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Protein

Cohesin subunit SA-3

Gene

Stag3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.2 Publications

GO - Biological processi

  • female meiosis sister chromatid cohesion Source: MGI
  • male meiosis sister chromatid cohesion Source: MGI
  • protein localization to chromosome Source: MGI
  • synapsis Source: MGI

Keywordsi

Biological processCell cycle, Chromosome partition, Meiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cohesin subunit SA-3
Alternative name(s):
SCC3 homolog 3
Stromal antigen 3
Stromalin-3
Gene namesi
Name:Stag3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1355311 Stag3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Deficient mice are sterile and their fetal oocytes are arrested at early prophase I leading to oocyte depletion at 1 week of age.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001201891 – 1240Cohesin subunit SA-3Add BLAST1240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1218PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO70576
PaxDbiO70576
PeptideAtlasiO70576
PRIDEiO70576

PTM databases

iPTMnetiO70576
PhosphoSitePlusiO70576

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSMUSG00000036928
CleanExiMM_STAG3
ExpressionAtlasiO70576 baseline and differential
GenevisibleiO70576 MM

Interactioni

Subunit structurei

Component of the meiosis-specific cohesin complex, which also contains the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer. Such complex likely contains RAD21, or the meiosis-specific related protein REC8 (By similarity). Interacts with CCDC79/TERB1; recruiting cohesin to telomeres to develop structural rigidity.By similarity2 Publications

Protein-protein interaction databases

BioGridi206141, 1 interactor
CORUMiO70576
DIPiDIP-60731N
IntActiO70576, 5 interactors
MINTiO70576
STRINGi10090.ENSMUSP00000040945

Structurei

3D structure databases

SMRiO70576
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini324 – 409SCDPROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1195 – 1201Poly-Glu7

Sequence similaritiesi

Belongs to the SCC3 family.Curated

Phylogenomic databases

eggNOGiKOG2011 Eukaryota
COG5537 LUCA
GeneTreeiENSGT00390000014094
HOGENOMiHOG000231375
HOVERGENiHBG057636
InParanoidiO70576
KOiK13055
OMAiGFPMDNL
OrthoDBiEOG091G0195
TreeFamiTF314604

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR020839 SCD
IPR013721 STAG
PfamiView protein in Pfam
PF08514 STAG, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS51425 SCD, 1 hit

Sequencei

Sequence statusi: Complete.

O70576-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLWSPSTQ HHGSSSGSES SPLQKSVRRA QMALSPCSSS ILPCDDRDSQ
60 70 80 90 100
GTAEWDSPST NEDSDFEDSL RRNVKKRAAK QPPKAVPAAK HRKKQSRIVS
110 120 130 140 150
SGNGKNESVP STNYLFDAVK AARSCMQSLV DEWLDNYKQD ENAGFLELIN
160 170 180 190 200
FFIRACGCKS TVTPEMFKTM SNSEIIQHLT EEFNEDSGDY PLTAPGPSWK
210 220 230 240 250
KFQGSFCEFV KTLVYQCQYS LLYDGFPMDD LISLLIGLSD SQVRAFRHTS
260 270 280 290 300
TLAAMKLMTS LVKVALQLSL HKDNNQRQYE AERNKGPEQR APERLESLLE
310 320 330 340 350
KRKEFQENQE DIEGMMNAIF RGVFVHRYRD ILPEIRAICI EEIGYWMQSY
360 370 380 390 400
STSFLNDSYL KYIGWTLHDK HKEVRLKCVK ALAGLYSNQE LSLRMELFTN
410 420 430 440 450
RFKDRMVSMV MDRECEVAVE AIRLLTLILK NMEGVLTSAD CEKIYSIVYI
460 470 480 490 500
SNRAMASSAG EFVYWKIFHP ECGAKAVSDR ERRRSPQAQK TFIYLLLAFF
510 520 530 540 550
MESEHHNHAA YLVDSLWDCA GSYLKDWESL TNLLLQKDQN LGDMQERMLI
560 570 580 590 600
EILVSSARQA AEGHPPVGRI TGKKSLTAKE RKLQAYDKMK LAEHLIPLLP
610 620 630 640 650
QLLAKFSADA ENVAPLLQLL SYFDLSIYCT QRLEKHLELL LQQLQEVVVK
660 670 680 690 700
HVEPEVLEAA AHALYLLCKP EFTFFSRVDF ARSQLVDFLT DRFQQELDDL
710 720 730 740 750
MQSSFLDEDE VYSLTATLKR LSAFYNAHDL TRWEISEPCS RLLRKAVDTG
760 770 780 790 800
EVPHQVILPA LTLVYFSILW TVTHISESTS HKQLMSLKKR MVAFCELCQS
810 820 830 840 850
CLSDVDPEIQ EQAFVLLSDL LLIFSPQMIV GGRDFLRPLV FFPEATLQSE
860 870 880 890 900
LASFLMDHVF LQPGELGNGQ SQEDHVQIEL LHQRRRLLAG FCKLLLYGVL
910 920 930 940 950
ELDAASDVFK HYNKFYEDYG DIIKETLTRA RQIDRCQCSR ILLLSLKQLY
960 970 980 990 1000
TELIQEQGPQ GLTELPAFIE MRDLARRFAL SFGPQQLHNR DLVVMLHKEG
1010 1020 1030 1040 1050
IKFSLSELPP AGSSHEPPNL AFLELLSEFS PRLFHQDKRL LLSYLEKCLQ
1060 1070 1080 1090 1100
RVSKAPNHPW GPVTTYCHSL HPLEITAEAS PRGPPHSKKR CVEGPCRPQE
1110 1120 1130 1140 1150
EESSSQEESL QLNSGPTTPT LTSTAVKRKQ SLRTVGKKQK GRPGPGPGPG
1160 1170 1180 1190 1200
PELICSQQLL GTQRLKMSSA PCFQIRCDPS GSGLGKQLTR LSLMEEDEEE
1210 1220 1230 1240
ELRLLDEEWQ RGDKMLHSPS SPSEHGLDLL DTTELNMEDF
Length:1,240
Mass (Da):141,167
Last modified:July 27, 2011 - v2
Checksum:iB3856012BFE76C1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti553L → P in CAA06669 (PubMed:10698974).Curated1
Sequence conflicti604A → D in CAA06669 (PubMed:10698974).Curated1
Sequence conflicti1079A → G in CAA06669 (PubMed:10698974).Curated1
Sequence conflicti1090R → K in CAA06669 (PubMed:10698974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005678 mRNA Translation: CAA06669.1
BC139010 mRNA Translation: AAI39011.1
BC139011 mRNA Translation: AAI39012.1
CCDSiCCDS39344.1
PIRiT30834
RefSeqiNP_058660.2, NM_016964.2
XP_006504659.1, XM_006504596.2
XP_011239250.1, XM_011240948.2
UniGeneiMm.285609

Genome annotation databases

EnsembliENSMUST00000048028; ENSMUSP00000040945; ENSMUSG00000036928
ENSMUST00000162245; ENSMUSP00000125523; ENSMUSG00000036928
GeneIDi50878
KEGGimmu:50878
UCSCiuc009afn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSTAG3_MOUSE
AccessioniPrimary (citable) accession number: O70576
Secondary accession number(s): B2RSV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health