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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • calcium ion transmembrane transport Source: MGI
  • sarcoplasmic reticulum calcium ion transport Source: MGI

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1206582. Cacng1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 29HelicalSequence analysisAdd BLAST19
Transmembranei106 – 130HelicalSequence analysisAdd BLAST25
Transmembranei141 – 156HelicalSequence analysisAdd BLAST16
Transmembranei181 – 205HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646701 – 223Voltage-dependent calcium channel gamma-1 subunitAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70578.
PRIDEiO70578.

PTM databases

PhosphoSitePlusiO70578.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020722.
ExpressionAtlasiO70578. baseline and differential.
GenevisibleiO70578. MM.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021065.

Structurei

3D structure databases

ProteinModelPortaliO70578.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I. Eukaryota.
ENOG4111J5G. LUCA.
GeneTreeiENSGT00390000007786.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiO70578.
KOiK04866.
OMAiEKNCSYF.
OrthoDBiEOG091G0IU0.
PhylomeDBiO70578.
TreeFamiTF331651.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
PfamiView protein in Pfam
PF13903. Claudin_2. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.

Sequencei

Sequence statusi: Complete.

O70578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH
60 70 80 90 100
FGLWRICTAR VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII VGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS WSFACACAAF ILLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDAE PEH
Length:223
Mass (Da):25,120
Last modified:August 1, 1998 - v1
Checksum:i3712F856CAFAE5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA. Translation: CAA06966.1.
CCDSiCCDS25570.1.
RefSeqiNP_031608.1. NM_007582.2.
UniGeneiMm.57093.

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
GeneIDi12299.
KEGGimmu:12299.
UCSCiuc007may.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCCG1_MOUSE
AccessioniPrimary (citable) accession number: O70578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families