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O70579

- PM34_MOUSE

UniProt

O70579 - PM34_MOUSE

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Protein

Peroxisomal membrane protein PMP34

Gene

Slc25a17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro (By similarity).By similarity

GO - Molecular functioni

  1. ADP transmembrane transporter activity Source: UniProtKB
  2. AMP transmembrane transporter activity Source: UniProtKB
  3. ATP transmembrane transporter activity Source: Ensembl
  4. coenzyme A transmembrane transporter activity Source: UniProtKB
  5. FAD transmembrane transporter activity Source: UniProtKB
  6. FMN transmembrane transporter activity Source: UniProtKB
  7. NAD transporter activity Source: UniProtKB

GO - Biological processi

  1. ADP transport Source: UniProtKB
  2. AMP transport Source: UniProtKB
  3. coenzyme A transmembrane transport Source: UniProtKB
  4. FAD transmembrane transport Source: UniProtKB
  5. fatty acid beta-oxidation Source: Ensembl
  6. fatty acid transport Source: Ensembl
  7. NAD transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_260555. Alpha-oxidation of phytanate.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP34
Alternative name(s):
34 kDa peroxisomal membrane protein
Solute carrier family 25 member 17
Gene namesi
Name:Slc25a17
Synonyms:Pmp34, Pmp35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1342248. Slc25a17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicBy similarity
Transmembranei10 – 3021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini31 – 6636LumenalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini88 – 10417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei105 – 12521Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini126 – 16035LumenalSequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini182 – 20221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 28057LumenalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini302 – 3076CytoplasmicBy similarity

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: UniProtKB
  2. mitochondrion Source: MGI
  3. peroxisomal membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Peroxisomal membrane protein PMP34PRO_0000090706Add
BLAST

Proteomic databases

MaxQBiO70579.
PaxDbiO70579.
PRIDEiO70579.

PTM databases

PhosphoSiteiO70579.

Expressioni

Tissue specificityi

Expressed in liver.

Gene expression databases

BgeeiO70579.
GenevestigatoriO70579.

Interactioni

Subunit structurei

Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023040.

Structurei

3D structure databases

ProteinModelPortaliO70579.
SMRiO70579. Positions 13-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati7 – 9286Solcar 1Add
BLAST
Repeati99 – 19294Solcar 2Add
BLAST
Repeati200 – 29495Solcar 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 147147Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd
BLAST
Regioni244 – 30764Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi190 – 19910Peroxisome localization signalBy similarity

Domaini

The N- and C-terminal portions are exposed to the cytoplasm. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity (By similarity). Lacks a typical peroxisomal sorting signal.By similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258628.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000159426.
HOVERGENiHBG003235.
InParanoidiO70579.
KOiK13354.
OMAiKNEGPQA.
OrthoDBiEOG7Q8CNK.
PhylomeDBiO70579.
TreeFamiTF324772.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHA
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK AVWVKGQRSS
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IIPTNYKGII
160 170 180 190 200
DAFHQIIRDE GILALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA IAKAIATTVT YPMQTVQSIL RFGRHRLNPE NRTLGSLRNV
260 270 280 290 300
LSLLHQRVKR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG

LKSTHKH
Length:307
Mass (Da):34,413
Last modified:August 1, 1998 - v1
Checksum:i8CE406CE66D0EB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006341 mRNA. Translation: CAA06984.1.
AK002388 mRNA. Translation: BAB22062.1.
BC008571 mRNA. Translation: AAH08571.1.
BC011292 mRNA. Translation: AAH11292.1.
CCDSiCCDS27666.1.
RefSeqiNP_035529.1. NM_011399.3.
UniGeneiMm.222536.

Genome annotation databases

EnsembliENSMUST00000023040; ENSMUSP00000023040; ENSMUSG00000022404.
GeneIDi20524.
KEGGimmu:20524.
UCSCiuc007wwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006341 mRNA. Translation: CAA06984.1 .
AK002388 mRNA. Translation: BAB22062.1 .
BC008571 mRNA. Translation: AAH08571.1 .
BC011292 mRNA. Translation: AAH11292.1 .
CCDSi CCDS27666.1.
RefSeqi NP_035529.1. NM_011399.3.
UniGenei Mm.222536.

3D structure databases

ProteinModelPortali O70579.
SMRi O70579. Positions 13-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000023040.

PTM databases

PhosphoSitei O70579.

Proteomic databases

MaxQBi O70579.
PaxDbi O70579.
PRIDEi O70579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023040 ; ENSMUSP00000023040 ; ENSMUSG00000022404 .
GeneIDi 20524.
KEGGi mmu:20524.
UCSCi uc007wwk.1. mouse.

Organism-specific databases

CTDi 10478.
MGIi MGI:1342248. Slc25a17.

Phylogenomic databases

eggNOGi NOG258628.
GeneTreei ENSGT00770000120566.
HOGENOMi HOG000159426.
HOVERGENi HBG003235.
InParanoidi O70579.
KOi K13354.
OMAi KNEGPQA.
OrthoDBi EOG7Q8CNK.
PhylomeDBi O70579.
TreeFami TF324772.

Enzyme and pathway databases

Reactomei REACT_260555. Alpha-oxidation of phytanate.

Miscellaneous databases

NextBioi 298759.
PROi O70579.
SOURCEi Search...

Gene expression databases

Bgeei O70579.
Genevestigatori O70579.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii."
    Wylin T., Baes M., Brees C., Mannaerts G.P., Fransen M., Van Veldhoven P.P.
    Eur. J. Biochem. 258:332-338(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPM34_MOUSE
AccessioniPrimary (citable) accession number: O70579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3