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Protein

Peroxisomal membrane protein PMP34

Gene

Slc25a17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD+), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD+ from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'-phosphate and bathophenanthroline in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-389599. Alpha-oxidation of phytanate.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP34
Alternative name(s):
34 kDa peroxisomal membrane protein
Solute carrier family 25 member 17
Gene namesi
Name:Slc25a17
Synonyms:Pmp34, Pmp35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1342248. Slc25a17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicBy similarity9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 66LumenalSequence analysisAdd BLAST36
Transmembranei67 – 87Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini88 – 104CytoplasmicSequence analysisAdd BLAST17
Transmembranei105 – 125Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini126 – 160LumenalSequence analysisAdd BLAST35
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 202CytoplasmicSequence analysisAdd BLAST21
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 280LumenalSequence analysisAdd BLAST57
Transmembranei281 – 301Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini302 – 307CytoplasmicBy similarity6

GO - Cellular componenti

  • integral component of peroxisomal membrane Source: UniProtKB
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • mitochondrion Source: MGI
  • peroxisomal membrane Source: MGI
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907061 – 307Peroxisomal membrane protein PMP34Add BLAST307

Proteomic databases

EPDiO70579.
MaxQBiO70579.
PaxDbiO70579.
PeptideAtlasiO70579.
PRIDEiO70579.

PTM databases

PhosphoSitePlusiO70579.

Expressioni

Tissue specificityi

Expressed in liver.

Gene expression databases

BgeeiENSMUSG00000022404.
GenevisibleiO70579. MM.

Interactioni

Subunit structurei

Interacts (via N- and C-terminus peroxisomal targeting regions) with PEX19; the interaction occurs with the newly synthesized SLC25A17 in the cytosol.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023040.

Structurei

3D structure databases

ProteinModelPortaliO70579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 92Solcar 1Add BLAST86
Repeati99 – 192Solcar 2Add BLAST94
Repeati200 – 294Solcar 3Add BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 147Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd BLAST147
Regioni244 – 307Necessary for targeting to peroxisomes and interaction with PEX19By similarityAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi190 – 199Peroxisome localization signalBy similarity10

Domaini

The N- and C-terminal portions are exposed to the cytoplasm. A region between helical transmembrane domains (TM) 4 and 5 and TM1-TM3 or TM4-TM6 are necessary for the peroxisome-targeting activity (By similarity). Lacks a typical peroxisomal sorting signal.By similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0769. Eukaryota.
ENOG410ZNC0. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000159426.
HOVERGENiHBG003235.
InParanoidiO70579.
KOiK13354.
OMAiMGLKSAH.
OrthoDBiEOG091G0DMQ.
PhylomeDBiO70579.
TreeFamiTF324772.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O70579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLSYESL VHAVAGAVGS VTAMTVFFPL DTARLRLQVD EKRKSKTTHA
60 70 80 90 100
VLLEIIKEEG LLAPYRGWFP VISSLCCSNF VYFYTFNSLK AVWVKGQRSS
110 120 130 140 150
TGKDLVVGFV AGVVNVLLTT PLWVVNTRLK LQGAKFRNED IIPTNYKGII
160 170 180 190 200
DAFHQIIRDE GILALWNGTF PSLLLVFNPA IQFMFYEGLK RQLLKKRMKL
210 220 230 240 250
SSLDVFIIGA IAKAIATTVT YPMQTVQSIL RFGRHRLNPE NRTLGSLRNV
260 270 280 290 300
LSLLHQRVKR FGIMGLYKGL EAKLLQTVLT AALMFLVYEK LTAATFTVMG

LKSTHKH
Length:307
Mass (Da):34,413
Last modified:August 1, 1998 - v1
Checksum:i8CE406CE66D0EB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006341 mRNA. Translation: CAA06984.1.
AK002388 mRNA. Translation: BAB22062.1.
BC008571 mRNA. Translation: AAH08571.1.
BC011292 mRNA. Translation: AAH11292.1.
CCDSiCCDS27666.1.
RefSeqiNP_035529.1. NM_011399.3.
UniGeneiMm.222536.

Genome annotation databases

EnsembliENSMUST00000023040; ENSMUSP00000023040; ENSMUSG00000022404.
GeneIDi20524.
KEGGimmu:20524.
UCSCiuc007wwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006341 mRNA. Translation: CAA06984.1.
AK002388 mRNA. Translation: BAB22062.1.
BC008571 mRNA. Translation: AAH08571.1.
BC011292 mRNA. Translation: AAH11292.1.
CCDSiCCDS27666.1.
RefSeqiNP_035529.1. NM_011399.3.
UniGeneiMm.222536.

3D structure databases

ProteinModelPortaliO70579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023040.

PTM databases

PhosphoSitePlusiO70579.

Proteomic databases

EPDiO70579.
MaxQBiO70579.
PaxDbiO70579.
PeptideAtlasiO70579.
PRIDEiO70579.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023040; ENSMUSP00000023040; ENSMUSG00000022404.
GeneIDi20524.
KEGGimmu:20524.
UCSCiuc007wwk.1. mouse.

Organism-specific databases

CTDi10478.
MGIiMGI:1342248. Slc25a17.

Phylogenomic databases

eggNOGiKOG0769. Eukaryota.
ENOG410ZNC0. LUCA.
GeneTreeiENSGT00770000120566.
HOGENOMiHOG000159426.
HOVERGENiHBG003235.
InParanoidiO70579.
KOiK13354.
OMAiMGLKSAH.
OrthoDBiEOG091G0DMQ.
PhylomeDBiO70579.
TreeFamiTF324772.

Enzyme and pathway databases

ReactomeiR-MMU-389599. Alpha-oxidation of phytanate.

Miscellaneous databases

PROiO70579.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022404.
GenevisibleiO70579. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPM34_MOUSE
AccessioniPrimary (citable) accession number: O70579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.