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Protein

Homeobox protein Nkx-2.8

Gene

Nkx2-8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible role in the specification of a distinct subset of neurons.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi81 – 14060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • lung development Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • respiratory tube development Source: MGI
  • transcription, DNA-templated Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.8
Alternative name(s):
Homeobox protein NK-2 homolog H
Homeobox protein Nkx-2.9
Gene namesi
Name:Nkx2-8
Synonyms:Nkx-2.9, Nkx2-9, Nkx2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1270158. Nkx2-9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Homeobox protein Nkx-2.8PRO_0000048944Add
BLAST

Proteomic databases

PaxDbiO70584.
PRIDEiO70584.

Expressioni

Tissue specificityi

Prominent expression in ventral brain and neural tube structures.

Gene expression databases

GenevisibleiO70584. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072425.

Structurei

3D structure databases

ProteinModelPortaliO70584.
SMRiO70584. Positions 80-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00840000129671.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiO70584.
KOiK09347.
OMAiQDAQHLP.
OrthoDBiEOG769ZK0.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70584-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSGRLGFT VRSLLNLPEQ DAKPRVRREQ QTCVPQTAAW LESECSHYLS
60 70 80 90 100
SDESGLETSP ADSSQLASLR RESPGSDPEK RRKRRVLFSK AQTLELERRF
110 120 130 140 150
RQQRYLSAPE REQLARLLRL TPTQVKIWFQ NHRYKLKRGR APGITEPSDM
160 170 180 190 200
AASSDLHAAP GLLRRVVVPV LVHDRPPSNN GRGEGTSAVP QDKCSARLAT
210 220 230
ACPVPGYTAF GPGSALGLFP AYQHLAPPAL VSWNW
Length:235
Mass (Da):26,133
Last modified:October 16, 2013 - v2
Checksum:i71ED9B0EA0F204C1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671V → M in CAA75751 (PubMed:9545546).Curated
Sequence conflicti192 – 1921D → E in CAA75751 (PubMed:9545546).Curated
Sequence conflicti207 – 2071Y → N in CAA75751 (PubMed:9545546).Curated
Sequence conflicti212 – 2121P → T in CAA75751 (PubMed:9545546).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15741 mRNA. Translation: CAA75751.1.
AC160393 Genomic DNA. No translation available.
CH466526 Genomic DNA. Translation: EDL36709.1.
BC150762 mRNA. Translation: AAI50763.1.
CCDSiCCDS25923.1.
RefSeqiNP_032727.2. NM_008701.2.
XP_006515596.1. XM_006515533.2.
XP_011242312.1. XM_011244010.1.
UniGeneiMm.129420.

Genome annotation databases

EnsembliENSMUST00000072631; ENSMUSP00000072425; ENSMUSG00000058669.
GeneIDi18094.
KEGGimmu:18094.
UCSCiuc007nph.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15741 mRNA. Translation: CAA75751.1.
AC160393 Genomic DNA. No translation available.
CH466526 Genomic DNA. Translation: EDL36709.1.
BC150762 mRNA. Translation: AAI50763.1.
CCDSiCCDS25923.1.
RefSeqiNP_032727.2. NM_008701.2.
XP_006515596.1. XM_006515533.2.
XP_011242312.1. XM_011244010.1.
UniGeneiMm.129420.

3D structure databases

ProteinModelPortaliO70584.
SMRiO70584. Positions 80-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072425.

Proteomic databases

PaxDbiO70584.
PRIDEiO70584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072631; ENSMUSP00000072425; ENSMUSG00000058669.
GeneIDi18094.
KEGGimmu:18094.
UCSCiuc007nph.1. mouse.

Organism-specific databases

CTDi18094.
MGIiMGI:1270158. Nkx2-9.

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00840000129671.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiO70584.
KOiK09347.
OMAiQDAQHLP.
OrthoDBiEOG769ZK0.
TreeFamiTF351204.

Miscellaneous databases

PROiO70584.
SOURCEiSearch...

Gene expression databases

GenevisibleiO70584. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS."
    Pabst O., Herbrand H., Arnold H.H.
    Mech. Dev. 73:85-93(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNKX28_MOUSE
AccessioniPrimary (citable) accession number: O70584
Secondary accession number(s): B2RWY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 16, 2013
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.