genomic DNA. Translation: CAM19529.1 .
    AK136523 mRNA. Translation: BAE23024.1 .
    CCDSi CCDS40878.1. [O70589-3 ]
    CCDS72343.1. [O70589-5 ]
    RefSeqi NP_001271432.1. NM_001284503.1. [O70589-1 ]
    NP_001271433.1. NM_001284504.1.
    NP_001271434.1. NM_001284505.1. [O70589-5 ]
    NP_033936.2. NM_009806.3. [O70589-3 ]
    UniGenei Mm.327591.
    Mm.474948.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Y74 NMR - B/D 405-454 [» ]
    ProteinModelPortali O70589.
    SMRi O70589. Positions 5-394, 403-456, 487-572, 615-921.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198491. 4 interactions.
    IntActi O70589. 18 interactions.
    MINTi MINT-4092125.

    PTM databases

    PhosphoSitei O70589.

    Proteomic databases

    MaxQBi O70589.
    PaxDbi O70589.
    PRIDEi O70589.

    Protocols and materials databases

    DNASUi 12361.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033321 ; ENSMUSP00000033321 ; ENSMUSG00000031012 . [O70589-4 ]
    ENSMUST00000115436 ; ENSMUSP00000111096 ; ENSMUSG00000031012 . [O70589-3 ]
    ENSMUST00000115438 ; ENSMUSP00000111098 ; ENSMUSG00000031012 . [O70589-5 ]
    GeneIDi 12361.
    KEGGi mmu:12361.
    UCSCi uc009srp.1. mouse. [O70589-3 ]
    uc009srq.1. mouse. [O70589-1 ]
    uc012hez.1. mouse. [O70589-5 ]

    Organism-specific databases

    CTDi 8573.
    MGIi MGI:1309489. Cask.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000077048.
    HOGENOMi HOG000233034.
    HOVERGENi HBG001858.
    InParanoidi O70589.
    KOi K06103.
    OMAi RCINRET.
    OrthoDBi EOG79CXZ5.
    PhylomeDBi O70589.
    TreeFami TF314263.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 3474.
    Reactomei REACT_196644. Syndecan interactions.

    Miscellaneous databases

    ChiTaRSi CASK. mouse.
    EvolutionaryTracei O70589.
    NextBioi 281028.
    PROi O70589.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70589.
    Bgeei O70589.
    Genevestigatori O70589.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR011009. Kinase-like_dom.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 2 hits.
    PF00595. PDZ. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00220. S_TKc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine CASK is disrupted in a sex-linked cleft palate mouse mutant."
      Laverty H.G., Wilson J.B.
      Genomics 53:29-41(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-926 (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Cecum.
    4. "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2."
      Hsueh Y.P., Wang T.F., Yang F.C., Sheng M.
      Nature 404:298-302(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TBR1.
    5. "Transcriptional modification by a CASK-interacting nucleosome assembly protein."
      Wang G.-S., Hong C.-J., Yen T.-Y., Huang H.-Y., Ou Y., Huang T.-N., Jung W.-G., Kuo T.-Y., Sheng M., Wang T.-F., Hsueh Y.-P.
      Neuron 42:113-128(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TSPYL2, IDENTIFICATION IN COMPLEX WITH TSPYL2 AND TBR1.
      Strain: C57BL/6.
    6. "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins."
      Feng W., Long J.-F., Zhang M.
      Proc. Natl. Acad. Sci. U.S.A. 102:6861-6866(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 405-454, INTERACTION WITH LIN7B.

    Entry informationi

    Entry nameiCSKP_MOUSE
    AccessioniPrimary (citable) accession number: O70589
    Secondary accession number(s): A2ADP8
    , A2ADP9, A2ADQ4, O70588, Q3UW92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 17, 2007
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3