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O70585

- DTNB_MOUSE

UniProt

O70585 - DTNB_MOUSE

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Protein

Dystrobrevin beta

Gene

Dtnb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrobrevin beta
Short name:
DTN-B
Short name:
mDTN-B
Alternative name(s):
Beta-dystrobrevin
Gene namesi
Name:Dtnb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1203728. Dtnb.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 659659Dystrobrevin betaPRO_0000086879Add
BLAST

Proteomic databases

MaxQBiO70585.
PaxDbiO70585.
PRIDEiO70585.

PTM databases

PhosphoSiteiO70585.

Expressioni

Tissue specificityi

Expressed mainly in brain, kidney, liver and lung. In brain expressed in neurons of the cortex and hippocampus.

Gene expression databases

BgeeiO70585.
CleanExiMM_DTNB.
ExpressionAtlasiO70585. baseline and differential.
GenevestigatoriO70585.

Interactioni

Subunit structurei

Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (By similarity). Binds dystrobrevin binding protein 1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kif5aP331754EBI-349714,EBI-349710

Protein-protein interaction databases

IntActiO70585. 7 interactions.
MINTiMINT-197260.

Structurei

3D structure databases

ProteinModelPortaliO70585.
SMRiO70585. Positions 26-235, 237-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni369 – 41850Syntrophin-binding regionAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili429 – 51991Sequence AnalysisAdd
BLAST

Domaini

The coiled coil domain may mediate the interaction with dystrophin.

Sequence similaritiesi

Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG251970.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000230684.
HOVERGENiHBG005539.
InParanoidiO70585.
OMAiLEEENSM.
TreeFamiTF343849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038204. Distrobrevin. 1 hit.
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O70585-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEEGGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL
60 70 80 90 100
HLVDIWNMIE AFRDNGLNTL DHSTEISVSR LETVISSIYY QLNKRLPSTH
110 120 130 140 150
QISVEQSISL LLNFMVAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY
160 170 180 190 200
IFSQMSDSNG LMMFGKLDQF LKEALKLPTA VFEGPSFGYT EHAVRTCFPQ
210 220 230 240 250
QKKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCHCES
260 270 280 290 300
MMGFRYRCQQ CHNYQLCQNC FWRGHASGAH SNQHQMKEHS SWKSPAKKLS
310 320 330 340 350
HAISKSLGCV PSREPPHPVF PEQPEKPLDL AHLVPPRPLT NMNDTVVSHM
360 370 380 390 400
SSGVPTPTKR LQYSQDMPNL LADEHALIAS YVARLQHCTR VLDSPSRLDE
410 420 430 440 450
EHRLIARYAA RLAAEAGNMT RPPTDASFNF DANKQQRQLI AELENKNREI
460 470 480 490 500
LQEIQRLRLE HEQASQPTPE KAQQNPMLLA ELRLLRQRKD ELEQRMSALQ
510 520 530 540 550
ESRRELMVQL EGLMKLLKAQ ATGSPHTSPT HGGGRPMPMP VRSTSAGSTP
560 570 580 590 600
THGPQDSLSG VGGDVQEAFA QGTRRNLRND LLVAADSITN TMSSLVKELH
610 620 630 640 650
SGAEAEEQAG TEKTREGLPP RGTFLSVFLL HTWTKLAGCQ THSTSRERSQ

AYGKWGGTA
Length:659
Mass (Da):74,399
Last modified:June 28, 2011 - v3
Checksum:i27AB3141A65797A8
GO
Isoform 2 (identifier: O70585-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-518: K → KEEEQKQA
     603-608: AEAEEQ → EVTPVS
     609-659: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:615
Mass (Da):69,637
Checksum:i58AA5C4DA74227EA
GO

Sequence cautioni

The sequence CAA75752.1 differs from that shown. Reason: Frameshift at position 621.
The sequence CAA75752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4121L → P in CAA75752. (PubMed:9540997)Curated
Sequence conflicti465 – 4651S → F in CAA05796. (PubMed:9419360)Curated
Sequence conflicti465 – 4651S → F in CAA09038. (PubMed:9799833)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei518 – 5181K → KEEEQKQA in isoform 2. 2 PublicationsVSP_004227
Alternative sequencei603 – 6086AEAEEQ → EVTPVS in isoform 2. 2 PublicationsVSP_004228
Alternative sequencei609 – 65951Missing in isoform 2. 2 PublicationsVSP_004229Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15742 mRNA. Translation: CAA75752.1. Sequence problems.
AJ003007 mRNA. Translation: CAA05796.1.
AJ010204
, AJ010205, AJ010206, AJ010207, AJ010208, AJ010209, AJ010210, AJ010211, AJ010212, AJ010213, AJ010214, AJ010215, AJ010216, AJ010217, AJ010218, AJ010219, AJ010220, AJ010221 Genomic DNA. Translation: CAA09038.1.
AC155273 Genomic DNA. No translation available.
CR974568 Genomic DNA. No translation available.
AK019068 mRNA. No translation available.
CCDSiCCDS49015.1. [O70585-1]
RefSeqiNP_001155937.1. NM_001162465.1. [O70585-1]
UniGeneiMm.286202.

Genome annotation databases

EnsembliENSMUST00000101637; ENSMUSP00000099161; ENSMUSG00000071454. [O70585-2]
ENSMUST00000164578; ENSMUSP00000126194; ENSMUSG00000071454. [O70585-1]
GeneIDi13528.
KEGGimmu:13528.
UCSCiuc007mww.2. mouse. [O70585-2]
uc007mwy.2. mouse. [O70585-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y15742 mRNA. Translation: CAA75752.1 . Sequence problems.
AJ003007 mRNA. Translation: CAA05796.1 .
AJ010204
, AJ010205 , AJ010206 , AJ010207 , AJ010208 , AJ010209 , AJ010210 , AJ010211 , AJ010212 , AJ010213 , AJ010214 , AJ010215 , AJ010216 , AJ010217 , AJ010218 , AJ010219 , AJ010220 , AJ010221 Genomic DNA. Translation: CAA09038.1 .
AC155273 Genomic DNA. No translation available.
CR974568 Genomic DNA. No translation available.
AK019068 mRNA. No translation available.
CCDSi CCDS49015.1. [O70585-1 ]
RefSeqi NP_001155937.1. NM_001162465.1. [O70585-1 ]
UniGenei Mm.286202.

3D structure databases

ProteinModelPortali O70585.
SMRi O70585. Positions 26-235, 237-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O70585. 7 interactions.
MINTi MINT-197260.

PTM databases

PhosphoSitei O70585.

Proteomic databases

MaxQBi O70585.
PaxDbi O70585.
PRIDEi O70585.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000101637 ; ENSMUSP00000099161 ; ENSMUSG00000071454 . [O70585-2 ]
ENSMUST00000164578 ; ENSMUSP00000126194 ; ENSMUSG00000071454 . [O70585-1 ]
GeneIDi 13528.
KEGGi mmu:13528.
UCSCi uc007mww.2. mouse. [O70585-2 ]
uc007mwy.2. mouse. [O70585-1 ]

Organism-specific databases

CTDi 1838.
MGIi MGI:1203728. Dtnb.

Phylogenomic databases

eggNOGi NOG251970.
GeneTreei ENSGT00760000119237.
HOGENOMi HOG000230684.
HOVERGENi HBG005539.
InParanoidi O70585.
OMAi LEEENSM.
TreeFami TF343849.

Miscellaneous databases

NextBioi 284118.
PROi O70585.
SOURCEi Search...

Gene expression databases

Bgeei O70585.
CleanExi MM_DTNB.
ExpressionAtlasi O70585. baseline and differential.
Genevestigatori O70585.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR017432. Distrobrevin.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view ]
PIRSFi PIRSF038204. Distrobrevin. 1 hit.
SMARTi SM00291. ZnF_ZZ. 1 hit.
[Graphical view ]
PROSITEi PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a novel member of the dystrobrevin gene family."
    Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B.
    FEBS Lett. 425:7-13(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Beta-dystrobrevin, a member of the dystrophin-related protein family."
    Blake D.J., Nawrotzki R., Loh N.Y., Gorecki D.C., Davies K.E.
    Proc. Natl. Acad. Sci. U.S.A. 95:241-246(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Genomic organization and refined mapping of the mouse beta-dystrobrevin gene."
    Loh N.Y., Ambrose H.J., Guay-Woodford L.M., Dasgupta S., Nawrotzki R.A., Blake D.J., Davies K.E.
    Mamm. Genome 9:857-862(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 590-608 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Stomach.
  6. "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain."
    Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., Blake D.J.
    J. Biol. Chem. 276:24232-24241(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYSTROBREVIN BINDING PROTEIN 1.

Entry informationi

Entry nameiDTNB_MOUSE
AccessioniPrimary (citable) accession number: O70585
Secondary accession number(s): E9Q0F2, O70563, Q9CTZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3