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O70585

- DTNB_MOUSE

UniProt

O70585 - DTNB_MOUSE

Protein

Dystrobrevin beta

Gene

Dtnb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dystrobrevin beta
    Short name:
    DTN-B
    Short name:
    mDTN-B
    Alternative name(s):
    Beta-dystrobrevin
    Gene namesi
    Name:Dtnb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1203728. Dtnb.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. synapse Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 659659Dystrobrevin betaPRO_0000086879Add
    BLAST

    Proteomic databases

    PaxDbiO70585.
    PRIDEiO70585.

    PTM databases

    PhosphoSiteiO70585.

    Expressioni

    Tissue specificityi

    Expressed mainly in brain, kidney, liver and lung. In brain expressed in neurons of the cortex and hippocampus.

    Gene expression databases

    ArrayExpressiO70585.
    BgeeiO70585.
    CleanExiMM_DTNB.
    GenevestigatoriO70585.

    Interactioni

    Subunit structurei

    Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 By similarity. Binds dystrobrevin binding protein 1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kif5aP331754EBI-349714,EBI-349710

    Protein-protein interaction databases

    IntActiO70585. 7 interactions.
    MINTiMINT-197260.

    Structurei

    3D structure databases

    ProteinModelPortaliO70585.
    SMRiO70585. Positions 26-235, 237-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni369 – 41850Syntrophin-binding regionAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili429 – 51991Sequence AnalysisAdd
    BLAST

    Domaini

    The coiled coil domain may mediate the interaction with dystrophin.

    Sequence similaritiesi

    Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri237 – 28448ZZ-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG251970.
    GeneTreeiENSGT00740000115370.
    HOGENOMiHOG000230684.
    HOVERGENiHBG005539.
    InParanoidiO70585.
    OMAiLEEENSM.
    TreeFamiTF343849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR017432. Distrobrevin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038204. Distrobrevin. 1 hit.
    SMARTiSM00291. ZnF_ZZ. 1 hit.
    [Graphical view]
    PROSITEiPS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: O70585-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIEEGGNKRK TMAEKRQLFI EMRAQNFDVI RLSTYRTACK LRFVQKRCNL    50
    HLVDIWNMIE AFRDNGLNTL DHSTEISVSR LETVISSIYY QLNKRLPSTH 100
    QISVEQSISL LLNFMVAAYD SEGRGKLTVF SVKAMLATMC GGKMLDKLRY 150
    IFSQMSDSNG LMMFGKLDQF LKEALKLPTA VFEGPSFGYT EHAVRTCFPQ 200
    QKKIMLNMFL DTMMADPPPQ CLVWLPLMHR LAHVENVFHP VECSYCHCES 250
    MMGFRYRCQQ CHNYQLCQNC FWRGHASGAH SNQHQMKEHS SWKSPAKKLS 300
    HAISKSLGCV PSREPPHPVF PEQPEKPLDL AHLVPPRPLT NMNDTVVSHM 350
    SSGVPTPTKR LQYSQDMPNL LADEHALIAS YVARLQHCTR VLDSPSRLDE 400
    EHRLIARYAA RLAAEAGNMT RPPTDASFNF DANKQQRQLI AELENKNREI 450
    LQEIQRLRLE HEQASQPTPE KAQQNPMLLA ELRLLRQRKD ELEQRMSALQ 500
    ESRRELMVQL EGLMKLLKAQ ATGSPHTSPT HGGGRPMPMP VRSTSAGSTP 550
    THGPQDSLSG VGGDVQEAFA QGTRRNLRND LLVAADSITN TMSSLVKELH 600
    SGAEAEEQAG TEKTREGLPP RGTFLSVFLL HTWTKLAGCQ THSTSRERSQ 650
    AYGKWGGTA 659
    Length:659
    Mass (Da):74,399
    Last modified:June 28, 2011 - v3
    Checksum:i27AB3141A65797A8
    GO
    Isoform 2 (identifier: O70585-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         518-518: K → KEEEQKQA
         603-608: AEAEEQ → EVTPVS
         609-659: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:615
    Mass (Da):69,637
    Checksum:i58AA5C4DA74227EA
    GO

    Sequence cautioni

    The sequence CAA75752.1 differs from that shown. Reason: Frameshift at position 621.
    The sequence CAA75752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4121L → P in CAA75752. (PubMed:9540997)Curated
    Sequence conflicti465 – 4651S → F in CAA05796. (PubMed:9419360)Curated
    Sequence conflicti465 – 4651S → F in CAA09038. (PubMed:9799833)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei518 – 5181K → KEEEQKQA in isoform 2. 2 PublicationsVSP_004227
    Alternative sequencei603 – 6086AEAEEQ → EVTPVS in isoform 2. 2 PublicationsVSP_004228
    Alternative sequencei609 – 65951Missing in isoform 2. 2 PublicationsVSP_004229Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15742 mRNA. Translation: CAA75752.1. Sequence problems.
    AJ003007 mRNA. Translation: CAA05796.1.
    AJ010204
    , AJ010205, AJ010206, AJ010207, AJ010208, AJ010209, AJ010210, AJ010211, AJ010212, AJ010213, AJ010214, AJ010215, AJ010216, AJ010217, AJ010218, AJ010219, AJ010220, AJ010221 Genomic DNA. Translation: CAA09038.1.
    AC155273 Genomic DNA. No translation available.
    CR974568 Genomic DNA. No translation available.
    AK019068 mRNA. No translation available.
    CCDSiCCDS49015.1. [O70585-1]
    RefSeqiNP_001155937.1. NM_001162465.1. [O70585-1]
    UniGeneiMm.286202.

    Genome annotation databases

    EnsembliENSMUST00000101637; ENSMUSP00000099161; ENSMUSG00000071454. [O70585-2]
    ENSMUST00000164578; ENSMUSP00000126194; ENSMUSG00000071454. [O70585-1]
    GeneIDi13528.
    KEGGimmu:13528.
    UCSCiuc007mww.2. mouse. [O70585-2]
    uc007mwy.2. mouse. [O70585-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15742 mRNA. Translation: CAA75752.1 . Sequence problems.
    AJ003007 mRNA. Translation: CAA05796.1 .
    AJ010204
    , AJ010205 , AJ010206 , AJ010207 , AJ010208 , AJ010209 , AJ010210 , AJ010211 , AJ010212 , AJ010213 , AJ010214 , AJ010215 , AJ010216 , AJ010217 , AJ010218 , AJ010219 , AJ010220 , AJ010221 Genomic DNA. Translation: CAA09038.1 .
    AC155273 Genomic DNA. No translation available.
    CR974568 Genomic DNA. No translation available.
    AK019068 mRNA. No translation available.
    CCDSi CCDS49015.1. [O70585-1 ]
    RefSeqi NP_001155937.1. NM_001162465.1. [O70585-1 ]
    UniGenei Mm.286202.

    3D structure databases

    ProteinModelPortali O70585.
    SMRi O70585. Positions 26-235, 237-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O70585. 7 interactions.
    MINTi MINT-197260.

    PTM databases

    PhosphoSitei O70585.

    Proteomic databases

    PaxDbi O70585.
    PRIDEi O70585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000101637 ; ENSMUSP00000099161 ; ENSMUSG00000071454 . [O70585-2 ]
    ENSMUST00000164578 ; ENSMUSP00000126194 ; ENSMUSG00000071454 . [O70585-1 ]
    GeneIDi 13528.
    KEGGi mmu:13528.
    UCSCi uc007mww.2. mouse. [O70585-2 ]
    uc007mwy.2. mouse. [O70585-1 ]

    Organism-specific databases

    CTDi 1838.
    MGIi MGI:1203728. Dtnb.

    Phylogenomic databases

    eggNOGi NOG251970.
    GeneTreei ENSGT00740000115370.
    HOGENOMi HOG000230684.
    HOVERGENi HBG005539.
    InParanoidi O70585.
    OMAi LEEENSM.
    TreeFami TF343849.

    Miscellaneous databases

    NextBioi 284118.
    PROi O70585.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O70585.
    Bgeei O70585.
    CleanExi MM_DTNB.
    Genevestigatori O70585.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR017432. Distrobrevin.
    IPR011992. EF-hand-dom_pair.
    IPR015153. EF-hand_dom_typ1.
    IPR015154. EF-hand_dom_typ2.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF09068. EF-hand_2. 1 hit.
    PF09069. EF-hand_3. 1 hit.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038204. Distrobrevin. 1 hit.
    SMARTi SM00291. ZnF_ZZ. 1 hit.
    [Graphical view ]
    PROSITEi PS01357. ZF_ZZ_1. 1 hit.
    PS50135. ZF_ZZ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a novel member of the dystrobrevin gene family."
      Puca A.A., Piluso V.N.G., Belsito A., Sampaolo S., Quaderi N., Rossi E., Di Iorio G., Ballabio A., Franco B.
      FEBS Lett. 425:7-13(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Beta-dystrobrevin, a member of the dystrophin-related protein family."
      Blake D.J., Nawrotzki R., Loh N.Y., Gorecki D.C., Davies K.E.
      Proc. Natl. Acad. Sci. U.S.A. 95:241-246(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Genomic organization and refined mapping of the mouse beta-dystrobrevin gene."
      Loh N.Y., Ambrose H.J., Guay-Woodford L.M., Dasgupta S., Nawrotzki R.A., Blake D.J., Davies K.E.
      Mamm. Genome 9:857-862(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 590-608 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Stomach.
    6. "Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain."
      Benson M.A., Newey S.E., Martin-Rendon E., Hawkes R., Blake D.J.
      J. Biol. Chem. 276:24232-24241(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYSTROBREVIN BINDING PROTEIN 1.

    Entry informationi

    Entry nameiDTNB_MOUSE
    AccessioniPrimary (citable) accession number: O70585
    Secondary accession number(s): E9Q0F2, O70563, Q9CTZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3