O70578 (CCG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent calcium channel gamma-1 subunit

Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma

Gene names

Name:

Cacng1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.
Subunit structure	The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sarcoplasmic reticulum calcium ion transport Inferred from mutant phenotype PubMed 15504904. Source: MGI
Cellular_component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated calcium channel activity Inferred from mutant phenotype PubMed 10799530PubMed 15504904. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 223	223	Voltage-dependent calcium channel gamma-1 subunit		PRO_0000164670
Regions
	Transmembrane	11 – 29	19	Helical; Potential
	Transmembrane	106 – 130	25	Helical; Potential
	Transmembrane	141 – 156	16	Helical; Potential
	Transmembrane	181 – 205	25	Helical; Potential
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O70578 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 3712F856CAFAE5F9	FASTA	223	25,120
	10 20 30 40 50 60 MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH FGLWRICTAR 70 80 90 100 110 120 VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT QKEYSISAAA IAIFSLGFII 130 140 150 160 170 180 VGSICAFLSF GNKRDYLLRP ASMFYAFAGL CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS 190 200 210 220 WSFACACAAF ILLFLGGLFL LLFSLPRMPQ NPWESCMDAE PEH

References

[1]	"The structure of the murine calcium channel gamma-subunit gene and protein." Wissenbach U., Bosse-Doenecke E., Freise D., Ludwig A., Murakami M., Hofmann F., Flockerzi V. Biol. Chem. 379:45-50(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ. Tissue: Skeletal muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ006306 mRNA. Translation: CAA06966.1.
IPI	IPI00119463.
RefSeq	NP_031608.1. NM_007582.2.
UniGene	Mm.57093.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O70578.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722.
GeneID	12299.
KEGG	mmu:12299.
Organism-specific databases
CTD	786.
MGI	MGI:1206582. Cacng1.
Phylogenomic databases
eggNOG	NOG47450.
HOGENOM	HOG000293219.
HOVERGEN	HBG003868.
InParanoid	O70578.
KO	K04866.
OMA	WAVLSPH.
OrthoDB	EOG49PB0K.
Gene expression databases
ArrayExpress	O70578.
Bgee	O70578.
Genevestigator	O70578.
GermOnline	ENSMUSG00000020722. Mus musculus.
Family and domain databases
InterPro	IPR005421. VDCC_g1su. IPR008368. VDCC_gsu. [Graphical view]
PRINTS	PR01792. VDCCGAMMA. PR01601. VDCCGAMMA1.
ProtoNet	Search...
Other
NextBio	280818.
SOURCE	Search...

Entry information

Entry name

CCG1_MOUSE

Accession

Primary (citable) accession number: O70578

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program