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O70578

- CCG1_MOUSE

UniProt

O70578 - CCG1_MOUSE

Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

    GO - Molecular functioni

    1. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. calcium ion transmembrane transport Source: MGI
    2. sarcoplasmic reticulum calcium ion transport Source: MGI

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent calcium channel gamma-1 subunit
    Alternative name(s):
    Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
    Gene namesi
    Name:Cacng1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1206582. Cacng1.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Voltage-dependent calcium channel gamma-1 subunitPRO_0000164670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO70578.

    Expressioni

    Gene expression databases

    BgeeiO70578.
    GenevestigatoriO70578.

    Interactioni

    Subunit structurei

    The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 2919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei106 – 13025HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 15616HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20525HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47450.
    HOGENOMiHOG000293219.
    HOVERGENiHBG003868.
    InParanoidiO70578.
    KOiK04866.
    OMAiWAVLSPH.
    OrthoDBiEOG7WQ7TF.
    PhylomeDBiO70578.
    TreeFamiTF331651.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    IPR005421. VDCC_g1su.
    IPR008368. VDCC_gsu.
    [Graphical view]
    PfamiPF13903. Claudin_2. 1 hit.
    [Graphical view]
    PRINTSiPR01792. VDCCGAMMA.
    PR01601. VDCCGAMMA1.

    Sequencei

    Sequence statusi: Complete.

    O70578-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH    50
    FGLWRICTAR VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT 100
    QKEYSISAAA IAIFSLGFII VGSICAFLSF GNKRDYLLRP ASMFYAFAGL 150
    CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS WSFACACAAF ILLFLGGLFL 200
    LLFSLPRMPQ NPWESCMDAE PEH 223
    Length:223
    Mass (Da):25,120
    Last modified:August 1, 1998 - v1
    Checksum:i3712F856CAFAE5F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006306 mRNA. Translation: CAA06966.1.
    CCDSiCCDS25570.1.
    RefSeqiNP_031608.1. NM_007582.2.
    UniGeneiMm.57093.

    Genome annotation databases

    EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
    GeneIDi12299.
    KEGGimmu:12299.
    UCSCiuc007may.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006306 mRNA. Translation: CAA06966.1 .
    CCDSi CCDS25570.1.
    RefSeqi NP_031608.1. NM_007582.2.
    UniGenei Mm.57093.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O70578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021065 ; ENSMUSP00000021065 ; ENSMUSG00000020722 .
    GeneIDi 12299.
    KEGGi mmu:12299.
    UCSCi uc007may.1. mouse.

    Organism-specific databases

    CTDi 786.
    MGIi MGI:1206582. Cacng1.

    Phylogenomic databases

    eggNOGi NOG47450.
    HOGENOMi HOG000293219.
    HOVERGENi HBG003868.
    InParanoidi O70578.
    KOi K04866.
    OMAi WAVLSPH.
    OrthoDBi EOG7WQ7TF.
    PhylomeDBi O70578.
    TreeFami TF331651.

    Miscellaneous databases

    NextBioi 280818.
    PROi O70578.
    SOURCEi Search...

    Gene expression databases

    Bgeei O70578.
    Genevestigatori O70578.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    IPR005421. VDCC_g1su.
    IPR008368. VDCC_gsu.
    [Graphical view ]
    Pfami PF13903. Claudin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01792. VDCCGAMMA.
    PR01601. VDCCGAMMA1.
    ProtoNeti Search...

    Publicationsi

    1. "The structure of the murine calcium channel gamma-subunit gene and protein."
      Wissenbach U., Bosse-Doenecke E., Freise D., Ludwig A., Murakami M., Hofmann F., Flockerzi V.
      Biol. Chem. 379:45-50(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiCCG1_MOUSE
    AccessioniPrimary (citable) accession number: O70578
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3