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O70578 (CCG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene names
Name:Cacng1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

Subunit structure

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Voltage-dependent calcium channel gamma-1 subunit
PRO_0000164670

Regions

Transmembrane11 – 2919Helical; Potential
Transmembrane106 – 13025Helical; Potential
Transmembrane141 – 15616Helical; Potential
Transmembrane181 – 20525Helical; Potential

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation801N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O70578 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 3712F856CAFAE5F9

FASTA22325,120
        10         20         30         40         50         60 
MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH FGLWRICTAR 

        70         80         90        100        110        120 
VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT QKEYSISAAA IAIFSLGFII 

       130        140        150        160        170        180 
VGSICAFLSF GNKRDYLLRP ASMFYAFAGL CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS 

       190        200        210        220 
WSFACACAAF ILLFLGGLFL LLFSLPRMPQ NPWESCMDAE PEH 

« Hide

References

[1]"The structure of the murine calcium channel gamma-subunit gene and protein."
Wissenbach U., Bosse-Doenecke E., Freise D., Ludwig A., Murakami M., Hofmann F., Flockerzi V.
Biol. Chem. 379:45-50(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
Tissue: Skeletal muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006306 mRNA. Translation: CAA06966.1.
CCDSCCDS25570.1.
RefSeqNP_031608.1. NM_007582.2.
UniGeneMm.57093.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO70578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
GeneID12299.
KEGGmmu:12299.
UCSCuc007may.1. mouse.

Organism-specific databases

CTD786.
MGIMGI:1206582. Cacng1.

Phylogenomic databases

eggNOGNOG47450.
HOGENOMHOG000293219.
HOVERGENHBG003868.
InParanoidO70578.
KOK04866.
OMAWAVLSPH.
OrthoDBEOG7WQ7TF.
PhylomeDBO70578.
TreeFamTF331651.

Gene expression databases

BgeeO70578.
GenevestigatorO70578.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetSearch...

Other

NextBio280818.
PROO70578.
SOURCESearch...

Entry information

Entry nameCCG1_MOUSE
AccessionPrimary (citable) accession number: O70578
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot