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Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  1. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. calcium ion transmembrane transport Source: MGI
  2. sarcoplasmic reticulum calcium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1206582. Cacng1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 2919HelicalSequence AnalysisAdd
BLAST
Transmembranei106 – 13025HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 15616HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20525HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Voltage-dependent calcium channel gamma-1 subunitPRO_0000164670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO70578.

Expressioni

Gene expression databases

BgeeiO70578.
ExpressionAtlasiO70578. baseline and differential.
GenevestigatoriO70578.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47450.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiO70578.
KOiK04866.
OMAiHNTTCEA.
OrthoDBiEOG7WQ7TF.
PhylomeDBiO70578.
TreeFamiTF331651.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.

Sequencei

Sequence statusi: Complete.

O70578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH
60 70 80 90 100
FGLWRICTAR VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII VGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS WSFACACAAF ILLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDAE PEH
Length:223
Mass (Da):25,120
Last modified:July 31, 1998 - v1
Checksum:i3712F856CAFAE5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA. Translation: CAA06966.1.
CCDSiCCDS25570.1.
RefSeqiNP_031608.1. NM_007582.2.
UniGeneiMm.57093.

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
GeneIDi12299.
KEGGimmu:12299.
UCSCiuc007may.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA. Translation: CAA06966.1.
CCDSiCCDS25570.1.
RefSeqiNP_031608.1. NM_007582.2.
UniGeneiMm.57093.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO70578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
GeneIDi12299.
KEGGimmu:12299.
UCSCiuc007may.1. mouse.

Organism-specific databases

CTDi786.
MGIiMGI:1206582. Cacng1.

Phylogenomic databases

eggNOGiNOG47450.
HOGENOMiHOG000293219.
HOVERGENiHBG003868.
InParanoidiO70578.
KOiK04866.
OMAiHNTTCEA.
OrthoDBiEOG7WQ7TF.
PhylomeDBiO70578.
TreeFamiTF331651.

Miscellaneous databases

NextBioi280818.
PROiO70578.
SOURCEiSearch...

Gene expression databases

BgeeiO70578.
ExpressionAtlasiO70578. baseline and differential.
GenevestigatoriO70578.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
IPR005421. VDCC_g1su.
IPR008368. VDCC_gsu.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
PRINTSiPR01792. VDCCGAMMA.
PR01601. VDCCGAMMA1.
ProtoNetiSearch...

Publicationsi

  1. "The structure of the murine calcium channel gamma-subunit gene and protein."
    Wissenbach U., Bosse-Doenecke E., Freise D., Ludwig A., Murakami M., Hofmann F., Flockerzi V.
    Biol. Chem. 379:45-50(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiCCG1_MOUSE
AccessioniPrimary (citable) accession number: O70578
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2001
Last sequence update: July 31, 1998
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.