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O70577

- S22A2_MOUSE

UniProt

O70577 - S22A2_MOUSE

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Protein

Solute carrier family 22 member 2

Gene
Slc22a2, Oct2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei451 – 4511Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations By similarity

GO - Molecular functioni

  1. choline transmembrane transporter activity Source: Ensembl
  2. organic cation transmembrane transporter activity Source: MGI
  3. quaternary ammonium group transmembrane transporter activity Source: Ensembl
  4. steroid binding Source: Ensembl

GO - Biological processi

  1. cation transport Source: MGI
  2. histamine transport Source: Ensembl
  3. organic cation transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 2
Alternative name(s):
Organic cation transporter 2
Gene namesi
Name:Slc22a2
Synonyms:Oct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1335072. Slc22a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Topological domaini43 – 150108Extracellular Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Topological domaini172 – 1776Cytoplasmic Reviewed prediction
Transmembranei178 – 19821Helical; Reviewed predictionAdd
BLAST
Topological domaini199 – 21012Extracellular Reviewed predictionAdd
BLAST
Transmembranei211 – 23121Helical; Reviewed predictionAdd
BLAST
Topological domaini232 – 2387Cytoplasmic Reviewed prediction
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST
Topological domaini260 – 2634Extracellular Reviewed prediction
Transmembranei264 – 28421Helical; Reviewed predictionAdd
BLAST
Topological domaini285 – 34864Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei349 – 36921Helical; Reviewed predictionAdd
BLAST
Topological domaini370 – 3756Extracellular Reviewed prediction
Transmembranei376 – 39621Helical; Reviewed predictionAdd
BLAST
Topological domaini397 – 4048Cytoplasmic Reviewed prediction
Transmembranei405 – 42521Helical; Reviewed predictionAdd
BLAST
Topological domaini426 – 4327Extracellular Reviewed prediction
Transmembranei433 – 45321Helical; Reviewed predictionAdd
BLAST
Topological domaini454 – 46411Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei465 – 48521Helical; Reviewed predictionAdd
BLAST
Topological domaini486 – 4949Extracellular Reviewed prediction
Transmembranei495 – 51521Helical; Reviewed predictionAdd
BLAST
Topological domaini516 – 55338Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 22 member 2PRO_0000320958Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO70577.
PaxDbiO70577.
PRIDEiO70577.

PTM databases

PhosphoSiteiO70577.

Expressioni

Tissue specificityi

Expressed in kidney and ureter. To a lower extent, also expressed in brain and embryo.1 Publication

Gene expression databases

BgeeiO70577.
GenevestigatoriO70577.

Structurei

3D structure databases

ProteinModelPortaliO70577.
SMRiO70577. Positions 158-519.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00730000110561.
HOGENOMiHOG000234568.
HOVERGENiHBG061545.
InParanoidiO70577.
KOiK08199.
OMAiHMGLAGG.
OrthoDBiEOG78PV8N.
PhylomeDBiO70577.
TreeFamiTF315847.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O70577-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPTVDDILEH IGEFHLFQKQ TFFLLALLSG AFTPIYVGIV FLGFTPNHHC    50
RSPGVAELSQ RCGWSPAEEL NYTVPGLGSA GEVSFLSQCM RYEVDWNQST 100
LDCVDPLSSL AANRSHLPLS PCEHGWVYDT PGSSIVTEFN LVCAHSWMLD 150
LFQSLVNVGF FIGAVGIGYL ADRFGRKFCL LVTILINAIS GVLMAISPNY 200
AWMLVFRFLQ GLVSKAGWLI GYILITEFVG LGYRRTVGIC YQIAFTVGLL 250
ILAGVAYALP NWRWLQFAVT LPNFCFLLYF WCIPESPRWL ISQNKNAKAM 300
KIIKHIAKKN GKSVPVSLQS LTADEDTGMK LNPSFLDLVR TPQIRKHTLI 350
LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFIIILTIDR 400
IGRRYPWAVS NMVAGAACLA SVFIPDDLQW LKITVACLGR MGITIAYEMV 450
CLVNAELYPT YIRNLAVLVC SSMCDIGGIV TPFLVYRLTD IWLEFPLVVF 500
AVVGLVAGGL VLLLPETKGK ALPETIEDAE KMQRPRKKKE KRIYLQVKKA 550
ELS 553
Length:553
Mass (Da):61,831
Last modified:August 1, 1998 - v1
Checksum:i1E9744F0D5415483
GO
Isoform 2 (identifier: O70577-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     534-544: RPRKKKEKRIY → SLGRLVQTVCH
     545-553: Missing.

Note: No experimental confirmation available.

Show »
Length:544
Mass (Da):60,544
Checksum:i3A50BB93491211AE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei534 – 54411RPRKKKEKRIY → SLGRLVQTVCH in isoform 2. VSP_031775Add
BLAST
Alternative sequencei545 – 5539Missing in isoform 2. VSP_031776

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006036 mRNA. Translation: CAA06827.1.
AK052658 mRNA. Translation: BAC35086.1.
BC015250 mRNA. Translation: AAH15250.1.
BC069911 mRNA. Translation: AAH69911.1.
AF481054 Genomic DNA. Translation: AAM22158.1.
CCDSiCCDS28392.1. [O70577-1]
RefSeqiNP_038695.1. NM_013667.2. [O70577-1]
UniGeneiMm.17322.

Genome annotation databases

EnsembliENSMUST00000046959; ENSMUSP00000041186; ENSMUSG00000040966. [O70577-1]
GeneIDi20518.
KEGGimmu:20518.
UCSCiuc008akw.1. mouse. [O70577-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006036 mRNA. Translation: CAA06827.1 .
AK052658 mRNA. Translation: BAC35086.1 .
BC015250 mRNA. Translation: AAH15250.1 .
BC069911 mRNA. Translation: AAH69911.1 .
AF481054 Genomic DNA. Translation: AAM22158.1 .
CCDSi CCDS28392.1. [O70577-1 ]
RefSeqi NP_038695.1. NM_013667.2. [O70577-1 ]
UniGenei Mm.17322.

3D structure databases

ProteinModelPortali O70577.
SMRi O70577. Positions 158-519.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073662.

PTM databases

PhosphoSitei O70577.

Proteomic databases

MaxQBi O70577.
PaxDbi O70577.
PRIDEi O70577.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046959 ; ENSMUSP00000041186 ; ENSMUSG00000040966 . [O70577-1 ]
GeneIDi 20518.
KEGGi mmu:20518.
UCSCi uc008akw.1. mouse. [O70577-1 ]

Organism-specific databases

CTDi 6582.
MGIi MGI:1335072. Slc22a2.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00730000110561.
HOGENOMi HOG000234568.
HOVERGENi HBG061545.
InParanoidi O70577.
KOi K08199.
OMAi HMGLAGG.
OrthoDBi EOG78PV8N.
PhylomeDBi O70577.
TreeFami TF315847.

Enzyme and pathway databases

Reactomei REACT_196555. Abacavir transmembrane transport.
REACT_198610. Organic cation transport.

Miscellaneous databases

NextBioi 298735.
PROi O70577.
SOURCEi Search...

Gene expression databases

Bgeei O70577.
Genevestigatori O70577.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004749. Orgcat_transp.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
TIGRFAMsi TIGR00898. 2A0119. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus."
    Mooslehner K.A., Allen N.D.
    Mamm. Genome 10:218-224(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: 129 and BALB/c.
    Tissue: Kidney and Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.
  4. "Genomic sequence analysis in the mouse T-complex region."
    Brathwaite M., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 226-553.
    Strain: 129S6/SvEvTac.

Entry informationi

Entry nameiS22A2_MOUSE
AccessioniPrimary (citable) accession number: O70577
Secondary accession number(s): Q8BWF6, Q8K4X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi