Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent calcium channel gamma-1 subunit

Gene

Cacng1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca2+ channel may function only as a multiple subunit complex.

GO - Molecular functioni

  • voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  • calcium ion transmembrane transport Source: MGI
  • regulation of ion transmembrane transport Source: UniProtKB-KW
  • sarcoplasmic reticulum calcium ion transport Source: MGI

Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation
R-MMU-5576893 Phase 2 - plateau phase

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel gamma-1 subunit
Alternative name(s):
Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma
Gene namesi
Name:Cacng1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1206582 Cacng1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 29HelicalSequence analysisAdd BLAST19
Transmembranei106 – 130HelicalSequence analysisAdd BLAST25
Transmembranei141 – 156HelicalSequence analysisAdd BLAST16
Transmembranei181 – 205HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646701 – 223Voltage-dependent calcium channel gamma-1 subunitAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO70578
PRIDEiO70578

PTM databases

PhosphoSitePlusiO70578

Expressioni

Gene expression databases

BgeeiENSMUSG00000020722
ExpressionAtlasiO70578 baseline and differential
GenevisibleiO70578 MM

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.

Protein-protein interaction databases

ComplexPortaliCPX-3191 Skeletal muscle VGCC complex
STRINGi10090.ENSMUSP00000021065

Structurei

3D structure databases

ProteinModelPortaliO70578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0I Eukaryota
ENOG4111J5G LUCA
GeneTreeiENSGT00390000007786
HOGENOMiHOG000293219
HOVERGENiHBG003868
InParanoidiO70578
KOiK04866
OMAiEKNCSYF
OrthoDBiEOG091G0IU0
PhylomeDBiO70578
TreeFamiTF331651

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR005421 VDCC_g1su
IPR008368 VDCC_gsu
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
PRINTSiPR01792 VDCCGAMMA
PR01601 VDCCGAMMA1

Sequencei

Sequence statusi: Complete.

O70578-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTKTAKVR VTLFFILVGG VLAMVAVVTD HWAVLSPHLE HHNETCEAAH
60 70 80 90 100
FGLWRICTAR VAVHNKDKSC EHVTPSGEKN CSYFRHFNPG ESSEIFEFTT
110 120 130 140 150
QKEYSISAAA IAIFSLGFII VGSICAFLSF GNKRDYLLRP ASMFYAFAGL
160 170 180 190 200
CLIVSVEVMR QSVKRMIDSE DTVWIEHYYS WSFACACAAF ILLFLGGLFL
210 220
LLFSLPRMPQ NPWESCMDAE PEH
Length:223
Mass (Da):25,120
Last modified:August 1, 1998 - v1
Checksum:i3712F856CAFAE5F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006306 mRNA Translation: CAA06966.1
CCDSiCCDS25570.1
RefSeqiNP_031608.1, NM_007582.2
UniGeneiMm.57093

Genome annotation databases

EnsembliENSMUST00000021065; ENSMUSP00000021065; ENSMUSG00000020722
GeneIDi12299
KEGGimmu:12299
UCSCiuc007may.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCCG1_MOUSE
AccessioniPrimary (citable) accession number: O70578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: August 1, 1998
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health